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    CLIC1 chloride intracellular channel 1 [ Homo sapiens (human) ]

    Gene ID: 1192, updated on 9-Jun-2013
    Official Symbol
    CLIC1provided by HGNC
    Official Full Name
    chloride intracellular channel 1provided by HGNC
    Primary source
    HGNC:2062
    Locus tag
    DADB-110M10.1
    See related
    Ensembl:ENSG00000213719; HPRD:04188; MIM:602872; Vega:OTTHUMG00000031103
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G6; NCC27
    Summary
    Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]
    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (31698358..31704341, complement)
    See CLIC1 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene chromosome 6 open reading frame 25 Neighboring gene dimethylarginine dimethylaminohydrolase 2 Neighboring gene MSH5-SAPCD1 readthrough (NMD candidate) Neighboring gene mutS homolog 5 (E. coli) Neighboring gene suppressor APC domain containing 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.
    2. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. Wu Z, et al. PLoS One, 2012. PMID 22952844.
    3. Function of chloride intracellular channel 1 in gastric cancer cells. Ma PF, et al. World J Gastroenterol, 2012 Jun 28. PMID 22791942.
    4. Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment. Byron A, et al. Proteomics, 2012 Jul. PMID 22623428.
    5. Elevated expression of chloride intracellular channel 1 is correlated with poor prognosis in human gliomas. Wang L, et al. J Exp Clin Cancer Res, 2012 May 11. PMID 22578365.

    See all (66) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. the first evidence that CLIC1 expression might play an important role in the regulation of aggressiveness in human gliomas
      Title: Elevated expression of chloride intracellular channel 1 is correlated with poor prognosis in human gliomas.
    2. High CLIC1 expression can efficiently inhibit proliferation and enhance apoptosis, migration and invasion of gastric cancer cells in vitro.
      Title: Function of chloride intracellular channel 1 in gastric cancer cells.
    3. knockdown of PA28beta could enhance tumor invasion and metastasis, at least in part, through up-regulation of CLIC1 in gastric adenocarcinoma
      Title: PA28β regulates cell invasion of gastric cancer via modulating the expression of chloride intracellular channel 1.
    4. CLIC1 regulates the migration and invasion of colon cancer cells.
      Title: Regulation of colon cancer cell migration and invasion by CLIC1-mediated RVD.
    5. Both histidine (His)74 and His185 are involved in triggering pH changes to the conformational stability of wild-type CLIC1 via their protonation, which stabilizes the intermediate state.
      Title: Role of individual histidines in the pH-dependent global stability of human chloride intracellular channel 1.
    6. Intermolecular FRET data suggest that (1) N-terminal domain of CLIC1 inserts into bilayer as extended alpha-helix, (2) CLIC1 forms oligomer upon oxidation in presence of membranes, and (3) CLIC1 inserts into bilayer as oligomer of 6-8 subunits.
      Title: Transmembrane extension and oligomerization of the CLIC1 chloride intracellular channel protein upon membrane interaction.
    7. Data show that the expression of HSP27 and CLIC1 was strongly positive in 61 (59.2%) and 49 cases (47.6%), respectively.
      Title: The expression and clinical significance of CLIC1 and HSP27 in lung adenocarcinoma.
    8. Suppression of CLIC1 contributes to acquisition of the radioresistance phenotype of laryngeal cancer cells via inhibition of reactive oxygen species production.
      Title: Chloride intracellular channel 1 identified using proteomic analysis plays an important role in the radiosensitivity of HEp-2 cells via reactive oxygen species production.
    9. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    10. Consistent with previous findings, the N-terminal domain of CLIC1 is likely to insert into the lipid bilayer, while the C-domain remains in solution on the extravesicular side of the membrane
      Title: Metamorphic response of the CLIC1 chloride intracellular ion channel protein upon membrane interaction.
    Submit: New GeneRIF Correction See all (29)

