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Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 [ Mus musculus (house mouse) ]

Gene ID: 11938, updated on 22-May-2016
Official Symbol
Atp2a2provided by MGI
Official Full Name
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2provided by MGI
Primary source
MGI:MGI:88110
See related
Ensembl:ENSMUSG00000029467 Vega:OTTMUSG00000054516
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SERCA2; SERCA2B; Serca2a; D5Wsu150e; mKIAA4195; 9530097L16Rik
Orthologs
Location:
5 62.38 cM; 5 F
Exon count:
21
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (122453513..122502225, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (122903522..122952234, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32853 Neighboring gene actin related protein 2/3 complex, subunit 3 Neighboring gene anaphase promoting complex subunit 7 Neighboring gene uncharacterized LOC102635658 Neighboring gene intraflagellar transport 81 Neighboring gene STIP1 homology and U-Box containing protein 1 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Alzheimer's disease, organism-specific biosystem (from KEGG)
    Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Alzheimer's disease, conserved biosystem (from KEGG)
    Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Cardiac conduction, organism-specific biosystem (from REACTOME)
    Cardiac conduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
    Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Cardiac muscle contraction, conserved biosystem (from KEGG)
    Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
    Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dilated cardiomyopathy, conserved biosystem (from KEGG)
    Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Ion channel transport, organism-specific biosystem (from REACTOME)
    Ion channel transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Ion homeostasis, organism-specific biosystem (from REACTOME)
    Ion homeostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Ion transport by P-type ATPases, organism-specific biosystem (from REACTOME)
    Ion transport by P-type ATPases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystem
    Myometrial Relaxation and Contraction Pathways
  • Pancreatic secretion, organism-specific biosystem (from KEGG)
    Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Pancreatic secretion, conserved biosystem (from KEGG)
    Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Platelet calcium homeostasis, organism-specific biosystem (from REACTOME)
    Platelet calcium homeostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Platelet homeostasis, organism-specific biosystem (from REACTOME)
    Platelet homeostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Reduction of cytosolic Ca++ levels, organism-specific biosystem (from REACTOME)
    Reduction of cytosolic Ca++ levels, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
    Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA4195

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
S100 protein binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
calcium-transporting ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
calcium-transporting ATPase activity ISO
Inferred from Sequence Orthology
more info
 
calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential ISO
Inferred from Sequence Orthology
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
lutropin-choriogonadotropic hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER-nucleus signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
T-tubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion import into sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport from cytosol to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle hypertrophy in response to stress IDA
Inferred from Direct Assay
more info
PubMed 
cellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cellular calcium ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
endoplasmic reticulum calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of heart contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
organelle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endoplasmic reticulum calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
regulation of calcium ion-dependent exocytosis of neurotransmitter IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cardiac muscle cell action potential involved in regulation of contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of cardiac muscle cell membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of cardiac muscle contraction by calcium ion signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of cardiac muscle contraction by calcium ion signaling ISO
Inferred from Sequence Orthology
more info
 
regulation of muscle contraction TAS
Traceable Author Statement
more info
PubMed 
regulation of the force of heart contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
relaxation of cardiac muscle ISO
Inferred from Sequence Orthology
more info
 
response to peptide hormone ISO
Inferred from Sequence Orthology
more info
 
sarcoplasmic reticulum calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
sarcoplasmic reticulum calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
transition between fast and slow fiber IDA
Inferred from Direct Assay
more info
PubMed 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
calcium ion-transporting ATPase complex ISO
Inferred from Sequence Orthology
more info
 
cell ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with intercalated disc ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
longitudinal sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
ribbon synapse IDA
Inferred from Direct Assay
more info
PubMed 
sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
sarcoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
sarcoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Names
SERCA2a isoform
SR Ca(2+)-ATPase 2
calcium pump 2
calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform
endoplasmic reticulum class 1/2 Ca(2+) ATPase
sarco/endoplasmic reticulum Ca2+-ATPase 2
NP_001103610.1
NP_033852.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110140.3NP_001103610.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b

    See identical proteins and their annotated locations for NP_001103610.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (b), also known as SERCA2B.
    Source sequence(s)
    AJ131821, AK220538, CF742600, CJ162528
    Consensus CDS
    CCDS57378.1
    UniProtKB/Swiss-Prot
    O55143
    UniProtKB/TrEMBL
    J3KMM5, Q5DTI2
    Related
    ENSMUSP00000031423, OTTMUSP00000071576, ENSMUST00000031423, OTTMUST00000135163
    Conserved Domains (6) summary
    pfam00122
    Location:93341
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:783986
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:597711
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:418527
    Hydrolase_like2; Putative hydrolase of sodium-potassium ATPase alpha subunit
    TIGR01116
    Location:53988
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
  2. NM_009722.3NP_033852.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a

    See identical proteins and their annotated locations for NP_033852.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (a), also known as SERCA2A, has a shorter and distinct C-terminus compared to isoform b.
    Source sequence(s)
    AK220538, BC054748, CJ162528
    Consensus CDS
    CCDS57379.1
    UniProtKB/Swiss-Prot
    O55143
    UniProtKB/TrEMBL
    Q5DTI2
    Related
    ENSMUSP00000136104, OTTMUSP00000071575, ENSMUST00000177974, OTTMUST00000135162
    Conserved Domains (6) summary
    pfam00122
    Location:93341
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:783986
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:597711
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:418527
    Hydrolase_like2; Putative hydrolase of sodium-potassium ATPase alpha subunit
    TIGR01116
    Location:53988
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

RNA

  1. NR_027838.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents a longer 3' UTR, compared to variant 1. This variant is represented as non-coding because the additional splicing in the 3' UTR renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK220538, BC054531, CJ162528

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    122453513..122502225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    119532083..119580718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)