Format

Send to:

Choose Destination

Arntl aryl hydrocarbon receptor nuclear translocator-like [ Mus musculus (house mouse) ]

Gene ID: 11865, updated on 29-May-2016
Official Symbol
Arntlprovided by MGI
Official Full Name
aryl hydrocarbon receptor nuclear translocator-likeprovided by MGI
Primary source
MGI:MGI:1096381
See related
Ensembl:ENSMUSG00000055116
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MOP3; Arnt3; Bmal1; BMAL1b; bHLHe5; bmal1b'
Summary
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with Clock. This heterodimer binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]
Orthologs
Location:
7 59.17 cM; 7 F2-F3
Exon count:
24
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (113178473..113314126)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (120350979..120457636)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930543E12 gene Neighboring gene predicted gene, 33659 Neighboring gene predicted gene, 33721 Neighboring gene BTB (POZ) domain containing 10 Neighboring gene parathyroid hormone

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
E-box binding ISO
Inferred from Sequence Orthology
more info
 
Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
aryl hydrocarbon receptor binding ISO
Inferred from Sequence Orthology
more info
 
bHLH transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
core promoter binding IDA
Inferred from Direct Assay
more info
PubMed 
core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
repressing transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor activity, sequence-specific DNA binding ISA
Inferred from Sequence Alignment
more info
PubMed 
transcription factor binding ISA
Inferred from Sequence Alignment
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IC
Inferred by Curator
more info
PubMed 
transcriptional activator activity, RNA polymerase II transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
maternal process involved in parturition IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of glucocorticoid receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
oxidative stress-induced premature senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein import into nucleus, translocation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of hair cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of type B pancreatic cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to redox state IDA
Inferred from Direct Assay
more info
PubMed 
response to redox state ISO
Inferred from Sequence Orthology
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatoid body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
aryl hydrocarbon receptor nuclear translocator-like protein 1
Names
brain and muscle ARNT-like 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243048.1NP_001229977.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001229977.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several in-frame exons in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC156605, AK147145, BQ030833
    UniProtKB/Swiss-Prot
    Q9WTL8
    UniProtKB/TrEMBL
    Q3UHZ2
    Conserved Domains (4) summary
    cd00083
    Location:58113
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:328423
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:133240
    PAS; PAS fold
    pfam14598
    Location:326428
    PAS_11; PAS domain
  2. NM_007489.4NP_031515.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_031515.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest variant and encodes the longest isoform (1).
    Source sequence(s)
    AC156605, AK147145, BQ030833
    Consensus CDS
    CCDS40092.1
    UniProtKB/Swiss-Prot
    Q9WTL8
    UniProtKB/TrEMBL
    Q3UHZ2
    Related
    ENSMUSP00000046235, ENSMUST00000047321
    Conserved Domains (4) summary
    cd00083
    Location:71126
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:341436
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:146253
    PAS; PAS fold
    pfam14598
    Location:339441
    PAS_11; PAS domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    113178473..113314126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507246.2XP_006507309.1  

    See identical proteins and their annotated locations for XP_006507309.1

    Conserved Domains (4) summary
    cd00083
    Location:78133
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:348443
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:153260
    PAS; PAS fold
    pfam14598
    Location:346448
    PAS_11; PAS domain
  2. XM_006507248.2XP_006507311.1  

    See identical proteins and their annotated locations for XP_006507311.1

    Conserved Domains (4) summary
    cd00083
    Location:78133
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:348443
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:153260
    PAS; PAS fold
    pfam14598
    Location:346448
    PAS_11; PAS domain
  3. XM_006507245.1XP_006507308.1  

    See identical proteins and their annotated locations for XP_006507308.1

    Conserved Domains (4) summary
    cd00083
    Location:78133
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:348443
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:153260
    PAS; PAS fold
    pfam14598
    Location:346448
    PAS_11; PAS domain
  4. XM_006507249.1XP_006507312.1  

    Conserved Domains (4) summary
    cd00083
    Location:78133
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:347442
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:153260
    PAS; PAS fold
    pfam14598
    Location:345447
    PAS_11; PAS domain
  5. XM_006507253.2XP_006507316.1  

    Conserved Domains (4) summary
    cd00083
    Location:71126
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:340435
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:146253
    PAS; PAS fold
    pfam14598
    Location:338440
    PAS_11; PAS domain
  6. XM_011241656.1XP_011239958.1  

    See identical proteins and their annotated locations for XP_011239958.1

    Conserved Domains (4) summary
    cd00083
    Location:78133
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:348443
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:153260
    PAS; PAS fold
    pfam14598
    Location:346448
    PAS_11; PAS domain
  7. XM_006507251.2XP_006507314.1  

    See identical proteins and their annotated locations for XP_006507314.1

    UniProtKB/Swiss-Prot
    Q9WTL8
    Conserved Domains (4) summary
    cd00083
    Location:78133
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:347442
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:153260
    PAS; PAS fold
    pfam14598
    Location:345447
    PAS_11; PAS domain
  8. XM_006507252.1XP_006507315.1  

    Conserved Domains (4) summary
    cd00083
    Location:71126
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:341436
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:146253
    PAS; PAS fold
    pfam14598
    Location:339441
    PAS_11; PAS domain
  9. XM_006507250.1XP_006507313.1  

    Conserved Domains (4) summary
    cd00083
    Location:78133
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:348443
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:153260
    PAS; PAS fold
    pfam14598
    Location:346448
    PAS_11; PAS domain
  10. XM_006507247.2XP_006507310.1  

    See identical proteins and their annotated locations for XP_006507310.1

    Conserved Domains (4) summary
    cd00083
    Location:78133
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:348443
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:153260
    PAS; PAS fold
    pfam14598
    Location:346448
    PAS_11; PAS domain

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    113186397..113287839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)