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GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B [ Homo sapiens (human) ]

Gene ID: 116444, updated on 19-Nov-2014
Official Symbol
GRIN3Bprovided by HGNC
Official Full Name
glutamate receptor, ionotropic, N-methyl-D-aspartate 3Bprovided by HGNC
Primary source
HGNC:HGNC:16768
See related
Ensembl:ENSG00000116032; MIM:606651; Vega:OTTHUMG00000181904
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NR3B; GluN3B
See GRIN3B in Epigenomics, MapViewer
Location:
19p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (1000438..1009724)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1000437..1009723)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene AT rich interactive domain 3A (BRIGHT-like) Neighboring gene WD repeat domain 18 Neighboring gene transmembrane protein 259 Neighboring gene calponin 2 Neighboring gene ATP-binding cassette, sub-family A (ABC1), member 7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced dephosphorylation of KV2.1 is dependent on NMDA receptor-mediated activation of protein phosphatase 2B or calcineurin PubMed
env HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896 PubMed
env HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells PubMed
env HIV-1 clade B gp120 significantly downregulates NMDA receptor gene and protein expression and levels of glutamine compared to clade C gp120 PubMed
env HIV-1 gp120 binds to cells expressing epsilon1/zeta1 or epsilon2/zeta1 combined NMDA receptor subunits, but not to cells expressing a single epsilon1, epsilon2, or zeta1 NMDA receptor subunit PubMed
env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120-mediated human cell death involves the NMDA receptor complex; antagonists of the NMDA receptor reverse the gp120-mediated effects PubMed
Tat tat HIV-1 Tat upregulates the expression of NMDARs for the apoptosis of retinal pigmen epithelium (RPE) cells. Silencing of NMDARs by siRNA abolishes Tat-induced RPE apoptosis PubMed
tat HIV-1 Tat interacts with NMDA receptors in primary neuronal-glial cultures and in hippocampal slice cultures PubMed
tat HIV-1 Tat and methamphetamine inhibit the normal conjunction of signaling between D1 and NMDA receptors, resulting in neural dysfunction and death PubMed
tat HIV-1 Tat induces apoptosis of neurons and neurotoxicity through the activation of both NMDA and non-NMDA receptors PubMed

Go to the HIV-1, Human Interaction Database

  • Alcoholism, organism-specific biosystem (from KEGG)
    Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Alcoholism, conserved biosystem (from KEGG)
    Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Amphetamine addiction, organism-specific biosystem (from KEGG)
    Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
  • Amphetamine addiction, conserved biosystem (from KEGG)
    Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
  • Cocaine addiction, organism-specific biosystem (from KEGG)
    Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • Cocaine addiction, conserved biosystem (from KEGG)
    Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • Glutamatergic synapse, organism-specific biosystem (from KEGG)
    Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Glutamatergic synapse, conserved biosystem (from KEGG)
    Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Nicotine addiction, organism-specific biosystem (from KEGG)
    Nicotine addiction, organism-specific biosystemNicotine is one of the main psychoactive ingredients in tobacco that contributes to the harmful tobacco smoking habit. A common feature of addictive drugs, including nicotine, is that they increase d...
  • Nicotine addiction, conserved biosystem (from KEGG)
    Nicotine addiction, conserved biosystemNicotine is one of the main psychoactive ingredients in tobacco that contributes to the harmful tobacco smoking habit. A common feature of addictive drugs, including nicotine, is that they increase d...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-methyl-D-aspartate selective glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular-glutamate-gated ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
glycine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
neurotransmitter binding ISS
Inferred from Sequence or Structural Similarity
more info
 
neurotransmitter receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
ionotropic glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
ionotropic glutamate receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
protein insertion into membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
N-methyl-D-aspartate selective glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
N-methyl-D-aspartate selective glutamate receptor complex NAS
Non-traceable Author Statement
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
glutamate receptor ionotropic, NMDA 3B
Names
glutamate receptor ionotropic, NMDA 3B
NMDAR3B
NMDA receptor subunit 3B
glutamate [NMDA] receptor subunit 3B
N-methyl-D-aspartate receptor subtype 3B
NMDA type glutamate receptor subunit NR3B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138690.1NP_619635.1  glutamate receptor ionotropic, NMDA 3B precursor

    See proteins identical to NP_619635.1

    Status: PROVISIONAL

    Source sequence(s)
    BK000070, CB243197
    Consensus CDS
    CCDS32861.1
    UniProtKB/Swiss-Prot
    O60391
    Related
    ENSP00000234389, OTTHUMP00000042007, ENST00000234389, OTTHUMT00000103923
    Conserved Domains (4) summary
    cd06377
    Location:19405
    PBP1_iGluR_NMDA_NR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family
    smart00079
    Location:676810
    PBPe; Eukaryotic homologues of bacterial periplasmic substrate binding proteins
    cd00134
    Location:478558
    PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
    pfam00060
    Location:576842
    Lig_chan; Ligand-gated ion channel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    773711..783359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003403700.2XP_003403748.2  

    Conserved Domains (4) summary
    smart00079
    Location:630764
    PBPe; Eukaryotic homologues of bacterial periplasmic substrate binding proteins
    cd00134
    Location:432512
    PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
    pfam00060
    Location:530796
    Lig_chan; Ligand-gated ion channel
    cl10011
    Location:22359
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    1000438..1009724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    999547..1008877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)