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Alox12 arachidonate 12-lipoxygenase [ Mus musculus (house mouse) ]

Gene ID: 11684, updated on 8-May-2016
Official Symbol
Alox12provided by MGI
Official Full Name
arachidonate 12-lipoxygenaseprovided by MGI
Primary source
MGI:MGI:87998
See related
Ensembl:ENSMUSG00000000320 Vega:OTTMUSG00000006035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P-12LO; Alox12p; 9930022G08Rik
Orthologs
Location:
11 B3; 11 42.99 cM
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (70241455..70255386, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (70054957..70068843, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 0610010K14 gene Neighboring gene ribonuclease, RNase K Neighboring gene predicted gene, 40191 Neighboring gene predicted gene, 32992 Neighboring gene predicted gene, 33048

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
arachidonate 12-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
arachidonate 12-lipoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
epoxide hydrolase A activity IEA
Inferred from Electronic Annotation
more info
 
epoxide hydrolase B activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
juvenile hormone epoxide hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
linoleate 13S-lipoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
Inferred from Electronic Annotation
more info
 
phenanthrene-1,2-epoxide hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phenanthrene-3,4-epoxide hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity IEA
Inferred from Electronic Annotation
more info
 
phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity IEA
Inferred from Electronic Annotation
more info
 
phenanthrene-9,10-epoxide hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phenanthrene-epoxide hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
pyrene-4,5-epoxide hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
arachidonic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
arachidonic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
establishment of skin barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
hepoxilin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipoxin A4 biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
lipoxin B4 biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
lipoxygenase pathway IDA
Inferred from Direct Assay
more info
PubMed 
lipoxygenase pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipoxygenase pathway ISO
Inferred from Sequence Orthology
more info
 
movement of cell or subcellular component ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
arachidonate 12-lipoxygenase, 12S-type
Names
12S-LOX
12S-lipoxygenase
lipoxin synthase 12-LO
platelet-type lipoxygenase 12
NP_031466.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007440.4NP_031466.2  arachidonate 12-lipoxygenase, 12S-type

    See identical proteins and their annotated locations for NP_031466.2

    Status: VALIDATED

    Source sequence(s)
    AK087724, AL669869
    Consensus CDS
    CCDS24942.1
    UniProtKB/Swiss-Prot
    P39655
    UniProtKB/TrEMBL
    A2CF85
    Related
    ENSMUSP00000000329, OTTMUSP00000006289, ENSMUST00000000329, OTTMUST00000013572
    Conserved Domains (2) summary
    cd01753
    Location:2111
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:124655
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    70241455..70255386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248677.1XP_011246979.1  

    See identical proteins and their annotated locations for XP_011246979.1

    Conserved Domains (1) summary
    pfam00305
    Location:2492
    Lipoxygenase; Lipoxygenase
  2. XM_011248676.1XP_011246978.1  

    See identical proteins and their annotated locations for XP_011246978.1

    Conserved Domains (2) summary
    pfam00305
    Location:89620
    Lipoxygenase; Lipoxygenase
    cl00011
    Location:976
    PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...
  3. XM_011248678.1XP_011246980.1  

    See identical proteins and their annotated locations for XP_011246980.1

    Conserved Domains (1) summary
    pfam00305
    Location:2492
    Lipoxygenase; Lipoxygenase

RNA

  1. XR_388333.2 RNA Sequence

Reference GRCm38.p3 NOD/MrkTac

Genomic

  1. NT_187026.1 Reference GRCm38.p3 NOD/MrkTac

    Range
    345966..359898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011251257.1XP_011249559.1  

    See identical proteins and their annotated locations for XP_011249559.1

    Conserved Domains (1) summary
    pfam00305
    Location:2492
    Lipoxygenase; Lipoxygenase
  2. XM_011251256.1XP_011249558.1  

    See identical proteins and their annotated locations for XP_011249558.1

    Conserved Domains (2) summary
    pfam00305
    Location:89620
    Lipoxygenase; Lipoxygenase
    cl00011
    Location:976
    PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...
  3. XM_011251258.1XP_011249560.1  

    See identical proteins and their annotated locations for XP_011249560.1

    Conserved Domains (1) summary
    pfam00305
    Location:2492
    Lipoxygenase; Lipoxygenase

RNA

  1. XR_390223.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    77785930..77799829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)