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    Irbp Inverted repeat-binding protein [ Drosophila melanogaster ]

    Gene ID: 117419, updated on 10-May-2012
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    Summary

    Official Symbol
    Irbpprovided by Flybase
    Official Full Name
    Inverted repeat-binding proteinprovided by Flybase
    Primary source
    FLYBASE:FBgn0011774
    Locus tag
    Dmel_CG5247
    Gene type
    protein coding
    RNA name
    inverted repeat-binding protein
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5247; Dmel\CG5247; DmKu70; dp70; irbp; IRBP; IRBP/Ku70; Ku; ku70; Ku70; p70; YPF1; Ypf1b; YPF1beta
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    Genomic context

    Location :
    86E4-86E4
    Sequence :
    Chromosome: 3R; NT_033777.2 (7235770..7238162)
    See Irbp in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L40 Neighboring gene CG6719 gene product from transcript CG6719-RA Neighboring gene ncRNA Neighboring gene CG5252 gene product from transcript CG5252-RA Neighboring gene CG6723 gene product from transcript CG6723-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease. Tamura T, et al. PLoS One, 2011. PMID 22096569.
    2. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    3. Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. Blanco E, et al. BMC Dev Biol, 2010 Sep 2. PMID 20813047.
    4. Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions. Yu AM, et al. Nucleic Acids Res, 2010 Sep. PMID 20460465.
    5. Telomeric position effect--a third silencing mechanism in eukaryotes. Doheny JG, et al. PLoS One, 2008. PMID 19057646.

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Results collectively support that Ku70 is a critical mediator of the HD pathology and a candidate therapeutic target in HD.
      Title: Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease.
    2. Role for Ku subunits in the regulation of sperm individualization.
      Title: Up-regulation of the Ku heterodimer in Drosophila testicular cyst cells.
    3. Decrease in gene dosage causes a sharp increase in the frequency of HeT-A and TART attachments to a broken chromosome end and in terminal DNA elongation by gene conversion.
      Title: The Ku protein complex is involved in length regulation of Drosophila telomeres.
    4. Coding sequence of Ku70 gene is wild-type in two mus309 mutant lines.
      Title: The Drosophila melanogaster Ku70 coding sequence is wild-type in mus309 mutants.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:72892 BioGRID:65816 CG1126    BioGRID  PubMed Two-hybrid 
    BioGRID:72892 BioGRID:63867 CG11486    BioGRID  PubMed Two-hybrid 
    BioGRID:72892 BioGRID:63990 CG1332    BioGRID  PubMed Two-hybrid 
    BioGRID:72892 BioGRID:59158 CG15047    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72892 BioGRID:58522 CG15220    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72892 BioGRID:67501 CG16791    BioGRID  PubMed Two-hybrid 
    BioGRID:72892 BioGRID:58329 CG17446    BioGRID  PubMed Two-hybrid 
    BioGRID:72892 BioGRID:63504 CG3548    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72892 BioGRID:59085 CG8142    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72892 BioGRID:65822 Gnf1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72892 BioGRID:59912 His3.3A    BioGRID  PubMed Two-hybrid 
    BioGRID:72892 BioGRID:60943 Ku80    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72892 BioGRID:58699 Lig4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72892 BioGRID:78234 Parp    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72892 BioGRID:61322 RPA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72892 BioGRID:60505 RfC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72892 BioGRID:60612 RfC38    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72892 BioGRID:63972 RfC4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72892 BioGRID:59069 RhoGAPp190    BioGRID  PubMed Two-hybrid 
    BioGRID:72892 BioGRID:66153 RpA-70    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72892 BioGRID:64525 SH3PX1    BioGRID  PubMed Two-hybrid 
    BioGRID:72892 BioGRID:60577 Stam    BioGRID  PubMed Two-hybrid 
    BioGRID:72892 BioGRID:67411 TFAM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72892 BioGRID:59464 al    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72892 BioGRID:64513 fry    BioGRID  PubMed Two-hybrid 
    BioGRID:72892 BioGRID:62723 grh    BioGRID  PubMed Two-hybrid 
    BioGRID:72892 BioGRID:71041 hbn    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72892 BioGRID:70064 l(2)01289    BioGRID  PubMed Two-hybrid 
    BioGRID:72892 BioGRID:66499 mus309    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:72892 BioGRID:77440 scramb1    BioGRID  PubMed Two-hybrid 
    BioGRID:72892 BioGRID:71315 ttk    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Pathways from BioSystems

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP-dependent DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ATP-dependent DNA helicase activity NAS
    Non-traceable Author Statement
    more info
    		  
    DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    DNA binding NAS
    Non-traceable Author Statement
    more info
    		  
    DNA-dependent protein kinase activity NAS
    Non-traceable Author Statement
    more info
    		  
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    double-strand break repair via nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		  
    telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    DNA-dependent protein kinase-DNA ligase 4 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    Ku70:Ku80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CG5247 gene product from transcript CG5247-RA
    Names
    CG5247-PA
    Irbp-PA
    inverted repeat-binding protein
    yolk protein factor 1b
    NP_536773.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      7235770..7238162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080512.4 → NP_536773.1  inverted repeat-binding protein [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23976
      Related
      FBpp0081861
      Conserved Domains (4) summary
      cd01458
      Location:31 – 246
      Blast Score: 389
      vWA_ku; Ku70/Ku80 N-terminal domain. The Ku78 heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks (DSB) in a preferred orientation. DSB's are repaired by either homologues recombination or ...
      cd00788
      Location:255 – 546
      Blast Score: 605
      KU70; Ku-core domain, Ku70 subfamily; Ku70 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the ...
      TIGR00578
      Location:28 – 628
      Blast Score: 441
      ku70; ATP-dependent DNA helicase II, 70 kDa subunit (ku70)
      pfam12949
      Location:593 – 628
      Blast Score: 80
      HeH; HeH/LEM domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014297.2 AAF54631.1
    mRNA BT044080.1 ACH92145.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23976.3 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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