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Abcd1 ATP-binding cassette, sub-family D (ALD), member 1 [ Mus musculus (house mouse) ]

Gene ID: 11666, updated on 26-Aug-2014
Official Symbol
Abcd1provided by MGI
Official Full Name
ATP-binding cassette, sub-family D (ALD), member 1provided by MGI
Primary source
MGI:1349215
Locus tag
RP23-373N8.2
See related
Ensembl:ENSMUSG00000031378; Vega:OTTMUSG00000017700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ald; ALDP; Aldgh
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in the human gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system. [provided by RefSeq, Jul 2008]
See Abcd1 in Epigenomics, MapViewer
Location:
X B; X 37.39 cM
Exon count:
10
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) X NC_000086.7 (73716597..73738287)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 (neurotransmitter transporter, creatine), member 8 Neighboring gene B cell receptor associated protein 31 Neighboring gene plexin B3 Neighboring gene serine/arginine-rich protein specific kinase 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
ATPase activity ISO
Inferred from Sequence Orthology
more info
 
ATPase activity, coupled to transmembrane movement of substances IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
peroxisomal fatty-acyl-CoA transporter activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
ATP catabolic process ISO
Inferred from Sequence Orthology
more info
 
fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
fatty-acyl-CoA transport ISO
Inferred from Sequence Orthology
more info
 
long-chain fatty acid catabolic process ISO
Inferred from Sequence Orthology
more info
 
peroxisomal long-chain fatty acid import ISO
Inferred from Sequence Orthology
more info
 
peroxisome organization ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
very long-chain fatty acid catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
peroxisome ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
ATP-binding cassette sub-family D member 1
Names
ATP-binding cassette sub-family D member 1
adrenoleukodystrophy protein
ATP-binding cassette, sub-family D, member 1
X-linked adrenoleukodystrophy (ALD) gene homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007435.1NP_031461.1  ATP-binding cassette sub-family D member 1

    See proteins identical to NP_031461.1

    Status: REVIEWED

    Source sequence(s)
    Z33637
    Consensus CDS
    CCDS30210.1
    UniProtKB/Swiss-Prot
    P48410
    Related
    ENSMUSP00000002084, OTTMUSP00000019283, ENSMUST00000002084, OTTMUST00000042898
    Conserved Domains (3) summary
    cd03223
    Location:474679
    Blast Score: 671
    ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
    TIGR00954
    Location:1681
    Blast Score: 2544
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protei
    pfam06472
    Location:65352
    Blast Score: 908
    ABC_membrane_2; ABC transporter transmembrane region 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000086.7 

    Range
    73716597..73738287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000042.1 

    Range
    64970295..64991971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)