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Apbb2 amyloid beta (A4) precursor protein-binding, family B, member 2 [ Mus musculus (house mouse) ]

Gene ID: 11787, updated on 8-May-2016
Official Symbol
Apbb2provided by MGI
Official Full Name
amyloid beta (A4) precursor protein-binding, family B, member 2provided by MGI
Primary source
MGI:MGI:108405
See related
Ensembl:ENSMUSG00000029207 Vega:OTTMUSG00000033024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TR2L; Zfra; Rirl1; FE65L1; 2310007D03Rik
Orthologs
Location:
5; 5 C3.1
Exon count:
20
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (66298725..66618817, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (66693127..67009910, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102635521 Neighboring gene RIKEN cDNA 1700126H18 gene Neighboring gene predicted gene, 40311 Neighboring gene predicted gene 15794 Neighboring gene NOL1/NOP2/Sun domain family, member 7 Neighboring gene predicted gene, 32964 Neighboring gene ubiquitin carboxy-terminal hydrolase L1, opposite strand Neighboring gene predicted gene, 40313 Neighboring gene ubiquitin carboxy-terminal hydrolase L1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
beta-amyloid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
histone acetyltransferase binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
actin filament-based movement NAS
Non-traceable Author Statement
more info
PubMed 
axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix organization IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization NAS
Non-traceable Author Statement
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
amyloid beta A4 precursor protein-binding family B member 2
Names
zinc finger-like protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201413.1NP_001188342.1  amyloid beta A4 precursor protein-binding family B member 2 isoform 2

    See identical proteins and their annotated locations for NP_001188342.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC131752, AK167649, BY333882
    Consensus CDS
    CCDS57345.1
    UniProtKB/TrEMBL
    Q3TIZ5
    Related
    ENSMUSP00000123978, OTTMUSP00000044160, ENSMUST00000160870, OTTMUST00000082397
    Conserved Domains (3) summary
    cd00201
    Location:293321
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd01271
    Location:582708
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:416553
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
  2. NM_001201414.1NP_001188343.1  amyloid beta A4 precursor protein-binding family B member 2 isoform 3

    See identical proteins and their annotated locations for NP_001188343.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC131752, AK032770, AK153260, BC076587, BY333882
    Consensus CDS
    CCDS57346.1
    UniProtKB/Swiss-Prot
    Q9DBR4
    UniProtKB/TrEMBL
    E9PWH3, Q3U674, Q8BSK4
    Related
    ENSMUSP00000124807, OTTMUSP00000044165, ENSMUST00000159512, OTTMUST00000082405
    Conserved Domains (3) summary
    cd00201
    Location:294322
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd01271
    Location:562688
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:396533
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
  3. NM_001201415.1NP_001188344.1  amyloid beta A4 precursor protein-binding family B member 2 isoform 4

    See identical proteins and their annotated locations for NP_001188344.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two in-frame exons compared to variant 1. The resulting isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC131752, BC076587, BY333882
    Consensus CDS
    CCDS57344.1
    UniProtKB/Swiss-Prot
    Q9DBR4
    Related
    ENSMUSP00000125211, OTTMUSP00000044166, ENSMUST00000159786, OTTMUST00000082408
    Conserved Domains (3) summary
    cd00201
    Location:293321
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd01271
    Location:561687
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:395532
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
  4. NM_001201416.1NP_001188345.1  amyloid beta A4 precursor protein-binding family B member 2 isoform 5

    See identical proteins and their annotated locations for NP_001188345.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks multiple coding exons from the 5' end and has an alternate 5' exon compared to variant 1. It initiates translation at a downstream start codon. The resulting isoform (5) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC131752
    UniProtKB/TrEMBL
    Q3T9N0
    Conserved Domains (1) summary
    cd01271
    Location:34160
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
  5. NM_001310626.1NP_001297555.1  amyloid beta A4 precursor protein-binding family B member 2 isoform 6

