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    Akap1 A kinase (PRKA) anchor protein 1 [ Mus musculus ]

    Gene ID: 11640, updated on 11-May-2012
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    Summary

    Official Symbol
    Akap1provided by MGI
    Official Full Name
    A kinase (PRKA) anchor protein 1provided by MGI
    Primary source
    MGI:104729
    Locus tag
    RP23-243J8.1
    See related
    Ensembl:ENSMUSG00000018428; Vega:OTTMUSG00000001272
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Akap; AKAP84; C76494; C81186; DAKAP1; AKAP121; S-AKAP84
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    Genomic context

    Location :
    11 C; 11
    Sequence :
    Chromosome: 11; NC_000077.6 (88830792..88864586, complement)
    See Akap1 in Epigenomics, MapViewer

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene Musashi homolog 2 (Drosophila) Neighboring gene ribosomal protein L35A pseudogene Neighboring gene RIKEN cDNA C030037D09 gene Neighboring gene RIKEN cDNA 4930405P13 gene Neighboring gene serine carboxypeptidase 1 Neighboring gene transcription elongation factor B (SIII), polypeptide 2 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. Kim H, et al. Mol Cell, 2011 Nov 18. PMID 22099302.
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    3. AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress. Perrino C, et al. Cardiovasc Res, 2010 Oct 1. PMID 20511238.
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693.
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015.

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. hypoxia induces fission of mitochondrial membranes, dependent on availability of protein AKAP121
      Title: Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia.
    2. Six putative caspase substrates, including five novel proteins (ABCF1, AKAP1, CPE, DOPEY1 and GOPC1) that may be targeted specifically by the initiator caspases 8 and 10 during the early stages of apoptosis, were identified.[caspase 10]
      Title: Genome-wide screening and identification of novel proteolytic cleavage targets of caspase-8 and -10 in vitro.
    3. AKAP121 regulates the response to stress in cardiomyocytes, and therefore AKAP121 downregulation might represent an important event contributing to the development of cardiac dysfunction.
      Title: AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress.
    4. LPL translational inhibition occurs through an RNA-binding complex involving PKA subunits and AKAP121, and this complex can be activated either through traditional PKA activation methods or through the depletion of PKCalpha
      Title: Translational regulation of lipoprotein lipase in adipocytes: depletion of cellular protein kinase Calpha activates binding of the C subunit of protein kinase A to the 3'-untranslated region of the lipoprotein lipase mRNA.
    5. dAKAP1 possesses a single targeting element capable of targeting to both mitochondria and ER, with the ER signal overlapping the mitochondria signal
      Title: A molecular switch for targeting between endoplasmic reticulum (ER) and mitochondria: conversion of a mitochondria-targeting element into an ER-targeting signal in DAKAP1.
    6. AKAP121 levels are regulated post-translationally by the ubiquitin/proteasome pathway.
      Title: Proteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia.
    7. AKAP121 and PKAR2A serve to enhance steroidogenesis by directing the synthesis and activation of STAR at the mitochondria in response to cAMP.
      Title: Mitochondrial A-kinase anchoring protein 121 binds type II protein kinase A and enhances steroidogenic acute regulatory protein-mediated steroidogenesis in MA-10 mouse leydig tumor cells.
    8. AKAP1 is a bifunctional helical element that is required for both ER and mitochondrion targeting.
      Title: A 15-residue bifunctional element in D-AKAP1 is required for both endoplasmic reticulum and mitochondrial targeting.
    9. AKAP121, through its role in enhancing cAMP and tyrosine kinase signaling to distal organelles, is an important regulator in mitochondrial metabolism
      Title: Mitochondrial AKAP121 links cAMP and src signaling to oxidative metabolism.
    10. Purified tubulin binds directly to S-AKAP84 but not to a deletion mutant lacking the mitochondrial targeting domain (MT) at residues 1-30.
      Title: A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs.
    Submit: New GeneRIF Correction See all (11)
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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:198048 BioGRID:112373 SIAH2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:198048 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
      G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein complex scaffold ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein phosphatase 2B binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    negative regulation of NFAT protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    lipid particle ISO
    Inferred from Sequence Orthology
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial crista ISO
    Inferred from Sequence Orthology
    more info
    		  
    mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
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    General protein information

    Preferred Names
    A-kinase anchor protein 1, mitochondrial
    Names
    A-kinase anchor protein 1, mitochondrial
    PRKA1
    S-AKAP
    D-AKAP-1
    spermatid A-kinase anchor protein
    protein kinase A-anchoring protein 1
    a kinase anchor protein 1, mitochondrial
    dual specificity A-kinase-anchoring protein 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042541.1 → NP_001036006.1  A-kinase anchor protein 1, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      AK020371, AK132749, AL596180, CJ167452
      Consensus CDS
      CCDS25229.1
      UniProtKB/Swiss-Prot
      O08715
      UniProtKB/TrEMBL
      Q9CTT7
      Related
      ENSMUSP00000018572, OTTMUSP00000001249, ENSMUST00000018572, OTTMUST00000002533
      Conserved Domains (3) summary
      cd00105
      Location:565 – 625
      Blast Score: 144
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd04508
      Location:718 – 763
      Blast Score: 123
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:661 – 777
      Blast Score: 232
      TUDOR; Tudor domain

    2. NM_009648.2 → NP_033778.2  A-kinase anchor protein 1, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      AK020371, AK132749, AL596180
      Consensus CDS
      CCDS25229.1
      UniProtKB/Swiss-Prot
      O08715
      UniProtKB/TrEMBL
      Q9CTT7
      Related
      ENSMUSP00000103536, OTTMUSP00000001248, ENSMUST00000107903, OTTMUST00000002532
      Conserved Domains (3) summary
      cd00105
      Location:565 – 625
      Blast Score: 144
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd04508
      Location:718 – 763
      Blast Score: 123
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:661 – 777
      Blast Score: 232
      TUDOR; Tudor domain

    RefSeqs of Annotated Genomes: Build 38.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38 C57BL/6J

      Range
      88830792..88864586, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38 NOD/ShiLtJ

    Genomic

    1. NT_187003.1 Reference GRCm38 NOD/ShiLtJ

      Range
      1976122..2009712, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000033.1 Alternate Mm_Celera

      Range
      98443444..98477088, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AL596180.8 CAI24699.1
    genomic CH466556.1 EDL15856.1 mixed
      EDL15857.1 mixed
    mRNA AK020371.1 BAB32084.2 C57BL/6J
    mRNA AK076216.1 None C57BL/6J
    mRNA AK132749.1 None C57BL/6J
    mRNA AK183703.1 None
    mRNA AK196354.1 None
    mRNA BC065135.1 None C57BL/6
    mRNA CJ167452.1 None
    mRNA U84389.1 AAC27100.1
    mRNA U95145.1 AAB53740.1 BALB/c
    mRNA U95146.1 AAB53741.1 BALB/c
    other-genetic BC152925.1 AAI52926.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08715.4 GenPept UniProtKB/Swiss-Prot:O08715
    Q9CTT7 GenPept UniProtKB/TrEMBL:Q9CTT7
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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