Format

Send to:

Choose Destination

SFR1 SWI5 dependent homologous recombination repair protein 1 [ Homo sapiens (human) ]

Gene ID: 119392, updated on 8-May-2016
Official Symbol
SFR1provided by HGNC
Official Full Name
SWI5 dependent homologous recombination repair protein 1provided by HGNC
Primary source
HGNC:HGNC:29574
See related
Ensembl:ENSG00000156384 HPRD:12590; MIM:616527; Vega:OTTHUMG00000019000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEI5; MEIR5; C10orf78; bA373N18.1
Orthologs
Location:
10q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (104122058..104126385)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (105880059..105886143)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene STE20 like kinase Neighboring gene collagen type XVII alpha 1 Neighboring gene microRNA 936 Neighboring gene cilia and flagella associated protein 43 Neighboring gene tropomyosin 3 pseudogene Neighboring gene microRNA 609

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ41960

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ligand-dependent nuclear receptor transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to estrogen stimulus IDA
Inferred from Direct Assay
more info
PubMed 
double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Swi5-Sfr1 complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
swi5-dependent recombination DNA repair protein 1 homolog
Names
MEI5 recombination repair protein homolog
SWI5-dependent homologous recombination repair protein 1
SWI5-dependent recombination repair 1
SWI5-dependent recombination repair protein 1
meiosis protein 5 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002759.1NP_001002759.1  swi5-dependent recombination DNA repair protein 1 homolog isoform a

    See identical proteins and their annotated locations for NP_001002759.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    BC020892, BC043256, BG942691
    Consensus CDS
    CCDS31279.1
    UniProtKB/Swiss-Prot
    Q86XK3
    Related
    ENSP00000358742, OTTHUMP00000020428, ENST00000369727, OTTHUMT00000050191
    Conserved Domains (1) summary
    pfam10376
    Location:25236
    Mei5; Double-strand recombination repair protein
  2. NM_145247.4NP_660290.3  swi5-dependent recombination DNA repair protein 1 homolog isoform b

    See identical proteins and their annotated locations for NP_660290.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    BC020892, BC043256, BE960638, CD694866
    Consensus CDS
    CCDS31280.1
    UniProtKB/Swiss-Prot
    Q86XK3
    Related
    ENSP00000358744, OTTHUMP00000020427, ENST00000369729, OTTHUMT00000050190
    Conserved Domains (1) summary
    pfam10376
    Location:12223
    Mei5; Double-strand recombination repair protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    104122058..104126385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269521.2XP_005269578.1  

    See identical proteins and their annotated locations for XP_005269578.1

    UniProtKB/Swiss-Prot
    Q86XK3
    Conserved Domains (1) summary
    pfam10376
    Location:87298
    Mei5; Double-strand recombination repair protein

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    106165698..106170024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)