    See identical proteins and their annotated locations for NP_001297555.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two in-frame exons and uses an alternate in-frame splice site compared to variant 1. The resulting isoform (6) is shorter than isoform 1.
    Source sequence(s)
    AC123049, AC131752, AC149587, AC165426
    Consensus CDS
    CCDS80292.1
    UniProtKB/TrEMBL
    Q3TDW6
    Conserved Domains (3) summary
    cd00201
    Location:293321
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd01271
    Location:560686
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:395532
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
  6. NM_009686.2NP_033816.1  amyloid beta A4 precursor protein-binding family B member 2 isoform 1

    See identical proteins and their annotated locations for NP_033816.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC131752, AK004792, BY333882
    Consensus CDS
    CCDS51510.1
    UniProtKB/Swiss-Prot
    Q9DBR4
    UniProtKB/TrEMBL
    F6V9I9
    Related
    ENSMUSP00000123752, OTTMUSP00000072603, ENSMUST00000162349, OTTMUST00000137968
    Conserved Domains (3) summary
    cd00201
    Location:293321
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd01271
    Location:584710
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:416555
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    66298725..66618817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503696.2XP_006503759.1  

    See identical proteins and their annotated locations for XP_006503759.1

    UniProtKB/TrEMBL
    Q3T9N0
    Conserved Domains (1) summary
    cd01271
    Location:34160
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
  2. XM_006503697.2XP_006503760.1  

    See identical proteins and their annotated locations for XP_006503760.1

    UniProtKB/TrEMBL
    Q3T9N0
    Conserved Domains (1) summary
    cd01271
    Location:34160
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
  3. XM_006503694.2XP_006503757.1  

    See identical proteins and their annotated locations for XP_006503757.1

    UniProtKB/TrEMBL
    E9PWH3
    Conserved Domains (3) summary
    cd00201
    Location:294322
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd01271
    Location:562688
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:396533
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
  4. XM_006503695.2XP_006503758.1  

    Related
    ENSMUSP00000125116, OTTMUSP00000044167, ENSMUST00000162366, OTTMUST00000082409
    Conserved Domains (3) summary
    cd00201
    Location:293321
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd01271
    Location:560686
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:395532
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
  5. XM_006503690.2XP_006503753.1  

    See identical proteins and their annotated locations for XP_006503753.1

    Conserved Domains (3) summary
    cd00201
    Location:294322
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd01271
    Location:585711
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:417556
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
  6. XM_006503693.2XP_006503756.1  

    Conserved Domains (3) summary
    cd00201
    Location:294322
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd01271
    Location:564690
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:396535
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
  7. XM_006503692.2XP_006503755.1  

    Conserved Domains (3) summary
    cd00201
    Location:294322
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd01271
    Location:582708
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:417554
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
  8. XM_011240693.1XP_011238995.1  

    Conserved Domains (3) summary
    cd00201
    Location:294322
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd01271
    Location:584710
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:417556
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
  9. XM_006503688.2XP_006503751.1  

    See identical proteins and their annotated locations for XP_006503751.1

    Conserved Domains (3) summary
    cd00201
    Location:294322
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd01271
    Location:585711
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:417556
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
  10. XM_011240692.1XP_011238994.1  

    See identical proteins and their annotated locations for XP_011238994.1

    Conserved Domains (3) summary
    cd00201
    Location:294322
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd01271
    Location:585711
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:417556
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
  11. XM_006503691.2XP_006503754.1  

    See identical proteins and their annotated locations for XP_006503754.1

    Conserved Domains (3) summary
    cd00201
    Location:294322
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd01271
    Location:585711
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:417556
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
  12. XM_006503689.2XP_006503752.1  

    See identical proteins and their annotated locations for XP_006503752.1

    Conserved Domains (3) summary
    cd00201
    Location:294322
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd01271
    Location:585711
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:417556
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    63597353..63917571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)