Atf2 activating transcription factor 2 [Mus musculus] - Gene

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Summary

Official Symbol: Atf2provided by MGI
Official Full Name: activating transcription factor 2provided by MGI
Primary source: MGI:109349
Locus tag: RP23-290B1.2
See related: Ensembl:ENSMUSG00000027104; Vega:OTTMUSG00000013179
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mXBP; Atf-2; Creb2; CRE-BP; D18875; D130078H02Rik; MGC105211; MGC105222; Tg(Gzma-Klra1)7Wum

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Genomic context

Location :: 2 C3; 2

Sequence :: Chromosome: 2; NC_000068.7 (73816521..73892628, complement)

See Atf2 in Epigenomics, MapViewer

Chromosome 2 - NC_000068.7 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ATF2 has a critical role in limiting the activities of stress kinases JNK and p38 which are potent inducers of cell death in the CNS
Title: Loss of ATF2 function leads to cranial motoneuron degeneration during embryonic mouse development.
ATF2 interacts with beta-cell-enriched transcription factors, MafA, Pdx1, and beta2, and activates insulin gene transcription.
Title: ATF2 interacts with beta-cell-enriched transcription factors, MafA, Pdx1, and beta2, and activates insulin gene transcription.
MITF is downregulated by ATF2 in the skin of Atf2-/- mice, in primary human melanocytes, and in melanoma cell lines.
Title: A role for ATF2 in regulating MITF and melanoma development.
Growth factor-independent signaling pathways converge in the formation of an active c-Jun.AFT2 dimer, which induces the expression of the anti-apoptotic factor Bcl-X(L) that mediates a pro-survival response.
Title: Growth factor stimulation induces cell survival by c-Jun. ATF2-dependent activation of Bcl-XL.
Data show that ATF-2 was rapidly phosphorylated and recruited to the Tnfa promoter following ligation of TLR2.
Title: The neuropeptide calcitonin gene-related peptide causes repression of tumor necrosis factor-alpha transcription and suppression of ATF-2 promoter recruitment in Toll-like receptor-stimulated dendritic cells.
The sequential nuclear appearance of ERK1/2 and p38 determines the induction of ATF2-Thr71 and ATF2-Thr69+71-phosphorylation in response to serum.
Title: The nuclear appearance of ERK1/2 and p38 determines the sequential induction of ATF2-Thr71 and ATF2-Thr69 phosphorylation by serum in JNK-deficient cells.
Data reveal a new signaling pathway activated by amino acid starvation leading to ATF2 phosphorylation and subsequently positively affecting the transcription of amino acid-regulated genes.
Title: Identification of a novel amino acid response pathway triggering ATF2 phosphorylation in mammals.
ATF-2 plays an important role in TLR-mediated transcriptional control in macrophage cells.
Title: ATF-2 regulates lipopolysaccharide-induced transcription in macrophage cells.
the phosphorylation of ATF-2 at Ser-121 plays a key role in the c-Jun-mediated activation of transcription that occurs in response to TPA.
Title: Phosphorylation of Activation Transcription Factor-2 at Serine 121 by Protein Kinase C Controls c-Jun-mediated Activation of Transcription.
Data indicate that the ATF3 gene is a bona fide target gene of ATF2 in gonadotrophs.
Title: Expression of the transcriptional repressor ATF3 in gonadotrophs is regulated by Egr-1, CREB, and ATF2 after gonadotropin-releasing hormone receptor stimulation.

Submit: New GeneRIF Correction See all (30)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (3) 1 citation
Targeted (knock-in) (1) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_033845.1	NC_000067.2	Atf3	BIND	PubMed	ATF2 interacts with ATF3 promoter.
NP_033845.1	NP_038828.1	Barx2	BIND	PubMed	Barx2 interacts with Atf2.
NP_033845.1	NC_000069.2	Ccna2	BIND	PubMed	ATF2 interacts with CcnA promoter.
NP_033845.1	NP_035291.3	Mapk11	BIND	PubMed	Mapk11 (p38-beta) interacts with and phosphorylates Atf2 (ATF-2). This interaction was modeled on a demonstrated interaction between mouse p38-beta and human ATF-2.
NP_033845.1	NP_036081.1	Mapk14	BIND	PubMed	Mapk14 (p38) interacts with and phosphorylates Atf2 (ATF-2). This interaction was modelled on a demonstrated interaction between mouse p38 and human ATF-2.
NP_033845.1	NP_036081.1	Mapk14	BIND	PubMed	p38 interacts with ATF2.
NP_033845.1	NP_036081.1	Mapk14	BIND	PubMed	Mapk14 (p38) interacts with and phosphorylates Atf2 (ATF-2). This interaction was modelled on a demonstrated interaction between mouse p38 and human ATF-2.
NP_033845.1	NP_036081.1	Mapk14	BIND	PubMed	p38 interacts with and phosphorylates ATF-2. This interaction was modeled on a demonstrated interaction between rabbit or mouse p38 and human ATF-2.
NP_033845.1	NP_036081.1	Mapk14	BIND	PubMed	Mapk14 (p38) phosphorylates Atf2 (ATF-2). This interaction was modeled on a demonstrated interaction between mouse Mapk14 and Atf2 from an unspecified species.
NP_033845.1	NP_057909.1	Mapk8	BIND	PubMed	JNK1 interacts with ATF2.
BioGRID:198233	BioGRID:198233	Atf2	BioGRID	PubMed	Reconstituted Complex
BioGRID:198233	BioGRID:198303	Barx2	BioGRID	PubMed	Two-hybrid
BioGRID:198233	BioGRID:236625	Ep300	BioGRID	PubMed	Co-purification
BioGRID:198233	BioGRID:219888	Jdp2	BioGRID	PubMed	Reconstituted Complex
BioGRID:198233	BioGRID:202313	Pou5f1	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
RNA polymerase II activating transcription factor binding	ISO Inferred from Sequence Orthology more info
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IDA Inferred from Direct Assay more info	PubMed
RNA polymerase II distal enhancer sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
cAMP response element binding	ISO Inferred from Sequence Orthology more info
cAMP response element binding protein binding	ISO Inferred from Sequence Orthology more info
chromatin binding	IDA Inferred from Direct Assay more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
nucleic acid binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein dimerization activity	IEA Inferred from Electronic Annotation more info
protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
protein kinase binding	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
adipose tissue development	IGI Inferred from Genetic Interaction more info	PubMed
fat cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of transforming growth factor beta2 production	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
response to osmotic stress	ISO Inferred from Sequence Orthology more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
intracellular	IEA Inferred from Electronic Annotation more info
membrane fraction	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

