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LEAP2 liver expressed antimicrobial peptide 2 [ Homo sapiens (human) ]

Gene ID: 116842, updated on 7-May-2016
Official Symbol
LEAP2provided by HGNC
Official Full Name
liver expressed antimicrobial peptide 2provided by HGNC
Primary source
HGNC:HGNC:29571
See related
Ensembl:ENSG00000164406 HPRD:17269; MIM:611373
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LEAP-2
Summary
This gene encodes a cysteine-rich cationic antimicrobial peptide that is expressed predominantly in the liver. The mature peptide has activity against gram-positive bacteria and yeasts. [provided by RefSeq, Sep 2014]
Orthologs
Location:
5q31.1
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (132873666..132874890)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132209358..132210582)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 192 Neighboring gene growth differentiation factor 9 Neighboring gene ubiquinol-cytochrome c reductase complex III subunit VII Neighboring gene AF4/FMR2 family member 4 Neighboring gene eukaryotic translation elongation factor 1 alpha 2 pseudogene Neighboring gene ATPase H+ transporting V0 subunit e1 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Potential readthrough

Included gene: UQCRQ

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
liver-expressed antimicrobial peptide 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052971.2NP_443203.1  liver-expressed antimicrobial peptide 2 precursor

    See identical proteins and their annotated locations for NP_443203.1

    Status: REVIEWED

    Source sequence(s)
    AJ409065, BX443829
    Consensus CDS
    CCDS4163.1
    UniProtKB/Swiss-Prot
    Q969E1
    Related
    ENSP00000296877, OTTHUMP00000066208, ENST00000296877, OTTHUMT00000133046
    Conserved Domains (1) summary
    pfam07359
    Location:177
    LEAP-2; Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    132873666..132874890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    131642645..131643869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)