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OLFM3 olfactomedin 3 [ Homo sapiens (human) ]

Gene ID: 118427, updated on 26-May-2016
Official Symbol
OLFM3provided by HGNC
Official Full Name
olfactomedin 3provided by HGNC
Primary source
HGNC:HGNC:17990
See related
Ensembl:ENSG00000118733 MIM:607567; Vega:OTTHUMG00000010941
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOE3; NOELIN3; OPTIMEDIN
Orthologs
Location:
1p22
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (101802567..101997234, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (102268126..102462790, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378872 Neighboring gene ribosomal protein SA pseudogene 19 Neighboring gene DnaJ heat shock protein family (Hsp40) member A1 pseudogene 5 Neighboring gene uncharacterized LOC105378873 Neighboring gene uncharacterized LOC105378874

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
eye photoreceptor cell development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
AMPA glutamate receptor complex IEA
Inferred from Electronic Annotation
more info
 
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
noelin-3
Names
olfactomedin related ER localized protein 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288821.1NP_001275750.1  noelin-3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001275750.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF397392, AK095551, AK300870, HY346025
    Consensus CDS
    CCDS72832.1
    UniProtKB/Swiss-Prot
    Q96PB7
    UniProtKB/TrEMBL
    B3KTG9, Q6IMJ0
    Related
    ENSP00000345192, OTTHUMP00000012613, ENST00000338858, OTTHUMT00000030142
    Conserved Domains (2) summary
    pfam12308
    Location:45145
    Noelin-1; Neurogenesis glycoprotein
    pfam02191
    Location:222470
    OLF; Olfactomedin-like domain
  2. NM_001288823.1NP_001275752.1  noelin-3 isoform 3

    See identical proteins and their annotated locations for NP_001275752.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AF397396, AK095551, DA528521, HY346025
    UniProtKB/Swiss-Prot
    Q96PB7
    UniProtKB/TrEMBL
    B3KTG9
    Conserved Domains (2) summary
    pfam12308
    Location:150
    Noelin-1; Neurogenesis glycoprotein
    pfam02191
    Location:127375
    OLF; Olfactomedin-like domain
  3. NM_058170.3NP_477518.2  noelin-3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_477518.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF397393, AK095551, BC022531, DA528521, HY346025
    Consensus CDS
    CCDS30781.1
    UniProtKB/Swiss-Prot
    Q96PB7
    UniProtKB/TrEMBL
    B3KTG9
    Related
    ENSP00000359121, OTTHUMP00000012614, ENST00000370103, OTTHUMT00000030144
    Conserved Domains (2) summary
    pfam12308
    Location:25125
    Noelin-1; Neurogenesis glycoprotein
    pfam02191
    Location:202450
    OLF; Olfactomedin-like domain

RNA

  1. NR_110210.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon structure and includes an alternate internal exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF397397, AK095551, DA528521, HY346025
  2. NR_110211.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' terminal exon and an alternate internal exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF397395, AK095551, DA528521, HY346025
  3. NR_110212.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate internal exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF397393, AK095551, AK300870, HY346025

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    101802567..101997234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270434.3XP_005270491.1  

    See identical proteins and their annotated locations for XP_005270491.1

    UniProtKB/Swiss-Prot
    Q96PB7
    Conserved Domains (2) summary
    pfam12308
    Location:150
    Noelin-1; Neurogenesis glycoprotein
    pfam02191
    Location:127375
    OLF; Olfactomedin-like domain

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    102383321..102578151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)