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    Aldoc aldolase C, fructose-bisphosphate [ Mus musculus (house mouse) ]

    Gene ID: 11676, updated on 18-May-2013
    Official Symbol
    Aldocprovided by MGI
    Official Full Name
    aldolase C, fructose-bisphosphateprovided by MGI
    Primary source
    MGI:101863
    See related
    Ensembl:ENSMUSG00000017390; Vega:OTTMUSG00000000108
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aldo3; Scrg2; AI847350; AU040929
    Location :
    11 B5; 11 46.74 cM
    Sequence :
    Chromosome: 11; NC_000077.6 (78324198..78326760)
    See Aldoc in Epigenomics, MapViewer

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene 3948 Neighboring gene sperm associated antigen 5 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class S Neighboring gene unc-119 homolog (C. elegans)

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998.
    2. Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Lokireddy S, et al. Am J Physiol Cell Physiol, 2012 Sep 1. PMID 22673621.
    3. FoxP2 expression in the cerebellum and inferior olive: development of the transverse stripe-shaped expression pattern in the mouse cerebellar cortex. Fujita H, et al. J Comp Neurol, 2012 Feb 15. PMID 21935935.
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750.
    5. Zac1 plays a key role in the development of specific neuronal subsets in the mouse cerebellum. Chung SH, et al. Neural Dev, 2011 May 18. PMID 21592321.

    See all (50) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Studies indicate that zebrin II expression is essential for enhancing understanding of the pathogenesis of hereditary cerebellar ataxic mutants.
      Title: Zebrin II expressing Purkinje cell phenotype-related and -unrelated cerebellar abnormalities in Cav2.1 mutant, rolling mouse Nagoya.
    2. Chronic morphine administration induces over-expression of Aldoc with reduction of CREB phosphorylation in the mouse hippocampus.
      Title: Chronic morphine administration induces over-expression of aldolase C with reduction of CREB phosphorylation in the mouse hippocampus.
    3. Ebf2 regulates the expression of genes associated with the zebrin II+ Purkinje cell phenotype and that the zebrin II- Purkinje cell subtype is specified independently.
      Title: Purkinje cell subtype specification in the cerebellar cortex: early B-cell factor 2 acts to repress the zebrin II-positive Purkinje cell phenotype.
    4. The results from the present study indicate that aldolase C provides marked neuroprotection to PCs after trauma and excitotoxicity.
      Title: Aldolase C-positive cerebellar Purkinje cells are resistant to delayed death after cerebral trauma and AMPA-mediated excitotoxicity.
    5. the aldolase C compartments and olivocerebellar projection are organized according to a common fundamental organization in the mouse and rat
      Title: Identification of aldolase C compartments in the mouse cerebellar cortex by olivocerebellar labeling.
    6. A species difference between mouse and rat is found in both mRNA and protein expression of zebrin II/aldolase C in the cerebellum. There also appears to be a transition in expression that occurs in vivo between postnatal days 8 and 10.
      Title: Development of cerebellar modules: extrinsic control of late-phase zebrin II pattern and the exploration of rat/mouse species differences.
    7. Aldolase C (EC 4.1.2.13) is a brain-specific aldolase isoform and a putative target of the transcription factor hypoxia-inducible factor (HIF)-1
      Title: Hypoxia results in an HIF-1-dependent induction of brain-specific aldolase C in lung epithelial cells.
    8. The selective regulation of AldC/zebrin may contribute to a shift in nutrient metabolism during pregnancy and lactation to facilitate epithelial growth and biosynthesis of milk constituents.
      Title: Aldolase C/zebrin gene regulation by prolactin during pregnancy and lactation.
    Submit: New GeneRIF Correction
    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:198068 BioGRID:212401 Fbxo32    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    fructose-bisphosphate aldolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    fructose-bisphosphate aldolase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    aging ISO
    Inferred from Sequence Orthology
    more info
    		  
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    fructose 1,6-bisphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    glycolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    metabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    fructose-bisphosphate aldolase C
    Names
    fructose-bisphosphate aldolase C
    zebrin II
    brain-type aldolase
    aldolase 3, C isoform
    scrapie responsive gene 2
    scrapie-responsive protein 2
    NP_033787.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009657.3 → NP_033787.2  fructose-bisphosphate aldolase C

      Status: PROVISIONAL

      Source sequence(s)
      AK005077
      Consensus CDS
      CCDS25099.1
      UniProtKB/Swiss-Prot
      P05063
      Related
      ENSMUSP00000099536, OTTMUSP00000000161, ENSMUST00000102478, OTTMUST00000000366
      Conserved Domains (1) summary
      cd00948
      Location:13 – 343
      Blast Score: 1649
      FBP_aldolase_I_a; Fructose-1,6-bisphosphate aldolase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p1 C57BL/6J

      Range
      78324198..78326760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000033.1 Alternate Mm_Celera

      Range
      87956279..87958841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01094598.1 (815..3377) None
    genomic AL591070.19 (23229..25791) None
    genomic AY226907.1 (25518..28080) None 129/SvJ
    genomic CH466556.1 EDL15560.1 mixed
      EDL15561.1 mixed
      EDL15562.1 mixed
      EDL15563.1 mixed
      EDL15564.1 mixed
    mRNA AJ132391.1 CAB77178.1 BALB/c
    mRNA AK005077.1 BAB23801.1 C57BL/6J
    mRNA AK039267.1 BAC30300.1 C57BL/6J
    mRNA BC004802.1 AAH04802.1 CZECHII
    mRNA BC008184.1 AAH08184.1 CZECHII
    mRNA S72537.1 AAB32064.1
    mRNA X03796.1 CAA27422.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05063.4 GenPept UniProtKB/Swiss-Prot:P05063

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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