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HSPA12B heat shock 70kD protein 12B [ Homo sapiens (human) ]

Gene ID: 116835, updated on 19-Nov-2014
Official Symbol
HSPA12Bprovided by HGNC
Official Full Name
heat shock 70kD protein 12Bprovided by HGNC
Primary source
HGNC:HGNC:16193
Locus tag
RP5-1009E24.4
See related
Ensembl:ENSG00000132622; HPRD:13683; MIM:610702; Vega:OTTHUMG00000031755
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf60; dJ1009E24.2
Summary
The protein encoded by this gene contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
See HSPA12B in Epigenomics, MapViewer
Location:
20p13
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 20 NC_000020.11 (3732670..3753111)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3713317..3733758)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 33 Neighboring gene sialic acid binding Ig-like lectin 1, sialoadhesin Neighboring gene chromosome 20 open reading frame 27 Neighboring gene sperm flagellar 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity PubMed
env The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein PubMed

Go to the HIV-1, Human Interaction Database

Markers

Homology

Clone Names

  • FLJ32150, MGC131912

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
heat shock 70 kDa protein 12B
Names
heat shock 70 kDa protein 12B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197327.1NP_001184256.1  heat shock 70 kDa protein 12B isoform 2

    See proteins identical to NP_001184256.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is 1 amino acid shorter than isoform 1.
    Source sequence(s)
    AL109804, BC110881, BC117284, BC143932
    UniProtKB/TrEMBL
    B7ZLP2
    UniProtKB/Swiss-Prot
    Q96MM6
    Conserved Domains (1) summary
    cl17037
    Location:61528
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. NM_052970.4NP_443202.3  heat shock 70 kDa protein 12B isoform 1

    See proteins identical to NP_443202.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL109804, BC110881, BC117284
    Consensus CDS
    CCDS13061.1
    UniProtKB/Swiss-Prot
    Q96MM6
    Related
    ENSP00000254963, OTTHUMP00000030119, ENST00000254963, OTTHUMT00000077756
    Conserved Domains (1) summary
    cd11736
    Location:61529
    HSPA12B_like_NBD; Nucleotide-binding domain of HSPA12B and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Alternate HuRef

Genomic

  1. AC_000152.1 

    Range
    3661829..3682263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 

    Range
    3732670..3753111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260656.1XP_005260713.1  

    UniProtKB/TrEMBL
    Q5JX83
    Related
    ENSP00000382608, OTTHUMP00000030120, ENST00000399701, OTTHUMT00000077757
    Conserved Domains (1) summary
    cl17037
    Location:1443
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. XM_005260657.2XP_005260714.2  

    Conserved Domains (1) summary
    cl17037
    Location:61468
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. XM_005260658.2XP_005260715.1  

    Conserved Domains (1) summary
    cl17037
    Location:61468
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 

    Range
    3713652..3734075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)