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Jdp2 Jun dimerization protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116674, updated on 13-Apr-2024

Summary

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Official Symbol
Jdp2provided by RGD
Official Full Name
Jun dimerization protein 2provided by RGD
Primary source
RGD:621611
See related
Ensembl:ENSRNOG00000063964 AllianceGenome:RGD:621611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Jundm2; Jundp2
Summary
Enables DNA-binding transcription factor activity and double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human JDP2 (Jun dimerization protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 60.0), Brain (RPKM 54.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (110988927..111033392)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (105261619..105302386)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (109464910..109505591)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479234 Neighboring gene Fos proto-oncogene, AP-1 transcription factor subunit Neighboring gene uncharacterized LOC108351275 Neighboring gene basic leucine zipper ATF-like transcription factor Neighboring gene uncharacterized LOC120103579 Neighboring gene FLVCR choline and putative heme transporter 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of the amino-terminal transcription activation domain of progesterone receptor by a cofactor-induced protein folding mechanism. Wardell SE, et al. Mol Cell Biol, 2005 Oct. PMID 16199860, Free PMC Article
  2. Candidate plasticity gene 16 and jun dimerization protein 2 are involved in the suppression of insulin gene expression in rat pancreatic INS-1 β-cells. Nakane T, et al. Mol Cell Endocrinol, 2021 May 1. PMID 33676985
  3. Identification of mouse Jun dimerization protein 2 as a novel repressor of ATF-2. Jin C, et al. FEBS Lett, 2001 Jan 26. PMID 11231009
  4. Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. Aronheim A, et al. Mol Cell Biol, 1997 Jun. PMID 9154808, Free PMC Article
  5. JDP2 suppresses adipocyte differentiation by regulating histone acetylation. Nakade K, et al. Cell Death Differ, 2007 Aug. PMID 17464331

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Candidate plasticity gene 16 and jun dimerization protein 2 are involved in the suppression of insulin gene expression in rat pancreatic INS-1 beta-cells.
    Title: Candidate plasticity gene 16 and jun dimerization protein 2 are involved in the suppression of insulin gene expression in rat pancreatic INS-1 β-cells.
  2. JDP-2 enhances transcriptional activity of progesterone receptor through a protein folding mechanism by an interdomain communication.
    Title: Regulation of the amino-terminal transcription activation domain of progesterone receptor by a cofactor-induced protein folding mechanism.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables cAMP response element binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone chaperone activity ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables leucine zipper domain binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within_negative_effect regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
jun dimerization protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053894.3 → NP_446346.1  jun dimerization protein 2

    See identical proteins and their annotated locations for NP_446346.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q78E65
    UniProtKB/TrEMBL
    A6JE34
    Conserved Domains (3) summary
    cd14686
    Location:82 → 132
    bZIP; coiled coil [structural motif]
    cl21453
    Location:18 → 61
    PKc_like; Protein Kinases, catalytic domain
    cl21462
    Location:82 → 135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    110988927..111033392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764734.4 → XP_008762956.1  jun dimerization protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008762956.1

    UniProtKB/TrEMBL
    A0A8I6GCN6, A6JE33
    Related
    ENSRNOP00000085253.1
    Conserved Domains (2) summary
    cd14722
    Location:231 → 284
    bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain
    cl21453
    Location:167 → 210
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q78E65.1 GenPept UniProtKB/Swiss-Prot:Q78E65

Gene LinkOut

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