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    CPXM2 carboxypeptidase X (M14 family), member 2 [ Homo sapiens ]

    Gene ID: 119587, updated on 11-May-2012
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    Summary

    Official Symbol
    CPXM2provided by HGNC
    Official Full Name
    carboxypeptidase X (M14 family), member 2provided by HGNC
    Primary source
    HGNC:26977
    Locus tag
    UNQ676/PRO1310
    See related
    Ensembl:ENSG00000121898; HPRD:08517; Vega:OTTHUMG00000019206
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPX2; UNQ676
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    Genomic context

    Location :
    10q26.13
    Sequence :
    Chromosome: 10; NC_000010.10 (125505152..125651500, complement)
    See CPXM2 in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S26 pseudogene 39 Neighboring gene G protein-coupled receptor 26 Neighboring gene Y box binding protein 2 pseudogene Neighboring gene carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Grupe A, et al. Am J Hum Genet, 2006 Jan. PMID 16385451.
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    4. Functional proteomics mapping of a human signaling pathway. Colland F, et al. Genome Res, 2004 Jul. PMID 15231748.
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309.

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q8N436 O15198 SMAD9    HPRD  PubMed  
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		  
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular space IDA
    Inferred from Direct Assay
    more info
    		  
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    General protein information

    Preferred Names
    inactive carboxypeptidase-like protein X2
    Names
    inactive carboxypeptidase-like protein X2
    4632435C11Rik
    carboxypeptidase Hlo
    cytosolic carboxypeptidase
    carboxypeptidase-like protein X2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198148.2 → NP_937791.2  inactive carboxypeptidase-like protein X2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC009987, AY358565
      Consensus CDS
      CCDS7637.1
      UniProtKB/Swiss-Prot
      Q8N436
      Related
      ENSP00000241305, OTTHUMP00000020688, ENST00000241305, OTTHUMT00000050853
      Conserved Domains (4) summary
      cd00057
      Location:137 – 292
      Blast Score: 424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      smart00231
      Location:138 – 293
      Blast Score: 355
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd03869
      Location:314 – 639
      Blast Score: 1660
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
      cd11308
      Location:643 – 718
      Blast Score: 343
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      125505152..125651500, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      119120570..119266868, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC009987.17 None
    genomic AC068058.12 (33299..98487) None
    genomic CH471066.2 EAW49279.1
    mRNA AK296365.1 BAG59040.1
    mRNA AK300506.1 BAG62219.1
    mRNA AK304023.1 BAG64938.1
    mRNA AK304814.1 BAG65564.1
    mRNA AL833732.1 CAH56260.1
    mRNA AY358565.1 AAQ88928.1
    mRNA BC027623.1 AAH27623.1
    mRNA BC036789.1 AAH36789.2
    mRNA BC137492.1 AAI37493.1
    mRNA BC146862.1 AAI46863.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q49AT5 GenPept UniProtKB/TrEMBL:Q49AT5
    Q658N0 GenPept UniProtKB/TrEMBL:Q658N0
    Q8N436.3 GenPept UniProtKB/Swiss-Prot:Q8N436
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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