Preferred Names: cyclic AMP-dependent transcription factor ATF-2

Names: cyclic AMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; cAMP response element-binding protein CRE-BP1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025093.1 → NP_001020264.1 cyclic AMP-dependent transcription factor ATF-2 isoform 1

Status: VALIDATED

Source sequence(s)

AK051591, BC079883, BC082596

Consensus CDS

CCDS16134.1

UniProtKB/TrEMBL

A2AQF2

UniProtKB/Swiss-Prot

P16951

UniProtKB/TrEMBL

Q543G2

UniProtKB/TrEMBL

Q640L6

UniProtKB/TrEMBL

Q68FE3

Related

ENSMUSP00000058521, OTTMUSP00000014184, ENSMUST00000055833, OTTMUST00000031835

Conserved Domains (1) summary

cl02576
Location:333 – 396
Blast Score: 201

bZIP_1; bZIP transcription factor
NM_009715.2 → NP_033845.1 cyclic AMP-dependent transcription factor ATF-2 isoform 2

Status: VALIDATED

Source sequence(s)

AK051591, BC079883

Consensus CDS

CCDS16135.1

UniProtKB/TrEMBL

Q543G2

UniProtKB/TrEMBL

Q68FE3

Related

ENSMUSP00000107638, OTTMUSP00000014181, ENSMUST00000112007, OTTMUST00000031832

Conserved Domains (1) summary

cl02576
Location:293 – 356
Blast Score: 201

bZIP_1; bZIP transcription factor

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000068.7 Reference GRCm38 C57BL/6J

Range

73816521..73892628, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000024.1 Alternate Mm_Celera

Range

75503543..75579494, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AL844581.7	CAM15299.1
		CAM15300.1
		CAM15301.1
		CAM15302.1
		CAM15303.1
		CAM15304.1
genomic	AL845523.6	CAM19861.1
		CAM19862.1
genomic	CH466519.1	EDL27148.1	mixed
		EDL27149.1	mixed
		EDL27150.1	mixed
		EDL27151.1	mixed
		EDL27152.1	mixed
		EDL27153.1	mixed
mRNA	AF483482.1	AAL90756.1	ILS
mRNA	AF483483.1	AAL90757.1	ISS
mRNA	AK035438.1	BAC29065.1	C57BL/6J
mRNA	AK041145.1	None	C57BL/6J
mRNA	AK046184.1	BAC32623.1	C57BL/6J
mRNA	AK047405.1	None	C57BL/6J
mRNA	AK051591.1	BAC34684.1	C57BL/6J
mRNA	AK087424.1	BAC39869.1	C57BL/6J
mRNA	AK139515.1	None	C57BL/6J
mRNA	AK139844.1	BAE24156.1	C57BL/6J
mRNA	AK140855.1	BAE24498.1	C57BL/6J
mRNA	AK144977.1	None
mRNA	AK145887.1	BAE26726.1	C57BL/6J
mRNA	AK146839.1	None	C57BL/6J
mRNA	AY902311.1	AAX83926.1	CAST/EiJ
mRNA	BC042210.1	AAH42210.1	CZECHII
mRNA	BC079883.1	AAH79883.1	C57BL/6
mRNA	BC082596.1	AAH82596.1	C57BL/6
mRNA	BC085137.1	None	C57BL/6
mRNA	M31629.1	AAA39780.1
mRNA	M77167.1	AAA40394.1
mRNA	S76655.1	AAB21127.1
mRNA	S76657.1	AAB21128.1
mRNA	S76659.1	AAB21129.1
mRNA	U46026.1	AAB64016.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P16951.2	GenPept	UniProtKB/Swiss-Prot:P16951
P70299	GenPept	UniProtKB/TrEMBL:P70299
Q3UKS5	GenPept	UniProtKB/TrEMBL:Q3UKS5
Q3US39	GenPept	UniProtKB/TrEMBL:Q3US39
Q3UT24	GenPept	UniProtKB/TrEMBL:Q3UT24
Q543G2	GenPept	UniProtKB/TrEMBL:Q543G2
Q640L6	GenPept	UniProtKB/TrEMBL:Q640L6
Q68FE3	GenPept	UniProtKB/TrEMBL:Q68FE3
Q8BN75	GenPept	UniProtKB/TrEMBL:Q8BN75
Q8BQY2	GenPept	UniProtKB/TrEMBL:Q8BQY2
Q8CBR9	GenPept	UniProtKB/TrEMBL:Q8CBR9
Q8CGB4	GenPept	UniProtKB/TrEMBL:Q8CGB4