GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B [Homo sapiens] - Gene

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Summary

Official Symbol: GRIN3Bprovided by HGNC
Official Full Name: glutamate receptor, ionotropic, N-methyl-D-aspartate 3Bprovided by HGNC
Primary source: HGNC:16768
See related: Ensembl:ENSG00000116032; MIM:606651; Vega:OTTHUMG00000044546
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NR3B; GluN3B

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Genomic context

Location :: 19p13.3

Sequence :: Chromosome: 19; NC_000019.9 (1000437..1009723)

See GRIN3B in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our findings suggest that the over-expression of NR3B subunit of NMDA receptor is a long lasting result of chronic opioid abuse.
Title: Expression of NR3B but not NR2D subunit of NMDA receptor in human blood lymphocytes can serve as a suitable peripheral marker for opioid addiction studies.
These observations suggest that the genetic variation of the NR3B subunit of the NMDA receptor is not a risk factor for Alzheimer's dis pathogenesis
Title: Genetic variation in N-methyl-D-aspartate receptor subunit NR3A but not NR3B influences susceptibility to Alzheimer's disease.
Observational study of gene-disease association. (HuGE Navigator)
Title: Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.
Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
We tested whether genetic dysfunction of GRIN3B is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS).
Title: Motoneuron-specific NR3B gene: no association with ALS and evidence for a common null allele.
NR3B mRNA expression in the human hippocampal formation (CA1-CA4 and dentate gyrus) and adjacent neocortex may have implications for understanding the role of NMDA receptors for physiological and pathological processes in these forebrain regions.
Title: Cloning and expression of the human NMDA receptor subunit NR3B in the adult human hippocampus.
cross-talk between NR3B and NR4A receptors is a mechanism modulating the transcriptional activities of these orphan nuclear receptors
Title: Cross-talk between the NR3B and NR4A families of orphan nuclear receptors.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells	PubMed
	env	HIV-1 gp120 binds to cells expressing epsilon1/zeta1 or epsilon2/zeta1 combined NMDA receptor subunits, but not to cells expressing a single epsilon1, epsilon2, or zeta1 NMDA receptor subunit	PubMed
	env	HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor	PubMed
	env	HIV-1 gp120-mediated human cell death involves the NMDA receptor complex; antagonists of the NMDA receptor reverse the gp120-mediated effects	PubMed
Tat	tat	HIV-1 Tat induces apoptosis of neurons and neurotoxicity through the activation of both NMDA and non-NMDA receptors	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
Glutamate receptor, ionotropic, N-methyl-D-aspartate 3B	P78352	DLG4	HPRD	PubMed
Glutamate receptor, ionotropic, N-methyl-D-aspartate 3B	Q12879	GRIN2A	HPRD	PubMed
BioGRID:125509	BioGRID:109159	GRIN1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:125509	BioGRID:109160	GRIN2A	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
contributes_to calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
cation channel activity	ISS Inferred from Sequence or Structural Similarity more info
extracellular-glutamate-gated ion channel activity	IEA Inferred from Electronic Annotation more info
glycine binding	ISS Inferred from Sequence or Structural Similarity more info
ionotropic glutamate receptor activity	IEA Inferred from Electronic Annotation more info
neurotransmitter binding	ISS Inferred from Sequence or Structural Similarity more info
neurotransmitter receptor activity	ISS Inferred from Sequence or Structural Similarity more info
receptor activity	IEA Inferred from Electronic Annotation more info
transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
ion transport	IEA Inferred from Electronic Annotation more info
ionotropic glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
protein insertion into membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
regulation of calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
N-methyl-D-aspartate selective glutamate receptor complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
N-methyl-D-aspartate selective glutamate receptor complex	NAS Non-traceable Author Statement more info	PubMed
cell junction	IEA Inferred from Electronic Annotation more info
integral to membrane	IEA Inferred from Electronic Annotation more info
neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info	PubMed
outer membrane-bounded periplasmic space	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info
postsynaptic membrane	IEA Inferred from Electronic Annotation more info
synapse	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: glutamate [NMDA] receptor subunit 3B

Names: glutamate [NMDA] receptor subunit 3B; NMDAR3B; NMDA receptor subunit 3B; N-methyl-D-aspartate receptor subtype 3B; NMDA type glutamate receptor subunit NR3B

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138690.1 → NP_619635.1 glutamate [NMDA] receptor subunit 3B precursor

Status: PROVISIONAL

Source sequence(s)

BK000070, CB243197

Consensus CDS

CCDS32861.1

UniProtKB/Swiss-Prot

O60391

Related

ENSP00000234389, OTTHUMP00000042007, ENST00000234389, OTTHUMT00000103923

Conserved Domains (4) summary

cd00134
Location:478 – 558
Blast Score: 137

PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...

cd06377
Location:23 – 405
Blast Score: 1108

PBP1_iGluR_NMDA_NR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family

pfam00060
Location:576 – 832
Blast Score: 582

Lig_chan; Ligand-gated ion channel

cl15306
Location:676 – 810
Blast Score: 356

PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p5 Primary Assembly

Range

1000437..1009723

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1

Range

769669..782868

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_003403700.1 → XP_003403748.1

Conserved Domains (4) summary

cd00134
Location:573 – 653
Blast Score: 139

PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...

cd06377
Location:163 – 500
Blast Score: 1044

PBP1_iGluR_NMDA_NR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family

pfam00060
Location:671 – 927
Blast Score: 556

Lig_chan; Ligand-gated ion channel

cl15306
Location:771 – 905
Blast Score: 324

PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC004528.1	AAC12680.1
genomic	AX223863.1	CAC69380.1
genomic	CH471139.2	EAW69576.1
mRNA	AY507106.1	AAS87020.1
mRNA	AY507107.1	AAS87021.1
mRNA	BK000070.1	DAA00018.1
mRNA	BK004079.1	DAA04570.1
mRNA	CB243197.1	None
other-genetic	BC156390.1	AAI56391.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O60391.2	GenPept	UniProtKB/Swiss-Prot:O60391
Q5F0I4	GenPept	UniProtKB/TrEMBL:Q5F0I4
Q5F0I5	GenPept	UniProtKB/TrEMBL:Q5F0I5