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Apc adenomatosis polyposis coli [ Mus musculus (house mouse) ]

Gene ID: 11789, updated on 17-May-2016
Official Symbol
Apcprovided by MGI
Official Full Name
adenomatosis polyposis coliprovided by MGI
Primary source
MGI:MGI:88039
See related
Ensembl:ENSMUSG00000005871
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CC1; Min; mAPC; AI047805; AU020952; AW124434
Orthologs
Location:
18 B1; 18 18.53 cM
Exon count:
19
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 18 NC_000084.6 (34220307..34322190)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (34380638..34481844)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41687 Neighboring gene predicted gene, 41686 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene predicted gene, 41685 Neighboring gene signal recognition particle 19 Neighboring gene receptor accessory protein 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
gamma-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
gamma-catenin binding ISO
Inferred from Sequence Orthology
more info
 
microtubule binding ISO
Inferred from Sequence Orthology
more info
 
microtubule plus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule plus-end binding ISO
Inferred from Sequence Orthology
more info
 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway involved in negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
canonical Wnt signaling pathway involved in positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
chromosome organization IGI
Inferred from Genetic Interaction
more info
PubMed 
chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasmic microtubule organization IGI
Inferred from Genetic Interaction
more info
PubMed 
dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment or maintenance of cell polarity ISO
Inferred from Sequence Orthology
more info
 
hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
metaphase/anaphase transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
metaphase/anaphase transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
mitotic spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
 
muscle cell cellular homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial cell proliferation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of odontogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection development ISO
Inferred from Sequence Orthology
more info
 
pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pseudopodium assembly ISO
Inferred from Sequence Orthology
more info
 
protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of glutamate metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of microtubule-based process ISO
Inferred from Sequence Orthology
more info
 
regulation of nitrogen compound metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatic stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Scrib-APC-beta-catenin complex IDA
Inferred from Direct Assay
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
axonal growth cone IDA
Inferred from Direct Assay
more info
PubMed 
axonal growth cone ISO
Inferred from Sequence Orthology
more info
 
beta-catenin destruction complex IBA
Inferred from Biological aspect of Ancestor
more info
 
beta-catenin destruction complex ISO
Inferred from Sequence Orthology
more info
 
bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
catenin complex ISO
Inferred from Sequence Orthology
more info
 
cell body fiber ISO
Inferred from Sequence Orthology
more info
 
cell cortex ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IDA
Inferred from Direct Assay
more info
PubMed 
cell projection membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cell-cell adherens junction ISO
Inferred from Sequence Orthology
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
growth cone ISO
Inferred from Sequence Orthology
more info
 
kinetochore ISO
Inferred from Sequence Orthology
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
microtubule ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with microtubule plus-end IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuron projection terminus ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
ruffle membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with synapse ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
adenomatous polyposis coli protein
Names
multiple intestinal neoplasia

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007462.3NP_031488.2  adenomatous polyposis coli protein

    See identical proteins and their annotated locations for NP_031488.2

    Status: VALIDATED

    Source sequence(s)
    AC090534, AK080907, AL591373, BE623286
    Consensus CDS
    CCDS29125.1
    UniProtKB/TrEMBL
    B2RUG9, Q8BNP7
    Related
    ENSMUSP00000078337, OTTMUSP00000051004, ENSMUST00000079362, OTTMUST00000092329
    Conserved Domains (6) summary
    pfam05937
    Location:26702842
    EB1_binding; EB-1 Binding Domain
    pfam05923
    Location:16341659
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:20332052
    SAMP; SAMP Motif
    pfam11414
    Location:124206
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    cd00020
    Location:609729
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05956
    Location:22232568
    APC_basic; APC basic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p3 C57BL/6J

    Range
    34220307..34322190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525529.2XP_006525592.1  

    Conserved Domains (6) summary
    pfam05937
    Location:26982870
    EB1_binding; EB-1 Binding Domain
    pfam05923
    Location:16621687
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:20612080
    SAMP; SAMP Motif
    pfam11414
    Location:134216
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    cd00020
    Location:637757
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05956
    Location:22512596
    APC_basic; APC basic domain
  2. XM_006525534.2XP_006525597.1  

