Birc5 baculoviral IAP repeat-containing 5 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Birc5provided by MGI
Official Full Name: baculoviral IAP repeat-containing 5provided by MGI
Primary source: MGI:1203517
Locus tag: RP23-268N22.2
See related: Ensembl:ENSMUSG00000017716; Vega:OTTMUSG00000003737
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Api4; TIAP; AAC-11; survivin40
Summary: This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 11; 11 E2

Sequence :: Chromosome: 11; NC_000077.6 (117849237..117855743)

See Birc5 in Epigenomics, MapViewer

Chromosome 11 - NC_000077.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Survivin is a dual regulator of lens epithelial cell proliferation and lens fiber cell differentiation.
Title: Survivin expression is associated with lens epithelial cell proliferation and fiber cell differentiation.
A novel Sox2/survivin pathway that regulates neural stem cells survival and homoeostasis, thus revealing a new mechanism of brain development, neurological degeneration and such aging-related disorders.
Title: Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression.
Expression of survivin is a downstream event of Flt3 signaling.
Title: Activation of Fms-like tyrosine kinase 3 signaling enhances survivin expression in a mouse model of rheumatoid arthritis.
survivin is essential for beta-cell mass expansion after PDL. Survivin appears to exhibit a preferential requirement for proliferation of preexisting beta cells.
Title: Survivin is required for beta-cell mass expansion in the pancreatic duct-ligated mouse model.
Surv(-/-) mice exhibit severe global conduction attenuations in atrial and ventricular myocardium as well as the specific conduction system, accompanied by lower connexin43 levels.
Title: Cardiomyocyte-specific deletion of survivin causes global cardiac conduction defects.
Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin.
Title: Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin.
UV-B induces cytoplasmic survivin expression in mouse epidermis
Title: UV-B induces cytoplasmic survivin expression in mouse epidermis.
Data show that tea polyphenols possibly downregulates the expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB), cyclooxygenase-2 (COX-2) and Survivin in tumor tissue, thereby playing important roles in anti-angiogenesis.
Title: [Effects of tea polyphenols on the expression of NF-κB, COX-2 and survivin in Lewis lung carcinoma xenografts in C57BL/6 mice].
HDAC6 deacetylates survivin to regulate its nuclear export
Title: Histone deacetylase 6 (HDAC6) deacetylates survivin for its nuclear export in breast cancer.
these results showed that the localization of Plk1 to kinetochores required the involvement of Survivin.
Title: Survivin regulates Plk1 localization to kinetochore in mouse oocyte meiosis.

Submit: New GeneRIF Correction See all (76)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (2) 1 citation
Targeted (knock-out) (1) 1 citation
Targeted (Reporter) (1) 1 citation
Gene trapped (1)

Pathways from BioSystems

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Apoptosis, organism-specific biosystem (from WikiPathways)
Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Colorectal cancer, organism-specific biosystem (from KEGG)
Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
Colorectal cancer, conserved biosystem (from KEGG)
Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
Hepatitis B, organism-specific biosystem (from KEGG)
Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
Hippo signaling pathway, organism-specific biosystem (from KEGG)
Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
Hippo signaling pathway, conserved biosystem (from KEGG)
Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
M Phase, organism-specific biosystem (from REACTOME)
M Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Mitotic Anaphase, organism-specific biosystem (from REACTOME)
Mitotic Anaphase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
Mitotic Metaphase and Anaphase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
Mitotic Prometaphase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
Resolution of Sister Chromatid Cohesion, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
Separation of Sister Chromatids, organism-specific biosystemcomputationally inferred pathway (not manually curated)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

