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Kynu kynureninase [ Rattus norvegicus (Norway rat) ]

Gene ID: 116682, updated on 3-May-2016
Official Symbol
Kynuprovided by RGD
Official Full Name
kynureninaseprovided by RGD
Primary source
RGD:71061
See related
Ensembl:ENSRNOG00000029993
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
enzyme involved in the biosynthesis of NAD cofactors from tryptophan [RGD, Feb 2006]
Orthologs
Location:
3q12
Exon count:
15
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (28416926..28566939)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (33622141..33770793)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551194 Neighboring gene MLV-related proviral Env polyprotein-like Neighboring gene uncharacterized LOC102547849 Neighboring gene Rho GTPase activating protein 15 Neighboring gene glycosyltransferase-like domain containing 1 Neighboring gene uncharacterized LOC103691778

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
kynureninase activity IDA
Inferred from Direct Assay
more info
PubMed 
kynureninase activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
pyridoxal phosphate binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
'de novo' NAD biosynthetic process from tryptophan IEA
Inferred from Electronic Annotation
more info
 
L-kynurenine catabolic process IEA
Inferred from Electronic Annotation
more info
 
anthranilate metabolic process IEA
Inferred from Electronic Annotation
more info
 
anthranilate metabolic process ISO
Inferred from Sequence Orthology
more info
 
quinolinate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
quinolinate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
 
response to interferon-gamma ISO
Inferred from Sequence Orthology
more info
 
response to vitamin B6 IEA
Inferred from Electronic Annotation
more info
 
response to vitamin B6 ISO
Inferred from Sequence Orthology
more info
 
tryptophan catabolic process ISO
Inferred from Sequence Orthology
more info
 
tryptophan catabolic process to acetyl-CoA IDA
Inferred from Direct Assay
more info
PubMed 
tryptophan catabolic process to kynurenine IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
kynureninase
Names
L-kynurenine hydrolase
NP_446354.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053902.2NP_446354.1  kynureninase

    See identical proteins and their annotated locations for NP_446354.1

    Status: PROVISIONAL

    Source sequence(s)
    U68168
    UniProtKB/Swiss-Prot
    P70712
    Related
    ENSRNOP00000050947, ENSRNOT00000043533
    Conserved Domains (2) summary
    TIGR01814
    Location:30459
    kynureninase; kynureninase
    cl18945
    Location:24462
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    28416926..28566939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234138.2XP_006234200.1  

    Conserved Domains (2) summary
    TIGR01814
    Location:30410
    kynureninase; kynureninase
    cl18945
    Location:24413
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  2. XM_008761695.1XP_008759917.1  

    Conserved Domains (1) summary
    cl18945
    Location:24301
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    26096675..26244576
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)