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Ubr5 ubiquitin protein ligase E3 component n-recognin 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117060, updated on 26-May-2016
Symbol
Ubr5provided by RGD
Full Name
ubiquitin protein ligase E3 component n-recognin 5provided by RGD
Primary source
RGD:621236
See related
Ensembl:ENSRNOG00000006816
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Dd5; Rat100
Summary
may be involved in sexual maturation [RGD, Feb 2006]
Orthologs
Location:
7q22
Exon count:
57
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (76839669..76907441, complement) , (76789110..76835518, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (76906390..76952033, complement)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692888 Neighboring gene ribonucleotide reductase regulatory TP53 inducible subunit M2B Neighboring gene uncharacterized LOC103692889 Neighboring gene similar to poly (A) polymerase beta (testis specific)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-ubiquitin ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of double-strand break repair IEA
Inferred from Electronic Annotation
more info
 
negative regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
negative regulation of double-strand break repair ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of histone H2A K63-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 
negative regulation of histone H2A K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
negative regulation of histone H2A K63-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of catenin import into nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of catenin import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein import into nucleus, translocation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein import into nucleus, translocation ISO
Inferred from Sequence Orthology
more info
 
progesterone receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
progesterone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
progesterone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
E3 ubiquitin-protein ligase UBR5
Names
E3 ubiquitin-protein ligase UBR5-like
E3 ubiquitin-protein ligase, HECT domain-containing 1
hyperplastic discs protein homolog
progestin-induced protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    76789110..76835518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    76839669..76907441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241570.2XP_006241632.2  

    Conserved Domains (4) summary
    smart00396
    Location:523590
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:17351798
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:18462141
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cl00077
    Location:18482142
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  2. XM_008765469.1XP_008763691.1  

    Conserved Domains (4) summary
    smart00396
    Location:540607
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:17521815
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:18612156
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cl00077
    Location:18632157
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  3. XM_008765468.1XP_008763690.1  

    See identical proteins and their annotated locations for XP_008763690.1

    Related
    ENSRNOP00000009115, ENSRNOT00000009115
    Conserved Domains (4) summary
    smart00396
    Location:540607
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:17521815
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:18632158
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cl00077
    Location:18652159
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    66180301..66255438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006226059.2XP_006226121.1  

    Conserved Domains (4) summary
    smart00396
    Location:912979
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:21242187
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:22352530
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cl00077
    Location:22372531
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  2. XM_008776462.1XP_008774684.1  

    See identical proteins and their annotated locations for XP_008774684.1

    Conserved Domains (4) summary
    smart00396
    Location:540607
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:17521815
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:18632158
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cl00077
    Location:18652159
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001191990.1: Suppressed sequence

    Description
    NM_001191990.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
  2. NM_053989.1: Suppressed sequence

    Description
    NM_053989.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.