App amyloid beta (A4) precursor protein [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Appprovided by MGI
Official Full Name: amyloid beta (A4) precursor proteinprovided by MGI
Primary source: MGI:88059
See related: Ensembl:ENSMUSG00000022892
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ag; Abpp; Adap; Cvap; Abeta; betaApp; E030013M08Rik

Genomic context

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Location :: 16 C3-qter; 16 46.92 cM

Sequence :: Chromosome: 16; NC_000082.6 (84954436..85173707, complement)

See App in Epigenomics, MapViewer

Chromosome 16 - NC_000082.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

an N-terminal fragment of the prion protein binds to amyloid-beta oligomers and inhibits their neurotoxicity in vivo
Title: An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo.
A peptide binding to the beta-site of APP improves spatial memory and attenuates Abeta burden in Alzheimer's disease transgenic mice
Title: A peptide binding to the β-site of APP improves spatial memory and attenuates Aβ burden in Alzheimer's disease transgenic mice.
Unique candidate genes were identified in adipose tissue and islets. In islets, the Alzheimer's gene App was identified as a top candidate regulator of plasma insulin secretion in response to glucose
Title: Integrative analysis of a cross-loci regulation network identifies App as a gene regulating insulin secretion from pancreatic islets.
Data indicate that plasma leptin negatively correlates with amyloid beta accumulation in brain via the gamma-secretase complex.
Title: Leptin regulates amyloid β production via the γ-secretase complex.
Mice carrying the Osaka mutation of APP exhibited reduced alpha-processing of APP and early accumulation of intraneuronal fibrillar Abeta oligomers associated with cognitive deficits.
Title: Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation.
Mutant amyloid precursor protein differentially alters adipose biology under obesogenic and non-obesogenic conditions.
Title: Mutant amyloid precursor protein differentially alters adipose biology under obesogenic and non-obesogenic conditions.
Despite the occurrence of abundant Alzheimer's disease mice models this review article is dedicated to selected models with mutations in the APP, MAPT and presenilin genes and their application for behavioral studies.
Title: [Selected mice models based on APP, MAPT and presenilin gene mutations in research on the pathogenesis of Alzheimer's disease].
apoE isoform-specific formation of soluble apoE/Abeta modulates oAbeta levels, suggesting a basis for APOE4-induced AD risk and a mechanistic approach to AD biomarkers
Title: Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples.
APP regulates cerebral blood flow in response to hypoxia
Title: APP knockout mice experience acute mortality as the result of ischemia.
a causal relationship between altered synaptic connectivity, cholinergic tone depression and TrkA signaling deficit, and cognitive and neuromuscular decline in APP(YG/YG) mice.
Title: Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance.

Submit: New GeneRIF Correction See all (412)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (2) 1 citation
Targeted (knock-out) (7) 1 citation
Targeted (other) (1) 1 citation
Targeted (knock-in) (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_031497.2	NP_034144.1	Dab1	BIND	PubMed	Dab1 interacts with APP.
NP_031497.2	NP_035292.2	Mapk8ip1	BIND	PubMed	JIP1b interacts with APP.
NP_031497.2	NP_068740.2	Mapk8ip2	BIND	PubMed	JIP2 interacts with APP.
NP_031497.2	NP_032630.2	Mme	BIND	PubMed	Mme interacts with Abeta40.
NP_031497.2	NP_032630.2	Mme	BIND	PubMed	Mme interacts with Abeta42.
BioGRID:198167	BioGRID:204741	Bace1	BioGRID	PubMed	Biochemical Activity
BioGRID:198167	BioGRID:198856	Cpeb1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198167	BioGRID:199228	Dlg1	BioGRID	PubMed	Co-localization
BioGRID:198167	BioGRID:222979	Gga1	BioGRID	PubMed	FRET
BioGRID:198167	BioGRID:200935	Kif1a	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198167	BioGRID:202389	Prnp	BioGRID	PubMed	Affinity Capture-MS
BioGRID:198167	BioGRID:203365	Snca	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198167	BioGRID:207969	Stub1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198167	BioGRID:204403	Ubc	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
Activated TLR4 signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Advanced glycosylation endproduct receptor signaling, organism-specific biosystem (from REACTOME)
Advanced glycosylation endproduct receptor signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Alzheimer's disease, organism-specific biosystem (from KEGG)
Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Alzheimer's disease, conserved biosystem (from KEGG)
Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Amyloids, organism-specific biosystem (from REACTOME)
Amyloids, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytosolic sensors of pathogen-associated DNA, organism-specific biosystem (from REACTOME)
Cytosolic sensors of pathogen-associated DNA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DAI mediated induction of type I IFNs, organism-specific biosystem (from REACTOME)
DAI mediated induction of type I IFNs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Formyl peptide receptors bind formyl peptides and many other ligands, organism-specific biosystem (from REACTOME)
Formyl peptide receptors bind formyl peptides and many other ligands, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
G alpha (q) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
MyD88 cascade initiated on plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
MyD88 dependent cascade initiated on endosome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88-independent cascade, organism-specific biosystem (from REACTOME)
MyD88-independent cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
Peptide ligand-binding receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet degranulation, organism-specific biosystem (from REACTOME)
Platelet degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RIP-mediated NFkB activation via DAI, organism-specific biosystem (from REACTOME)
RIP-mediated NFkB activation via DAI, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
Response to elevated platelet cytosolic Ca2+, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Serotonergic synapse, organism-specific biosystem (from KEGG)
Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystem (from REACTOME)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRAF6 mediated NF-kB activation, organism-specific biosystem (from REACTOME)
TRAF6 mediated NF-kB activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
Toll-Like Receptors Cascades, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

