Format

Send to:

Choose Destination

Atp4a ATPase, H+/K+ exchanging, gastric, alpha polypeptide [ Mus musculus (house mouse) ]

Gene ID: 11944, updated on 8-May-2016
Official Symbol
Atp4aprovided by MGI
Official Full Name
ATPase, H+/K+ exchanging, gastric, alpha polypeptideprovided by MGI
Primary source
MGI:MGI:88113
See related
Ensembl:ENSMUSG00000005553 Vega:OTTMUSG00000036851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Orthologs
Location:
7 B1; 7 19.2 cM
Exon count:
22
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (30712209..30725534)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (31497251..31510553)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene Pmis2, sperm specific protein Neighboring gene RIKEN cDNA 2200002J24 gene Neighboring gene transmembrane protein 147 Neighboring gene transmembrane protein 147, opposite strand Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, spermatogenic

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
alpha-D-galactofuranose transporter activity IEA
Inferred from Electronic Annotation
more info
 
hydrogen:potassium-exchanging ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
sodium:potassium-exchanging ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
ATP hydrolysis coupled proton transport IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
pH reduction IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion import IBA
Inferred from Biological aspect of Ancestor
more info
 
potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
proton transport IEA
Inferred from Electronic Annotation
more info
 
regulation of proton transport IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IMP
Inferred from Mutant Phenotype
more info
PubMed 
sodium ion export from cell IBA
Inferred from Biological aspect of Ancestor
more info
 
sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
potassium-transporting ATPase alpha chain 1
Names
ATPase, H+/K+ exchanging, alpha polypeptide
ATPase, H+/K+ transporting, alpha polypeptide
H+/K+-ATPase alpha
H+K+-transporting alpha 1
gastric H(+)/K(+) ATPase subunit alpha
proton pump
NP_001277556.1
NP_061201.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290627.1NP_001277556.1  potassium-transporting ATPase alpha chain 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC167978
    Consensus CDS
    CCDS71932.1
    UniProtKB/TrEMBL
    E9QNX7
    Related
    ENSMUSP00000005692, OTTMUSP00000052677, ENSMUST00000005692, OTTMUST00000094638
    Conserved Domains (7) summary
    pfam09040
    Location:227
    H-K_ATPase_N; Gastric H+/K+-ATPase, N terminal domain
    smart00831
    Location:50124
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    COG4087
    Location:616742
    COG4087; Soluble P-type ATPase [General function prediction only]
    pfam00122
    Location:156376
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:8091018
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam13246
    Location:436531
    Hydrolase_like2; Putative hydrolase of sodium-potassium ATPase alpha subunit
    TIGR01106
    Location:421034
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
  2. NM_018731.3NP_061201.2  potassium-transporting ATPase alpha chain 1 isoform 2

    See identical proteins and their annotated locations for NP_061201.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC167978
    Consensus CDS
    CCDS52182.1
    UniProtKB/TrEMBL
    Q91WH7
    Related
    ENSMUSP00000131964, OTTMUSP00000052678, ENSMUST00000170371, OTTMUST00000094639
    Conserved Domains (7) summary
    pfam09040
    Location:227
    H-K_ATPase_N; Gastric H+/K+-ATPase, N terminal domain
    smart00831
    Location:50124
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam00122
    Location:156376
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:8001009
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam12710
    Location:601727
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:436531
    Hydrolase_like2; Putative hydrolase of sodium-potassium ATPase alpha subunit
    TIGR01106
    Location:421025
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    30712209..30725534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    25294256..25307645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)