Atg5 autophagy related 5 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Atg5provided by MGI
Official Full Name: autophagy related 5provided by MGI
Primary source: MGI:1277186
See related: Ensembl:ENSMUSG00000038160
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Apg5l; Atg5l; Paddy; C88337; AW319544; 2010107M05Rik; 3110067M24Rik

Genomic context

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Location :: 10 B2; 10 23.24 cM

Sequence :: Chromosome: 10; NC_000076.6 (44268358..44364291)

See Atg5 in Epigenomics, MapViewer

Chromosome 10 - NC_000076.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Knockdown of ATG5 and beclin 1 blocked clinical grade IL-2-induced autophagy.
Title: Autophagy is required for IL-2-mediated fibroblast growth.
Persistent activation of Nrf2 and increased hepatocyte proliferation protect against acetominophen-induced liver injury in Atg5 liver-specific knockout mice.
Title: Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.
Atg5-Atg12/Atg16L1 protein complex is required for IFNgamma-mediated host defense against murine norovirus infection.
Title: Nondegradative role of Atg5-Atg12/ Atg16L1 autophagy protein complex in antiviral activity of interferon gamma.
These results reveal new roles for autophagy-related molecules Atg5 and Ambra1 during early neuronal differentiation of stem/progenitor cells.
Title: Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells.
Despite forming the Atg12-Atg5-Atg16L2 complex, Atg16L2 is not recruited to phagophores and is mostly present in the cytosol.
Title: Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex.
ULK1 negatively regulates the kinase activity of mTORC1 and cell proliferation in a manner independent of Atg5 and TSC2
Title: ULK1 inhibits the kinase activity of mTORC1 and cell proliferation.
The Atg5 participates in polarized secretion of lysosomal contents into the extracellular space by directing lysosomes to fuse with the plasma membrane.
Title: Autophagy proteins regulate the secretory component of osteoclastic bone resorption.
The essential autophagy genes Atg5 leads to the accumulation of all detectable Ub-Ub topologies, arguing against the hypothesis that any particular Ub linkage serves as a specific autophagy signal.
Title: Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection.
Inactivating Atg5 in Sindbis virus-infected neurons results in delayed clearance of viral proteins, increased accumulation of the cellular p62 adaptor protein, and increased cell death in neurons, but the levels of viral replication remain unaltered.
Title: Autophagy protects against Sindbis virus infection of the central nervous system.
Autophagy participated the process of immune response of anti-MTB. Atg5 were the important molecule which control the formation of autophagy when MTB infected.
Title: [Effect of autophagy in MTB's infection and the expression of its related gene].

Submit: New GeneRIF Correction See all (30)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (1) 1 citation
Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:198146	BioGRID:212249	Atg12	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:198146	BioGRID:218476	Atg16l1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-localization
BioGRID:198146	BioGRID:198500	Casp8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198146	BioGRID:199586	Fadd	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198146	BioGRID:202543	Rab33b	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem (from REACTOME)
Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of autophagy, organism-specific biosystem (from KEGG)
Regulation of autophagy, organism-specific biosystem
Regulation of autophagy
Regulation of autophagy, conserved biosystem (from KEGG)
Regulation of autophagy, conserved biosystem
Regulation of autophagy
Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

General gene information

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Markers

AW319544 (e-PCR)
- UniSTS:180036

Atg5 (e-PCR), detects polymorphism
- UniSTS:526933

C88337 (e-PCR)
- UniSTS:208512

Homology

Homologs of the Atg5 gene: The Atg5 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, and rice.
Map Viewer (Human)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
autophagic vacuole assembly	IMP Inferred from Mutant Phenotype more info	PubMed
autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
otolith development	IMP Inferred from Mutant Phenotype more info
post-translational protein modification	IDA Inferred from Direct Assay more info	PubMed
regulation of cytokine secretion involved in immune response	IMP Inferred from Mutant Phenotype more info
response to drug	IMP Inferred from Mutant Phenotype more info	PubMed
response to fungus	IMP Inferred from Mutant Phenotype more info
vasodilation	IMP Inferred from Mutant Phenotype more info	PubMed
ventricular cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
autophagic vacuole	IDA Inferred from Direct Assay more info	PubMed
autophagic vacuole	ISA Inferred from Sequence Alignment more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
pre-autophagosomal structure membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: autophagy protein 5

Names: autophagy protein 5; autophagy-related 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053069.5 → NP_444299.1 autophagy protein 5

Status: PROVISIONAL

Source sequence(s)

AC155642

Consensus CDS

CCDS23824.1

UniProtKB/Swiss-Prot

Q99J83

Related

ENSMUSP00000044769, ENSMUST00000039286

Conserved Domains (1) summary

pfam04106
Location:79 – 271
Blast Score: 661

APG5; Autophagy protein Apg5

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000076.6 Reference GRCm38.p1 C57BL/6J

Range

44268358..44364291

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000032.1 Alternate Mm_Celera

Range

45141131..45237099

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01085156.1 (17505..23444)	None
genomic	AAHY01085157.1	None
genomic	AAHY01085158.1	None
genomic	AAHY01085159.1	None
genomic	AAHY01085160.1	None
genomic	AAHY01085161.1	None
genomic	AAHY01085162.1	None
genomic	AAHY01085163.1	None
genomic	AC155642.6 (92995..188929)	None
genomic	CH466540.1	EDL05030.1	mixed
mRNA	AB048349.1	BAB33383.1
mRNA	AK008351.1	BAC25216.1	C57BL/6J
mRNA	AK028315.1	BAC25874.1	C57BL/6J
mRNA	AK207331.1	None
mRNA	BC002166.1	AAH02166.1