General gene information

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Markers

Birc5 (e-PCR), detects polymorphism
- UniSTS:506752

Homology

Homologs of the Birc5 gene: The Birc5 gene is conserved in human, Rhesus monkey, dog, cow, chicken, zebrafish, and fruit fly.
Map Viewer (Human)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
Ran GTPase binding	ISO Inferred from Sequence Orthology more info
chaperone binding	ISO Inferred from Sequence Orthology more info
cofactor binding	ISO Inferred from Sequence Orthology more info
cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enzyme binding	ISO Inferred from Sequence Orthology more info
identical protein binding	ISO Inferred from Sequence Orthology more info
metal ion binding	IEA Inferred from Electronic Annotation more info
microtubule binding	ISO Inferred from Sequence Orthology more info
peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
protein homodimerization activity	ISO Inferred from Sequence Orthology more info
tubulin binding	ISO Inferred from Sequence Orthology more info
zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
apoptotic process	IEA Inferred from Electronic Annotation more info
cell cycle	IEA Inferred from Electronic Annotation more info
cell division	ISO Inferred from Sequence Orthology more info
chromosome segregation	IEA Inferred from Electronic Annotation more info
cytokinesis	ISO Inferred from Sequence Orthology more info
embryo development	IMP Inferred from Mutant Phenotype more info	PubMed
establishment of chromosome localization	ISO Inferred from Sequence Orthology more info
microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
mitosis	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of apoptotic process	RCA inferred from Reviewed Computational Analysis more info	PubMed
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
negative regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
positive regulation of exit from mitosis	ISO Inferred from Sequence Orthology more info
positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
protein complex localization	ISO Inferred from Sequence Orthology more info
protein phosphorylation	ISO Inferred from Sequence Orthology more info
regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
spindle checkpoint	ISO Inferred from Sequence Orthology more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
apical plasma membrane	ISO Inferred from Sequence Orthology more info
centriole	ISO Inferred from Sequence Orthology more info
chromosome	IEA Inferred from Electronic Annotation more info
chromosome passenger complex	ISO Inferred from Sequence Orthology more info
chromosome, centromeric region	ISO Inferred from Sequence Orthology more info	PubMed
condensed chromosome kinetochore	ISO Inferred from Sequence Orthology more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	ISO Inferred from Sequence Orthology more info
interphase microtubule organizing center	ISO Inferred from Sequence Orthology more info
kinetochore	IEA Inferred from Electronic Annotation more info
microtubule	IEA Inferred from Electronic Annotation more info
midbody	ISO Inferred from Sequence Orthology more info	PubMed
nuclear chromosome	ISO Inferred from Sequence Orthology more info
nucleus	ISO Inferred from Sequence Orthology more info
spindle microtubule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: baculoviral IAP repeat-containing protein 5

Names: baculoviral IAP repeat-containing protein 5; survivin; apoptosis inhibitor 4; apoptosis inhibitor survivin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012273.1 → NP_001012273.1 baculoviral IAP repeat-containing protein 5 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3), also known as survivin121, uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform 3 which has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AB013819, BC004702, BY023910

Consensus CDS

CCDS25695.1

UniProtKB/Swiss-Prot

O70201

Related

ENSMUSP00000091433, OTTMUSP00000003967, ENSMUST00000093906, OTTMUST00000008141

Conserved Domains (1) summary

cd00022
Location:18 – 87
Blast Score: 209

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
NM_009689.2 → NP_033819.1 baculoviral IAP repeat-containing protein 5 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1), also known as survivin140, represents the most frequently occurring transcript and it encodes isoform 1.

Source sequence(s)

AB013819, AI413910, CN724527

Consensus CDS

CCDS25694.1

UniProtKB/Swiss-Prot

O70201

UniProtKB/TrEMBL

Q549P2

Related

ENSMUSP00000079124, OTTMUSP00000003966, ENSMUST00000081387, OTTMUST00000008140

Conserved Domains (1) summary

cd00022
Location:18 – 87
Blast Score: 216

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000077.6 Reference GRCm38.p1 C57BL/6J

Range

117849237..117855743

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000033.1 Alternate Mm_Celera

Range

129594259..129600765

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001012272.1: Suppressed sequence

Description

NM_001012272.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01096841.1 (61126..67632)	None
genomic	AB036741.1	BAB19787.1	129/Sv
genomic	AF077351.1	AAG41214.1	C57BL/6
genomic	AF115517.1	AAD26199.1
		AAD26200.1
		AAD26201.1
genomic	AL591433.6 (25579..32085)	None
genomic	CH466558.1	EDL34641.1	mixed
		EDL34642.1	mixed
genomic	HD050397.1	CBV35667.1
mRNA	AB013819.1	BAA28266.1
mRNA	AF077349.1	AAD34225.1
mRNA	AI413910.1	None	C57BL/6J
mRNA	AK018022.1	None	C57BL/6J
mRNA	AK038229.1	None	C57BL/6J
mRNA	AK142768.1	BAE25189.1	C57BL/6J
mRNA	BC004702.1	AAH04702.1	FVB/N
mRNA	BY023910.1	None
mRNA	CN724527.1	None	C57BL/6J
mRNA	EU366955.1	ABY66389.1	C57BL/6