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    C10orf90 chromosome 10 open reading frame 90 [ Homo sapiens ]

    Gene ID: 118611, updated on 11-May-2012
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    Summary

    Official Symbol
    C10orf90provided by HGNC
    Official Full Name
    chromosome 10 open reading frame 90provided by HGNC
    Primary source
    HGNC:26563
    Locus tag
    RP11-422P15.2
    See related
    Ensembl:ENSG00000154493; HPRD:16587; Vega:OTTHUMG00000019245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FATS; bA422P15.2; FLJ32938; RP11-422P15.2
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    Genomic context

    Location :
    10q26.2
    Sequence :
    Chromosome: 10; NC_000010.10 (128113571..128210010, complement)
    See C10orf90 in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), gamma 10 pseudogene Neighboring gene fibronectin type III and ankyrin repeat domains 1 Neighboring gene ADAM metallopeptidase domain 12 Neighboring gene SAR1 homolog A (S. cerevisiae) pseudogene 2 Neighboring gene uncharacterized LOC728065 Neighboring gene dedicator of cytokinesis 1 Neighboring gene family with sequence similarity 196, member A

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Expression level of novel tumor suppressor gene FATS is associated with the outcome of node positive breast cancer. Zhang J, et al. Chin Med J (Engl), 2011 Sep. PMID 22040499.
    2. Centriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731. Knorz VJ, et al. Mol Biol Cell, 2010 Nov 1. PMID 20844083.
    3. FATS is a transcriptional target of p53 and associated with antitumor activity. Zhang X, et al. Mol Cancer, 2010 Sep 16. PMID 20843368.
    4. An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis. Li Z, et al. Oncogene, 2010 May 6. PMID 20154723.
    5. Large-scale analysis of the human ubiquitin-related proteome. Matsumoto M, et al. Proteomics, 2005 Nov. PMID 16196087.

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. FATS is involved in the carcinogenesis and development of breast cancer and could be a potential biomarker and prognostic factor for breast cancer therapy.
      Title: Expression level of novel tumor suppressor gene FATS is associated with the outcome of node positive breast cancer.
    2. data suggest centrosomal functions for C10orf90 and KIAA1731 and new centriole-related functions for ALMS1
      Title: Centriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:125615 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    mitotic cell cycle G2/M transition DNA damage checkpoint IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein stabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to UV IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to ionizing radiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    centrosome IDA
    Inferred from Direct Assay
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
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    General protein information

    Preferred Names
    centrosomal protein C10orf90
    Names
    centrosomal protein C10orf90
    fragile-site associated tumor suppressor homolog
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004298.2 → NP_001004298.2  centrosomal protein C10orf90

      Status: VALIDATED

      Source sequence(s)
      AK057500, AL589787, AL705062, BC021140, BC034828
      Consensus CDS
      CCDS31310.1
      UniProtKB/Swiss-Prot
      Q96M02
      Related
      ENSP00000284694, ENST00000284694

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      128113571..128210010, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      121800854..121897275, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL583860.7 CAI12407.1
      CAI12408.1
      CAI12409.1
    genomic AL589787.16 CAI40678.1
      CAI40679.1
      CAI40680.1
      CAI40684.1
    genomic CH471066.2 EAW49200.1
      EAW49201.1
      EAW49202.1
    mRNA AF435960.1 AAM20911.1
    mRNA AK057500.1 BAB71512.1
    mRNA AK093093.1 None
    mRNA AK297577.1 BAG59968.1
    mRNA AK308357.1 None
    mRNA AK309217.1 None
    mRNA AL705062.1 None
    mRNA BC021140.1 AAH21140.1
    mRNA BC034828.1 None
    mRNA BC140898.1 AAI40899.1
    mRNA BC146869.1 AAI46870.1
    other-genetic BC156058.1 AAI56059.1
    other-genetic BC156941.1 AAI56942.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T024 GenPept UniProtKB/TrEMBL:Q5T024
    Q5T025 GenPept UniProtKB/TrEMBL:Q5T025
    Q96M02.2 GenPept UniProtKB/Swiss-Prot:Q96M02
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
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      Supplemental Content

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