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Alox5 arachidonate 5-lipoxygenase [ Mus musculus (house mouse) ]

Gene ID: 11689, updated on 15-May-2016
Official Symbol
Alox5provided by MGI
Official Full Name
arachidonate 5-lipoxygenaseprovided by MGI
Primary source
MGI:MGI:87999
See related
Ensembl:ENSMUSG00000025701 Vega:OTTMUSG00000036516
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5LO; 5LX; 5-LO; 5-LOX; AI850497; F730011J02
Orthologs
Location:
6 F1; 6 53.79 cM
Exon count:
14
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (116410069..116461210, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (116360089..116411196, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene zinc finger, AN1-type domain 4 Neighboring gene membrane-associated ring finger (C3HC4) 8 Neighboring gene predicted gene, 38880 Neighboring gene olfactory receptor 211 Neighboring gene olfactory receptor 212

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
arachidonate 5-lipoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
iron ion binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
arachidonic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukotriene biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
leukotriene biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukotriene biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
leukotriene metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukotriene production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipoxygenase pathway ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope lumen ISO
Inferred from Sequence Orthology
more info
 
nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
arachidonate 5-lipoxygenase
Names
5-lipoxygenase
NP_033792.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009662.2NP_033792.1  arachidonate 5-lipoxygenase

    See identical proteins and their annotated locations for NP_033792.1

    Status: VALIDATED

    Source sequence(s)
    AK171413, BY205433, BY555055
    Consensus CDS
    CCDS20452.1
    UniProtKB/Swiss-Prot
    P48999
    Related
    ENSMUSP00000026795, OTTMUSP00000051997, ENSMUST00000026795, OTTMUST00000093640
    Conserved Domains (2) summary
    cd01753
    Location:2115
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:125666
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    116410069..116461210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241155.1XP_011239457.1  

    Conserved Domains (2) summary
    cd01753
    Location:2115
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:125569
    Lipoxygenase; Lipoxygenase

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    118247670..118299116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)