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Calcr calcitonin receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 116506, updated on 17-May-2016
Official Symbol
Calcrprovided by RGD
Official Full Name
calcitonin receptorprovided by RGD
Primary source
RGD:621001
See related
Ensembl:ENSRNOG00000010053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
receptor for calcitonin; acts via adenylate cyclase signaling [RGD, Feb 2006]
Orthologs
Location:
4q13
Exon count:
16
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (28627439..28702559, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (28532077..28607201, complement)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene HEPACAM family member 2 Neighboring gene VPS50 EARP/GARPII complex subunit Neighboring gene uncharacterized LOC102551706 Neighboring gene microRNA 653 Neighboring gene microRNA 489 Neighboring gene tissue factor pathway inhibitor 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcitonin binding IDA
Inferred from Direct Assay
more info
PubMed 
calcitonin binding ISO
Inferred from Sequence Orthology
more info
 
NOT calcitonin binding ISO
Inferred from Sequence Orthology
more info
 
calcitonin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
calcitonin receptor activity IEA
Inferred from Electronic Annotation
more info
 
calcitonin receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein transporter activity ISO
Inferred from Sequence Orthology
more info
 
receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
NOT activation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
NOT activation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-modulating G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein transport ISO
Inferred from Sequence Orthology
more info
 
receptor internalization ISO
Inferred from Sequence Orthology
more info
 
NOT regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
regulation of mRNA stability IEA
Inferred from Electronic Annotation
more info
 
regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
 
response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
axon IDA
Inferred from Direct Assay
more info
PubMed 
cilium IEA
Inferred from Electronic Annotation
more info
 
cilium ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
calcitonin receptor
Names
C1A/C1B
CT-R

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034015.1NP_001029187.1  calcitonin receptor isoform 1a precursor

    See identical proteins and their annotated locations for NP_001029187.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1a, previously called 2), lacks an alternate in-frame exon compared to variant 1b. The resulting isoform (1a, previously called b), has the same N- and C-termini but is shorter compared to isoform 1b.
    Source sequence(s)
    CB791100, L14617
    UniProtKB/Swiss-Prot
    P32214
    UniProtKB/TrEMBL
    A0A0H2UHI3
    Related
    ENSRNOP00000013937, ENSRNOT00000013937
    Conserved Domains (2) summary
    pfam00002
    Location:162404
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:86154
    HRM; Hormone receptor domain
  2. NM_053816.2NP_446268.2  calcitonin receptor isoform 1b precursor

    See identical proteins and their annotated locations for NP_446268.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1b), previously called 1, represents the longer variant and encodes the longer isoform (1b, previously called a).
    Source sequence(s)
    CB791100, L14617, L14618
    UniProtKB/Swiss-Prot
    P32214
    UniProtKB/TrEMBL
    A0A0H2UHI1
    Related
    ENSRNOP00000013910, ENSRNOT00000013910
    Conserved Domains (2) summary
    pfam00002
    Location:162441
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:86154
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    28627439..28702559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    27047821..27123526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)