GDB:185158 (e-PCR)
- UniSTS:155414

RH124994 (e-PCR)
- UniSTS:161816

RH125538 (e-PCR)
- UniSTS:162353

App (e-PCR), detects polymorphism
- UniSTS:141114

App (e-PCR), detects polymorphism
- UniSTS:536418

App (e-PCR), detects polymorphism
- UniSTS:536419

App (e-PCR), detects polymorphism
- UniSTS:536420

RH139209 (e-PCR)
- UniSTS:221295

RH125986 (e-PCR)
- UniSTS:162698

APP (e-PCR)
- UniSTS:266418

App (e-PCR), detects polymorphism
- UniSTS:259038

NoName (e-PCR)
- UniSTS:237537

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
PTB domain binding	ISO Inferred from Sequence Orthology more info
acetylcholine receptor binding	ISO Inferred from Sequence Orthology more info
growth factor receptor binding	ISO Inferred from Sequence Orthology more info
heparin binding	IEA Inferred from Electronic Annotation more info
identical protein binding	ISO Inferred from Sequence Orthology more info
metal ion binding	IEA Inferred from Electronic Annotation more info
peptidase activator activity	ISO Inferred from Sequence Orthology more info
peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
receptor binding	ISO Inferred from Sequence Orthology more info
serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
transition metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Notch signaling pathway	IEA Inferred from Electronic Annotation more info
adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
apoptotic process	IEA Inferred from Electronic Annotation more info
axon cargo transport	IGI Inferred from Genetic Interaction more info
axon cargo transport	IMP Inferred from Mutant Phenotype more info	PubMed
NOT axon cargo transport	IMP Inferred from Mutant Phenotype more info	PubMed
axon midline choice point recognition	IMP Inferred from Mutant Phenotype more info	PubMed
axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
cell adhesion	IEA Inferred from Electronic Annotation more info
cellular copper ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
cellular copper ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
cholesterol metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
collateral sprouting in absence of injury	IGI Inferred from Genetic Interaction more info	PubMed
dendrite development	IGI Inferred from Genetic Interaction more info	PubMed
dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
extracellular matrix organization	IGI Inferred from Genetic Interaction more info	PubMed
forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
induction of apoptosis	ISO Inferred from Sequence Orthology more info
ionotropic glutamate receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
mRNA polyadenylation	IDA Inferred from Direct Assay more info	PubMed
mating behavior	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
neuromuscular process controlling balance	IGI Inferred from Genetic Interaction more info	PubMed
neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
neuron apoptotic process	ISO Inferred from Sequence Orthology more info
neuron projection development	IDA Inferred from Direct Assay more info	PubMed
neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of peptidase activity	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed
protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of epidermal growth factor-activated receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of protein binding	IGI Inferred from Genetic Interaction more info	PubMed
regulation of protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of synapse structure and activity	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of translation	IDA Inferred from Direct Assay more info	PubMed
response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
smooth endoplasmic reticulum calcium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
suckling behavior	IGI Inferred from Genetic Interaction more info	PubMed
synaptic growth at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
Golgi apparatus	ISO Inferred from Sequence Orthology more info
apical part of cell	IDA Inferred from Direct Assay more info	PubMed
axon	IDA Inferred from Direct Assay more info	PubMed
cell surface	ISO Inferred from Sequence Orthology more info
ciliary rootlet	IDA Inferred from Direct Assay more info	PubMed
coated pit	IEA Inferred from Electronic Annotation more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IDA Inferred from Direct Assay more info	PubMed
intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
membrane	IDA Inferred from Direct Assay more info	PubMed
membrane	TAS Traceable Author Statement more info	PubMed
neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
neuron projection	IDA Inferred from Direct Assay more info	PubMed
neuron projection	ISO Inferred from Sequence Orthology more info
perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	ISO Inferred from Sequence Orthology more info
spindle midzone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: amyloid beta A4 protein