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    O00299 Q99996 AKAP9    HPRD  PubMed  
    O00299 O15116 LSM1    HPRD  PubMed  
    O00299 Q99972 MYOC    HPRD  PubMed  
    O00299 Q6EEV6 SUMO4    HPRD  PubMed  
    O00299 O14582 TRAPPC2    HPRD  PubMed  
    BioGRID:107604 BioGRID:115445 AKAP9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107604 BioGRID:106742 ALOX5AP    BioGRID  PubMed Two-hybrid 
    BioGRID:107604 BioGRID:106902 ARRB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107604 BioGRID:107776 ATF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107604 BioGRID:107000 ATP5F1    BioGRID  PubMed Two-hybrid 
    BioGRID:107604 BioGRID:107018 ATP6V0A1    BioGRID  PubMed Two-hybrid 
    BioGRID:107604 BioGRID:107010 ATP6V0C    BioGRID  PubMed Two-hybrid 
    BioGRID:107604 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107604 BioGRID:107765 CPT1A    BioGRID  PubMed Two-hybrid 
    BioGRID:107604 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107604 BioGRID:108621 FN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107604 BioGRID:109127 GRK5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107604 BioGRID:114089 IKBKG    BioGRID  PubMed Two-hybrid 
    BioGRID:107604 BioGRID:114995 ISG15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107604 BioGRID:109883 ITGA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107604 BioGRID:118104 LSM1    BioGRID  PubMed Two-hybrid 
    BioGRID:107604 BioGRID:110736 MYOC    BioGRID  PubMed Two-hybrid 
    BioGRID:107604 BioGRID:110964 NTF4    BioGRID  PubMed Two-hybrid 
    BioGRID:107604 BioGRID:117165 NUP62    BioGRID  PubMed Two-hybrid 
    BioGRID:107604 BioGRID:115800 PRDX4    BioGRID  PubMed Two-hybrid 
    BioGRID:107604 BioGRID:112095 RPLP1    BioGRID  PubMed Two-hybrid 
    BioGRID:107604 BioGRID:132223 SUMO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107604 BioGRID:112923 THRA    BioGRID  PubMed Two-hybrid 
    BioGRID:107604 BioGRID:112299 TRAPPC2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107604 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107604 BioGRID:113255 VCAM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107604 BioGRID:113524 ZNF184    BioGRID  PubMed Two-hybrid 
    BioGRID:107604 BioGRID:120987 ZNF302    BioGRID  PubMed Two-hybrid 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    voltage-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    chloride transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    brush border TAS
    Traceable Author Statement
    more info
    		 PubMed 
    chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    chloride intracellular channel protein 1
    Names
    chloride intracellular channel protein 1
    hRNCC
    p64CLCP
    RNCC protein
    chloride channel ABP
    nuclear chloride ion channel 27
    nuclear chloride ion channel protein
    regulatory nuclear chloride ion channel protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001288.4 → NP_001279.2  chloride intracellular channel protein 1

      Status: REVIEWED

      Source sequence(s)
      BC064527, BM562536, X87689
      Consensus CDS
      CCDS4719.1
      UniProtKB/Swiss-Prot
      O00299
      UniProtKB/TrEMBL
      Q5SRT3
      Related
      ENSP00000364940, OTTHUMP00000029131, ENST00000375784, OTTHUMT00000076166
      Conserved Domains (3) summary
      cd03061
      Location:3 – 93
      Blast Score: 386
      GST_N_CLIC; GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated ...
      TIGR00862
      Location:6 – 241
      Blast Score: 1162
      O-ClC; intracellular chloride channel protein
      cd10300
      Location:100 – 238
      Blast Score: 716
      GST_C_CLIC1; C-terminal, alpha helical domain of Chloride Intracellular Channel 1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.2 Reference GRCh37.p10 ALT_REF_LOCI_2

      Range
      3207975..3213962, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.1 Reference GRCh37.p10 ALT_REF_LOCI_3

      Range
      2983927..2989912, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.1 Reference GRCh37.p10 ALT_REF_LOCI_4

      Range
      3041248..3047235, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.1 Reference GRCh37.p10 ALT_REF_LOCI_5

      Range
      3078041..3084028, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.1 Reference GRCh37.p10 ALT_REF_LOCI_6

      Range
      2991988..2997979, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.1 Reference GRCh37.p10 ALT_REF_LOCI_7

      Range
      3029175..3035164, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p10 Primary Assembly

      Range
      31698358..31704341, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      31484582..31490568, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018917.1 Alternate CHM1_1.0

      Range
      31615312..31621297, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01038084.1 (87872..93858) None
    genomic AF129756.1 AAD18073.1
    genomic AJ012008.1 CAB46078.1
    genomic AL662899.5 (72921..78904) None
    genomic AL670886.6 (83234..89221) None
    genomic AL844216.3 (21936..27927) None
    genomic AMYH01016217.1 (232103..238088) None
    genomic BA000025.2 BAB63376.1
    genomic BX248244.7 (43136..49125) None
    genomic CH471081.1 EAX03503.1
      EAX03504.1
      EAX03505.1
    genomic CR354443.4 (111691..117678) None
    genomic CR759787.4 (37192..43179) None
    genomic CR936239.2 (21025..27010) None
    mRNA AF034607.1 AAD20437.1
    mRNA AF109197.1 AAD26137.1
    mRNA AK129773.1 None
    mRNA AK223379.1 BAD97099.1
    mRNA AK314014.1 BAG36725.1
    mRNA BC064527.1 AAH64527.1
    mRNA BC095469.1 AAH95469.1
    mRNA BM562536.1 None
    mRNA CR542071.1 CAG46868.1
    mRNA U93205.1 AAC25675.1
    mRNA X87689.1 CAA61020.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00299.4 GenPept UniProtKB/Swiss-Prot:O00299

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials
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      Supplemental Content

      Table of contents

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      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
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        Link to related EST entry
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        PMC links
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        Full text in PubMedCentral identified from shared sequence links
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        Genome records having the gene annotated on corresponding genomic reference sequence.
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      • HomoloGene
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        Link to related Nucleotide entry
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        Related Probe entry
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      • PubChem Compound
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      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
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        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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