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Fxyd3 FXYD domain-containing ion transport regulator 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116831, updated on 3-Apr-2024

Summary

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Official Symbol
Fxyd3provided by RGD
Official Full Name
FXYD domain-containing ion transport regulator 3provided by RGD
Primary source
RGD:620825
See related
AllianceGenome:RGD:620825
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MAT8
Summary
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. [provided by RefSeq, Jul 2008]
Expression
Biased expression in Lung (RPKM 104.5), Brain (RPKM 31.3) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95432918..95440129, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86305531..86312455, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89502561..89510146, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene FXYD domain-containing ion transport regulator 7 Neighboring gene FXYD domain-containing ion transport regulator 1 Neighboring gene leucine-rich repeat LGI family, member 4 Neighboring gene uncharacterized LOC134483096 Neighboring gene hepsin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FXYD3 (Mat-8), a new regulator of Na,K-ATPase. Crambert G, et al. Mol Biol Cell, 2005 May. PMID 15743908, Free PMC Article
  2. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Sweadner KJ, et al. Genomics, 2000 Aug 15. PMID 10950925
  3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FXYD domain-containing ion transport regulator 3
Names
sodium/potassium-transporting ATPase subunit FXYD3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172317.2 → NP_758528.1  FXYD domain-containing ion transport regulator 3 precursor

    See identical proteins and their annotated locations for NP_758528.1

    Status: REVIEWED

    Source sequence(s)
    BG373727, DY471861
    UniProtKB/Swiss-Prot
    P59645
    UniProtKB/TrEMBL
    A6JA66
    Conserved Domains (1) summary
    cd20328
    Location:20 → 70
    FXYD3-like; FXYD domain-containing ion transport regulator 3 and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    95432918..95440129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266166.1 → XP_063122236.1  FXYD domain-containing ion transport regulator 3 isoform X2

    UniProtKB/Swiss-Prot
    P59645
    UniProtKB/TrEMBL
    A6JA66

  2. XM_063266111.1 → XP_063122181.1  FXYD domain-containing ion transport regulator 3 isoform X1

  3. XM_063266144.1 → XP_063122214.1  FXYD domain-containing ion transport regulator 3 isoform X1

  4. XM_063266203.1 → XP_063122273.1  FXYD domain-containing ion transport regulator 3 isoform X2

    UniProtKB/Swiss-Prot
    P59645
    UniProtKB/TrEMBL
    A6JA66

  5. XM_006228819.5 → XP_006228881.1  FXYD domain-containing ion transport regulator 3 isoform X1

    See identical proteins and their annotated locations for XP_006228881.1

    Conserved Domains (1) summary
    cd20328
    Location:20 → 70
    FXYD3-like; FXYD domain-containing ion transport regulator 3 and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59645.1 GenPept UniProtKB/Swiss-Prot:P59645

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