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Arf6 ADP-ribosylation factor 6 [ Mus musculus (house mouse) ]

Gene ID: 11845, updated on 28-May-2016
Official Symbol
Arf6provided by MGI
Official Full Name
ADP-ribosylation factor 6provided by MGI
Primary source
MGI:MGI:99435
See related
Ensembl:ENSMUSG00000044147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI788669; AW496366
Orthologs
Location:
12; 12 C2
Exon count:
2
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 12 NC_000078.6 (69372150..69375980)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (70473137..70476967)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene 7S RNA 2 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene RIKEN cDNA 5830428M24 gene Neighboring gene predicted gene, 40434

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
    Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
  • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
    Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystem
    Insulin Signaling
  • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
    Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
    Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC102530

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTP binding TAS
Traceable Author Statement
more info
PubMed 
GTPase activity TAS
Traceable Author Statement
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thioesterase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
establishment of epithelial cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
hepatocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
myeloid cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of establishment of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to endosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to endosome ISO
Inferred from Sequence Orthology
more info
 
protein transport TAS
Traceable Author Statement
more info
PubMed 
regulation of Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of toll-like receptor 4 signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
ruffle organization ISO
Inferred from Sequence Orthology
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cell cortex ISO
Inferred from Sequence Orthology
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
early endosome ISO
Inferred from Sequence Orthology
more info
 
endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
endosome ISO
Inferred from Sequence Orthology
more info
 
endosome TAS
Traceable Author Statement
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
filopodium membrane ISO
Inferred from Sequence Orthology
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
recycling endosome ISO
Inferred from Sequence Orthology
more info
 
recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
 
ruffle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
ADP-ribosylation factor 6
NP_031507.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007481.3NP_031507.1  ADP-ribosylation factor 6

    See identical proteins and their annotated locations for NP_031507.1

    Status: VALIDATED

    Source sequence(s)
    AC157822, AV587828, CJ167311
    Consensus CDS
    CCDS25952.1
    UniProtKB/Swiss-Prot
    P62331
    UniProtKB/TrEMBL
    Q3U0D7
    Related
    ENSMUSP00000055862, ENSMUST00000050063
    Conserved Domains (2) summary
    cd04149
    Location:5172
    Arf6; ADP ribosylation factor 6 (Arf6)
    TIGR00231
    Location:13157
    small_GTP; small GTP-binding protein domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p3 C57BL/6J

    Range
    69372150..69375980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000034.1 Alternate Mm_Celera

    Range
    70470421..70474282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)