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    CLIC1 chloride intracellular channel 1 [ Homo sapiens ]

    Gene ID: 1192, updated on 11-May-2012
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    Summary

    Official Symbol
    CLIC1provided by HGNC
    Official Full Name
    chloride intracellular channel 1provided by HGNC
    Primary source
    HGNC:2062
    Locus tag
    DADB-110M10.1
    See related
    Ensembl:ENSG00000213719; HPRD:04188; MIM:602872; Vega:OTTHUMG00000031103
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G6; NCC27
    Summary
    Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (31698358..31704341, complement)
    See CLIC1 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene chromosome 6 open reading frame 25 Neighboring gene dimethylarginine dimethylaminohydrolase 2 Neighboring gene MSH5-SAPCD1 readthrough (non-protein coding) Neighboring gene mutS homolog 5 (E. coli) Neighboring gene suppressor APC domain containing 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Role of individual histidines in the pH-dependent global stability of human chloride intracellular channel 1. Achilonu I, et al. Biochemistry, 2012 Feb 7. PMID 22242893.
    2. Transmembrane extension and oligomerization of the CLIC1 chloride intracellular channel protein upon membrane interaction. Goodchild SC, et al. Biochemistry, 2011 Dec 20. PMID 22082111.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. The expression and clinical significance of CLIC1 and HSP27 in lung adenocarcinoma. Wang W, et al. Tumour Biol, 2011 Dec. PMID 21858536.

    See all (51) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Both histidine (His)74 and His185 are involved in triggering pH changes to the conformational stability of wild-type CLIC1 via their protonation, which stabilizes the intermediate state.
      Title: Role of individual histidines in the pH-dependent global stability of human chloride intracellular channel 1.
    2. Intermolecular FRET data suggest that (1) N-terminal domain of CLIC1 inserts into bilayer as extended alpha-helix, (2) CLIC1 forms oligomer upon oxidation in presence of membranes, and (3) CLIC1 inserts into bilayer as oligomer of 6-8 subunits.
      Title: Transmembrane extension and oligomerization of the CLIC1 chloride intracellular channel protein upon membrane interaction.
    3. Data show that the expression of HSP27 and CLIC1 was strongly positive in 61 (59.2%) and 49 cases (47.6%), respectively.
      Title: The expression and clinical significance of CLIC1 and HSP27 in lung adenocarcinoma.
    4. Suppression of CLIC1 contributes to acquisition of the radioresistance phenotype of laryngeal cancer cells via inhibition of reactive oxygen species production.
      Title: Chloride intracellular channel 1 identified using proteomic analysis plays an important role in the radiosensitivity of HEp-2 cells via reactive oxygen species production.
    5. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    6. Consistent with previous findings, the N-terminal domain of CLIC1 is likely to insert into the lipid bilayer, while the C-domain remains in solution on the extravesicular side of the membrane
      Title: Metamorphic response of the CLIC1 chloride intracellular ion channel protein upon membrane interaction.
    7. statistical analysis of CLIC1 level in plasma shows that CLIC1 could be applied as a marker for early detection of nasopharyngeal carcinoma
      Title: Cell secretome analysis using hollow fiber culture system leads to the discovery of CLIC1 protein as a novel plasma marker for nasopharyngeal carcinoma.
    8. CLIC1 may play a role in the regulation of osteoblastic differentiation from mesenchymal progenitors, although its physiologic role in osteoblasts remains to be determined.
      Title: Chloride intracellular channel 1 regulates osteoblast differentiation.
    9. Overexpression of CLIC1 promoted cell motility & invasion of gallbladder carcinoma cell lines in vitro, while RNA interference of CLIC1 remarkably decreased these. CLIC1 might play an important role in metastasis of gallbladder carcinoma.
      Title: Identification of metastasis-associated proteins involved in gallbladder carcinoma metastasis by proteomic analysis and functional exploration of chloride intracellular channel 1.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection.
    Submit: New GeneRIF Correction See all (25)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O00299 Q99996 AKAP9    HPRD  PubMed  
    O00299 O15116 LSM1    HPRD  PubMed  
    O00299 Q99972 MYOC    HPRD  PubMed  
    O00299 Q6EEV6 SUMO4    HPRD  PubMed  
    O00299 O14582 TRAPPC2    HPRD  PubMed  
    BioGRID:107604 BioGRID:115445 AKAP9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107604 BioGRID:118104 LSM1    BioGRID  PubMed Two-hybrid 
    BioGRID:107604 BioGRID:132223 SUMO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107604 BioGRID:112299 TRAPPC2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107604 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    voltage-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    voltage-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    chloride transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chloride transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    brush border TAS
    Traceable Author Statement
    more info
    		 PubMed 
    chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane fraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    soluble fraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    chloride intracellular channel protein 1
    Names
    chloride intracellular channel protein 1
    hRNCC
    p64CLCP
    RNCC protein
    chloride channel ABP
    nuclear chloride ion channel 27
    nuclear chloride ion channel protein
    regulatory nuclear chloride ion channel protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001288.4 → NP_001279.2  chloride intracellular channel protein 1

