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Amelx amelogenin, X-linked [ Mus musculus (house mouse) ]

Gene ID: 11704, updated on 24-Jan-2015
Official Symbol
Amelxprovided by MGI
Official Full Name
amelogenin, X-linkedprovided by MGI
Primary source
MGI:MGI:88005
Locus tag
RP23-334F21.1
See related
Ensembl:ENSMUSG00000031354; Vega:OTTMUSG00000019595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Amg; ALGN; AMGL; AMGX; Amel; LRAP; M100888; Rgsc888
Orthologs
See Amelx in MapViewer
Location:
X F5; X 78.95 cM
Exon count:
9
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) X NC_000086.7 (169175363..169187295, complement)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 4 Neighboring gene coiled-coil-helix-coiled-coil-helix domain-containing protein 5-like Neighboring gene male-specific lethal 3 homolog (Drosophila) Neighboring gene Rho GTPase activating protein 6 Neighboring gene uncharacterized LOC101055907 Neighboring gene cDNA sequence BC022960 Neighboring gene holocytochrome c synthetase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (1) 

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
growth factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
hydroxyapatite binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of tooth enamel ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
tooth mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
amelogenin, X isoform
Names
amelogenin, X isoform
enamel matrix protein
amelogenin X chromosome
leucine-rich amelogenin peptide

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081978.2NP_001075447.1  amelogenin, X isoform isoform 1 precursor

    See proteins identical to NP_001075447.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK029358, BC059090
    Consensus CDS
    CCDS41213.1
    UniProtKB/Swiss-Prot
    P63277
    UniProtKB/TrEMBL
    Q6PCW7
    Related
    ENSMUSP00000065966, OTTMUSP00000021171, ENSMUST00000066112, OTTMUST00000046811
    Conserved Domains (1) summary
    smart00818
    Location:28195
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
  2. NM_001290371.1NP_001277300.1  amelogenin, X isoform isoform 3 precursor

    See proteins identical to NP_001277300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple differences, compared to variant 1, including using an alternate 3' terminal exon. The encoded isoform (3) is shorter than isoform 1 and has a distinct C-terminus.
    Source sequence(s)
    KC731591
    UniProtKB/Swiss-Prot
    P63277
    UniProtKB/TrEMBL
    R9W2T8
    Conserved Domains (1) summary
    smart00818
    Location:28172
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
  3. NM_009666.4NP_033796.1  amelogenin, X isoform isoform 2 precursor

    See proteins identical to NP_033796.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK029358, KC731591
    Consensus CDS
    CCDS41214.1
    UniProtKB/Swiss-Prot
    P63277
    UniProtKB/TrEMBL
    R9W2T8
    Related
    ENSMUSP00000107746, OTTMUSP00000021169, ENSMUST00000112118, OTTMUST00000046809
    Conserved Domains (1) summary
    smart00818
    Location:28196
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000086.7 

    Range
    169175363..169187295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528693.1XP_006528756.1  

    Conserved Domains (1) summary
    pfam02948
    Location:1749
    Amelogenin; Amelogenin
  2. XM_006528691.1XP_006528754.1  

    Conserved Domains (1) summary
    smart00818
    Location:49209
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
  3. XM_006528692.1XP_006528755.1  

    See proteins identical to XP_006528755.1

    UniProtKB/Swiss-Prot
    P63277
    Related
    ENSMUSP00000107747, OTTMUSP00000021172, ENSMUST00000112119, OTTMUST00000046812
    Conserved Domains (1) summary
    smart00818
    Location:49210
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth

Alternate Mm_Celera

Genomic

  1. AC_000042.1 

    Range
    152339918..152351218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)