Names: amyloid beta A4 protein; appican; protease nexin II; amyloidogenic glycoprotein; alzheimer disease amyloid A4 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198823.1 → NP_001185752.1 amyloid beta A4 protein isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK128971, AK159718, BC070409, BP753972

UniProtKB/Swiss-Prot

P12023

UniProtKB/TrEMBL

Q3TWF3

UniProtKB/TrEMBL

Q6GR78

Conserved Domains (8) summary

cd00109
Location:291 – 342
Blast Score: 222

KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

pfam03494
Location:682 – 705
Blast Score: 112

Beta-APP; Beta-amyloid peptide (beta-APP)

smart00006
Location:24 – 188
Blast Score: 824

A4_EXTRA; amyloid A4

pfam10515
Location:724 – 766
Blast Score: 220

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam02177
Location:30 – 131
Blast Score: 489

APP_N; Amyloid A4 N-terminal heparin-binding

pfam12924
Location:132 – 188
Blast Score: 302

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam11740
Location:407 – 474
Blast Score: 85

KfrA_N; Plasmid replication region DNA-binding N-term

pfam12925
Location:365 – 549
Blast Score: 733

APP_E2; E2 domain of amyloid precursor protein
NM_001198824.1 → NP_001185753.1 amyloid beta A4 protein isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK128971, AK133639, BC070409, BP753972

UniProtKB/TrEMBL

Q6GR78

Conserved Domains (8) summary

cd00109
Location:291 – 342
Blast Score: 221

KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

pfam03494
Location:663 – 686
Blast Score: 111

Beta-APP; Beta-amyloid peptide (beta-APP)

smart00006
Location:24 – 188
Blast Score: 822

A4_EXTRA; amyloid A4

pfam10515
Location:705 – 747
Blast Score: 220

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam02177
Location:30 – 131
Blast Score: 488

APP_N; Amyloid A4 N-terminal heparin-binding

pfam12924
Location:132 – 188
Blast Score: 300

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam11740
Location:388 – 455
Blast Score: 85

KfrA_N; Plasmid replication region DNA-binding N-term

pfam12925
Location:346 – 530
Blast Score: 735

APP_E2; E2 domain of amyloid precursor protein
NM_001198825.1 → NP_001185754.1 amyloid beta A4 protein isoform 5 precursor

Status: VALIDATED

Description

Transcript Variant: Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK128971, AK133639, BC070409, BP753972

UniProtKB/TrEMBL

Q6GR78

Conserved Domains (8) summary

cd00109
Location:291 – 342
Blast Score: 219

KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

pfam03494
Location:645 – 668
Blast Score: 111

Beta-APP; Beta-amyloid peptide (beta-APP)

smart00006
Location:24 – 188
Blast Score: 821

A4_EXTRA; amyloid A4

pfam10515
Location:687 – 729
Blast Score: 220

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam02177
Location:30 – 131
Blast Score: 487

APP_N; Amyloid A4 N-terminal heparin-binding

pfam12924
Location:132 – 188
Blast Score: 299

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam11740
Location:388 – 455
Blast Score: 86

KfrA_N; Plasmid replication region DNA-binding N-term

pfam12925
Location:346 – 530
Blast Score: 735

APP_E2; E2 domain of amyloid precursor protein
NM_001198826.1 → NP_001185755.1 amyloid beta A4 protein isoform 6 precursor

Status: VALIDATED

Description

Transcript Variant: Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK128971, AK159718, BC070409, BP753972

UniProtKB/TrEMBL

Q3TWF3

UniProtKB/TrEMBL

Q6GR78

Conserved Domains (8) summary

cd00109
Location:291 – 342
Blast Score: 221

KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

pfam03494
Location:664 – 687
Blast Score: 112

Beta-APP; Beta-amyloid peptide (beta-APP)

smart00006
Location:24 – 188
Blast Score: 822

A4_EXTRA; amyloid A4

pfam10515
Location:706 – 748
Blast Score: 220

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam02177
Location:30 – 131
Blast Score: 488