      Status: REVIEWED

      Source sequence(s)
      BC064527, BM562536, X87689
      Consensus CDS
      CCDS4719.1
      UniProtKB/Swiss-Prot
      O00299
      UniProtKB/TrEMBL
      Q5SRT3
      Related
      ENSP00000364940, OTTHUMP00000029131, ENST00000375784, OTTHUMT00000076166
      Conserved Domains (3) summary
      cd03061
      Location:3 – 93
      Blast Score: 386
      GST_N_CLIC; GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated ...
      TIGR00862
      Location:6 – 241
      Blast Score: 1162
      O-ClC; intracellular chloride channel protein
      cd10300
      Location:100 – 238
      Blast Score: 716
      GST_C_CLIC1; C-terminal, alpha helical domain of Chloride Intracellular Channel 1

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      31698358..31704341, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.2 Reference GRCh37.p5 ALT_REF_LOCI_2

      Range
      3207975..3213962, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.1 Reference GRCh37.p5 ALT_REF_LOCI_3

      Range
      2983927..2989912, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.1 Reference GRCh37.p5 ALT_REF_LOCI_4

      Range
      3041248..3047235, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.1 Reference GRCh37.p5 ALT_REF_LOCI_5

      Range
      3078041..3084028, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.1 Reference GRCh37.p5 ALT_REF_LOCI_6

      Range
      2991988..2997979, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.1 Reference GRCh37.p5 ALT_REF_LOCI_7

      Range
      3029175..3035164, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      31484582..31490568, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF129756.1 AAD18073.1
    genomic AJ012008.1 CAB46078.1
    genomic AL662899.5 (72920..78903) None
    genomic AL670886.6 (83233..89220) None
    genomic AL844216.3 CAM45776.1
    genomic BA000025.2 BAB63376.1
    genomic BX248244.7 CAM26101.1
    genomic CH471081.1 EAX03503.1
      EAX03504.1
      EAX03505.1
    genomic CR354443.4 CAQ07026.1
    genomic CR759787.4 CAQ10114.1
    genomic CR936239.2 CAQ08899.1
    mRNA AF034607.1 AAD20437.1
    mRNA AF109197.1 AAD26137.1
    mRNA AK129773.1 None
    mRNA AK223379.1 BAD97099.1
    mRNA AK314014.1 BAG36725.1
    mRNA BC064527.1 AAH64527.1
    mRNA BC095469.1 AAH95469.1
    mRNA BM562536.1 None
    mRNA CR542071.1 CAG46868.1
    mRNA U93205.1 AAC25675.1
    mRNA X87689.1 CAA61020.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00299.4 GenPept UniProtKB/Swiss-Prot:O00299
    Q53FB0 GenPept UniProtKB/TrEMBL:Q53FB0
    Q5SRT3 GenPept UniProtKB/TrEMBL:Q5SRT3
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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