Format

Send to:

Choose Destination

Rims1 regulating synaptic membrane exocytosis 1 [ Mus musculus (house mouse) ]

Gene ID: 116837, updated on 8-May-2016
Official Symbol
Rims1provided by MGI
Official Full Name
regulating synaptic membrane exocytosis 1provided by MGI
Primary source
MGI:MGI:2152971
See related
Ensembl:ENSMUSG00000041670
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rim; RIM1; RIM1a; Serg1; Rab3ip1; RIM1alpha; mKIAA0340; C030033M19Rik
Annotation information
Annotation category: suggests misassembly
Annotation category: partial on reference assembly
Orthologs
Location:
1; 1 A5
Exon count:
32
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (22468191..22805724, complement) , (22288422..22432843, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (22475024..22812563, complement) , (22278503..22422924, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, subfamily Q, member 5 Neighboring gene eukaryotic translation initiation factor 3, subunit M pseudogene Neighboring gene transmembrane emp24 domain trafficking protein 2 pseudogene Neighboring gene predicted gene 7759 Neighboring gene predicted gene 7761

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
    Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
    Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • Synaptic vesicle cycle, organism-specific biosystem (from KEGG)
    Synaptic vesicle cycle, organism-specific biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
  • Synaptic vesicle cycle, conserved biosystem (from KEGG)
    Synaptic vesicle cycle, conserved biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0340

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Rab GTPase binding ISO
Inferred from Sequence Orthology
more info
 
SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
calcium ion-regulated exocytosis of neurotransmitter IGI
Inferred from Genetic Interaction
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
exocytosis IEA
Inferred from Electronic Annotation
more info
 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
positive regulation of excitatory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of inhibitory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of inhibitory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic vesicle priming ISO
Inferred from Sequence Orthology
more info
 
protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
spontaneous neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 
presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
regulating synaptic membrane exocytosis protein 1
Names
RIM 1
Rab3 effector
Rab3 interacting protein 1
rab-3-interacting molecule 1
rab-3-interacting protein 1
rab3-interacting molecule 1
rab3-interacting protein 1
regulating synaptic membrane exocytosis 1 beta
synaptic exocytosis regulator 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012623.1NP_001012641.1  regulating synaptic membrane exocytosis protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001012641.1

    Status: PROVISIONAL

    Source sequence(s)
    AY356536
    UniProtKB/Swiss-Prot
    Q99NE5
    Related
    ENSMUSP00000095418, ENSMUST00000097809
    Conserved Domains (5) summary
    cd04028
    Location:12051350
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:577703
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:439524
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12877
    Location:720928
    DUF3827; Domain of unknown function (DUF3827)
    cl22851
    Location:154209
    PHD_SF; PHD finger superfamily
  2. NM_001012624.1NP_001012642.1  regulating synaptic membrane exocytosis protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001012642.1

    Status: PROVISIONAL

    Source sequence(s)
    AY356537
    UniProtKB/Swiss-Prot
    Q99NE5
    Related
    ENSMUSP00000110928, ENSMUST00000115273
    Conserved Domains (4) summary
    cd04028
    Location:11811326
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:577703
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:439524
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:154209
    PHD_SF; PHD finger superfamily
  3. NM_001012625.1NP_001012643.1  regulating synaptic membrane exocytosis protein 1 isoform 5

    See identical proteins and their annotated locations for NP_001012643.1

    Status: PROVISIONAL

    Source sequence(s)
    AY356538
    UniProtKB/Swiss-Prot
    Q99NE5
    Related
    ENSMUSP00000080259, ENSMUST00000081544
    Conserved Domains (4) summary
    cd04028
    Location:11301275
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:577703
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:439524
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:154209
    PHD_SF; PHD finger superfamily
  4. NM_053270.1NP_444500.1  regulating synaptic membrane exocytosis protein 1 isoform 1

    See identical proteins and their annotated locations for NP_444500.1

    Status: PROVISIONAL

    Source sequence(s)
    AY356534
    UniProtKB/Swiss-Prot
    Q99NE5
    Related
    ENSMUSP00000095420, ENSMUST00000097811
    Conserved Domains (5) summary
    cd04028
    Location:12941439
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:577703
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:761947
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:439524
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:154209
    PHD_SF; PHD finger superfamily
  5. NM_183018.2NP_898839.2  regulating synaptic membrane exocytosis protein 1 isoform 2

    See identical proteins and their annotated locations for NP_898839.2

    Status: PROVISIONAL

    Source sequence(s)
    AY356535
    UniProtKB/Swiss-Prot
    Q99NE5
    Related
    ENSMUSP00000095419, ENSMUST00000097810
    Conserved Domains (5) summary
    cd04028
    Location:12661411
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:577703
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:761970
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:439524
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:154209
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    22288422..22432843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    22468191..22805724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    22160697..22651999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)