Format

Send to:

Choose Destination

Areg amphiregulin [ Mus musculus (house mouse) ]

Gene ID: 11839, updated on 8-May-2016
Official Symbol
Aregprovided by MGI
Official Full Name
amphiregulinprovided by MGI
Primary source
MGI:MGI:88068
See related
Ensembl:ENSMUSG00000029378 Vega:OTTMUSG00000055520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AR; Mcub; Sdgf
Summary
This gene encodes a member of the epidermal growth factor (EGF) family and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and has been shown to play a role in immunity, inflammation, tissue repair, and lung and mammary gland development. Homozygous knockout mice for this gene exhibit impaired immune system regulation in the skin and gene expression changes characteristic of chronic liver damage. [provided by RefSeq, Aug 2015]
Orthologs
Location:
5 E1; 5 44.78 cM
Exon count:
6
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (91139615..91148432)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (91568641..91577458)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102639958 Neighboring gene epithelial mitogen Neighboring gene epiregulin Neighboring gene predicted gene, 19619 Neighboring gene betacellulin, epidermal growth factor family member

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
epithelial cell proliferation involved in mammary gland duct elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
mammary gland alveolus development IGI
Inferred from Genetic Interaction
more info
PubMed 
mammary gland branching involved in thelarche IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
response to estradiol IDA
Inferred from Direct Assay
more info
PubMed 
response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
amphiregulin
Names
schwannoma-derived growth factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009704.4NP_033834.1  amphiregulin preproprotein

    See identical proteins and their annotated locations for NP_033834.1

    Status: REVIEWED

    Source sequence(s)
    AC115067, AK018590
    Consensus CDS
    CCDS19421.1
    UniProtKB/Swiss-Prot
    P31955
    UniProtKB/TrEMBL
    Q4FJT2
    Related
    ENSMUSP00000031325, OTTMUSP00000072375, ENSMUST00000031325, OTTMUST00000137420
    Conserved Domains (1) summary
    PHA02887
    Location:139179
    PHA02887; EGF-like protein; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    91139615..91148432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    89277608..89286422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)