APP_N; Amyloid A4 N-terminal heparin-binding

pfam12924
Location:132 – 188
Blast Score: 301

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam11740
Location:407 – 474
Blast Score: 86

KfrA_N; Plasmid replication region DNA-binding N-term

pfam12925
Location:365 – 549
Blast Score: 733

APP_E2; E2 domain of amyloid precursor protein
NM_007471.3 → NP_031497.2 amyloid beta A4 protein isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK128971, BC070409, BP753972

Consensus CDS

CCDS28285.1

UniProtKB/TrEMBL

Q6GR78

Related

ENSMUSP00000005406, ENSMUST00000005406

Conserved Domains (6) summary

pfam03494
Location:607 – 630
Blast Score: 110

Beta-APP; Beta-amyloid peptide (beta-APP)

smart00006
Location:24 – 188
Blast Score: 832

A4_EXTRA; amyloid A4

pfam10515
Location:649 – 691
Blast Score: 217

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam02177
Location:30 – 131
Blast Score: 493

APP_N; Amyloid A4 N-terminal heparin-binding

pfam12924
Location:132 – 188
Blast Score: 307

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam12925
Location:294 – 474
Blast Score: 705

APP_E2; E2 domain of amyloid precursor protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000082.6 Reference GRCm38.p1 C57BL/6J

Range

84954436..85173707, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000038.1 Alternate Mm_Celera

Range

85161859..85329235, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01129727.1 (15102..62060)	None
genomic	AAHY01129728.1	None
genomic	AAHY01129729.1	None
genomic	AAHY01129730.1	None
genomic	AAHY01129731.1	None
genomic	AAHY01129732.1 (1708..17201)	None
genomic	AC164302.2 (70466..177335)	None
genomic	AF056079.1	AAC63987.1	BALB/c
genomic	AY011334.1	AAG47369.1
genomic	CH466521.1	EDK98318.1	mixed
		EDK98319.1	mixed
genomic	CS448148.1	CAL69793.1
genomic	CS448170.1	CAL69797.1
genomic	CT010505.18 (96146..229346)	None
genomic	D10603.1	BAA01456.1	BALB/c
genomic	U82624.1	AAB40919.1	129/Sv
mRNA	AK029172.1	None	C57BL/6J
mRNA	AK030583.1	None	C57BL/6J
mRNA	AK052448.1	BAC34997.1	C57BL/6J
mRNA	AK076506.1	BAC36369.1	C57BL/6J
mRNA	AK086946.1	None	C57BL/6J
mRNA	AK128971.1	None
mRNA	AK133639.1	None	C57BL/6J
mRNA	AK147543.1	BAE27986.1	C57BL/6J
mRNA	AK148439.1	None	C57BL/6J
mRNA	AK159245.1	BAE34927.1	C57BL/6J
mRNA	AK159352.1	None	C57BL/6J
mRNA	AK159718.1	BAE35313.1	C57BL/6J
mRNA	AK161854.1	None	C57BL/6J
mRNA	AK161976.1	None	C57BL/6J
mRNA	AK190051.1	None
mRNA	AK190067.1	None
mRNA	AK190928.1	None
mRNA	AK191703.1	None
mRNA	AK191711.1	None
mRNA	AK192103.1	None
mRNA	AK192320.1	None
mRNA	AK192899.1	None
mRNA	AK192938.1	None
mRNA	AK194233.1	None
mRNA	AK194558.1	None
mRNA	AK194593.1	None
mRNA	AK194656.1	None
mRNA	AK197763.1	None
mRNA	AK198568.1	None
mRNA	AK199923.1	None
mRNA	AK200287.1	None
mRNA	AK200960.1	None
mRNA	AK201130.1	None
mRNA	AK202486.1	None
mRNA	AK202618.1	None
mRNA	AK203089.1	None
mRNA	AK208786.1	None
mRNA	AK209458.1	None
mRNA	AK210249.1	None
mRNA	AK211859.1	None
mRNA	AK213784.1	None
mRNA	AK216049.1	None
mRNA	AK216591.1	None
mRNA	AK218128.1	None
mRNA	AK218334.1	None
mRNA	AY267348.1	AAP23169.1	C57BL/6
mRNA	BC005490.1	AAH05490.1
mRNA	BC070409.1	AAH70409.1	C57BL/6
mRNA	BP753972.1	None	C57BL/6
mRNA	M18373.1	AAA37139.1
mRNA	M24397.1	AAA39929.1
mRNA	U84012.1	AAB41502.1	SAMP8
mRNA	X15210.1	CAA33280.1	CD-1
mRNA	X59379.1	None	BALB/c