    Conserved Domains (6) summary
    pfam05937
    Location:26632835
    EB1_binding; EB-1 Binding Domain
    pfam05923
    Location:16271652
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:20262045
    SAMP; SAMP Motif
    pfam11414
    Location:134216
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    cd00020
    Location:602722
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05956
    Location:22162561
    APC_basic; APC basic domain
  3. XM_006525532.2XP_006525595.1  

    See identical proteins and their annotated locations for XP_006525595.1

    Conserved Domains (6) summary
    pfam05937
    Location:26802852
    EB1_binding; EB-1 Binding Domain
    pfam05923
    Location:16441669
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:20432062
    SAMP; SAMP Motif
    pfam11414
    Location:134216
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    cd00020
    Location:619739
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05956
    Location:22332578
    APC_basic; APC basic domain
  4. XM_006525538.2XP_006525601.1  

    Conserved Domains (6) summary
    pfam05937
    Location:25972769
    EB1_binding; EB-1 Binding Domain
    pfam05923
    Location:15611586
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:19601979
    SAMP; SAMP Motif
    pfam11414
    Location:134216
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    cd00020
    Location:536656
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05956
    Location:21502495
    APC_basic; APC basic domain
  5. XM_006525530.1XP_006525593.1  

    See identical proteins and their annotated locations for XP_006525593.1

    Conserved Domains (6) summary
    pfam05937
    Location:26882860
    EB1_binding; EB-1 Binding Domain
    pfam05923
    Location:16521677
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:20512070
    SAMP; SAMP Motif
    pfam11414
    Location:124206
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    cd00020
    Location:627747
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05956
    Location:22412586
    APC_basic; APC basic domain
  6. XM_006525539.1XP_006525602.1  

    Conserved Domains (6) summary
    pfam05937
    Location:25692741
    EB1_binding; EB-1 Binding Domain
    pfam05923
    Location:15331558
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:19321951
    SAMP; SAMP Motif
    pfam11414
    Location:124206
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    cd00020
    Location:508628
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05956
    Location:21222467
    APC_basic; APC basic domain
  7. XM_006525533.2XP_006525596.1  

    Conserved Domains (6) summary
    pfam05937
    Location:26682840
    EB1_binding; EB-1 Binding Domain
    pfam05923
    Location:16321657
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:20312050
    SAMP; SAMP Motif
    pfam11414
    Location:104186
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    cd00020
    Location:607727
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05956
    Location:22212566
    APC_basic; APC basic domain
  8. XM_006525531.1XP_006525594.1  

    See identical proteins and their annotated locations for XP_006525594.1

    Conserved Domains (6) summary
    pfam05937
    Location:26882860
    EB1_binding; EB-1 Binding Domain
    pfam05923
    Location:16521677
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:20512070
    SAMP; SAMP Motif
    pfam11414
    Location:124206
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    cd00020
    Location:627747
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05956
    Location:22412586
    APC_basic; APC basic domain
  9. XM_006525536.2XP_006525599.1  

    See identical proteins and their annotated locations for XP_006525599.1

    Conserved Domains (6) summary
    pfam05937
    Location:26292801
    EB1_binding; EB-1 Binding Domain
    pfam05923
    Location:15931618
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:19922011
    SAMP; SAMP Motif
    pfam11414
    Location:65147
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    cd00020
    Location:568688
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05956
    Location:21822527
    APC_basic; APC basic domain
  10. XM_006525535.1XP_006525598.1  

    See identical proteins and their annotated locations for XP_006525598.1

    Conserved Domains (6) summary
    pfam05937
    Location:26292801
    EB1_binding; EB-1 Binding Domain
    pfam05923
    Location:15931618
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:19922011
    SAMP; SAMP Motif
    pfam11414
    Location:65147
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    cd00020
    Location:568688
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05956
    Location:21822527
    APC_basic; APC basic domain

Alternate Mm_Celera

Genomic

  1. AC_000040.1 Alternate Mm_Celera

    Range
    34670234..34773431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)