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HSPA12B heat shock protein family A (Hsp70) member 12B [ Homo sapiens (human) ]

Gene ID: 116835, updated on 3-Apr-2016
Official Symbol
HSPA12Bprovided by HGNC
Official Full Name
heat shock protein family A (Hsp70) member 12Bprovided by HGNC
Primary source
HGNC:HGNC:16193
See related
Ensembl:ENSG00000132622 HPRD:13683; MIM:610702; Vega:OTTHUMG00000031755
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf60
Summary
The protein encoded by this gene contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Orthologs
Location:
20p13
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 20 NC_000020.11 (3732670..3753111)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3713317..3733758)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 33 Neighboring gene sialic acid binding Ig like lectin 1 Neighboring gene chromosome 20 open reading frame 27 Neighboring gene sperm flagellar 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity PubMed
env The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein PubMed

Go to the HIV-1, Human Interaction Database

  • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
    Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Regulation of HSF1-mediated heat shock response, organism-specific biosystem (from REACTOME)
    Regulation of HSF1-mediated heat shock response, organism-specific biosystemThe ability of HSF1 to respond to cellular stresses is under negative regulation by chaperones, modulation of nucleocytoplasmic shuttling, post-translational modifications and transition from monomer...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ32150, MGC131912, dJ1009E24.2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Preferred Names
heat shock 70 kDa protein 12B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197327.1NP_001184256.1  heat shock 70 kDa protein 12B isoform 2

    See identical proteins and their annotated locations for NP_001184256.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL109804, BC110881, BC117284, BC143932
    UniProtKB/Swiss-Prot
    Q96MM6
    UniProtKB/TrEMBL
    B7ZLP2
    Conserved Domains (1) summary
    cl17037
    Location:61528
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. NM_001318322.1NP_001305251.1  heat shock 70 kDa protein 12B isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon, resulting in a distinct 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK297120, BC090857, CB990660
    UniProtKB/TrEMBL
    B4DLR4, Q5BKZ8, Q5JX83
    Conserved Domains (1) summary
    cl17037
    Location:1443
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. NM_052970.4NP_443202.3  heat shock 70 kDa protein 12B isoform 1

    See identical proteins and their annotated locations for NP_443202.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL109804, BC110881, BC117284
    Consensus CDS
    CCDS13061.1
    UniProtKB/Swiss-Prot
    Q96MM6
    Related
    ENSP00000254963, OTTHUMP00000030119, ENST00000254963, OTTHUMT00000077756
    Conserved Domains (1) summary
    cl17037
    Location:61529
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p2 Primary Assembly

    Range
    3732670..3753111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260656.2XP_005260713.1  

    Related
    ENSP00000382608, OTTHUMP00000030120, ENST00000399701, OTTHUMT00000077757
    Conserved Domains (1) summary
    cl17037
    Location:1443
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. XM_011529149.1XP_011527451.1  

    Conserved Domains (1) summary
    cd11736
    Location:85553
    HSPA12B_like_NBD; Nucleotide-binding domain of HSPA12B and similar proteins
  3. XM_011529150.1XP_011527452.1  

    Conserved Domains (1) summary
    cl17037
    Location:85492
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  4. XM_011529152.1XP_011527454.1  

    Conserved Domains (1) summary
    cl17037
    Location:85492
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  5. XM_011529151.1XP_011527453.1  

    See identical proteins and their annotated locations for XP_011527453.1

    UniProtKB/TrEMBL
    B4DLR4
    Conserved Domains (1) summary
    cl17037
    Location:1363
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    3713652..3734075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)