CKS2 CDC28 protein kinase regulatory subunit 2 [Homo sapiens] - Gene

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Summary

Official Symbol: CKS2provided by HGNC
Official Full Name: CDC28 protein kinase regulatory subunit 2provided by HGNC
Primary source: HGNC:2000
Locus tag: RP11-8C21.2
See related: Ensembl:ENSG00000123975; HPRD:00300; MIM:116901; Vega:OTTHUMG00000020180
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CKSHS2
Summary: CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 9q22

Sequence :: Chromosome: 9; NC_000009.11 (91926113..91931618)

See CKS2 in Epigenomics, MapViewer

Chromosome 9 - NC_000009.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study calculated DeltaCt values of CKS2 and LEPR and found that their differential expression (C-L index) was significantly higher in grade I than in grade II or III meningiomas.
Title: DNA microarray analysis identifies CKS2 and LEPR as potential markers of meningioma recurrence.
Overexpression of Cks1 or Cks2 in human mammary epithelial and breast cancer-derived cells, as well as in other cell types, leads to override of the intra-S-phase checkpoint.
Title: Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins.
The Cks2 gene may have potential as a biomarker for predicting superficial bladder cancer progression to muscle-invasive cancer.
Title: Cyclin-dependent kinase-associated protein Cks2 is associated with bladder cancer progression.
CKS2 is one of the gastric cancer-related genes that correlates with biological aggressiveness and poor prognosis of gastric cancer.
Title: Clinicopathological and biological significance of CDC28 protein kinase regulatory subunit 2 overexpression in human gastric cancer.
the involvement CKS2 gene expression in bladder cancer tumorgenesis
Title: Expression and biological-clinical significance of hTR, hTERT and CKS2 in washing fluids of patients with bladder cancer.
Overexpression of Cks1 and Cks2 is associated with the aggressive tumour behaviours of hepatocellular carcinoma.
Title: Clinical significance and expression of cyclin kinase subunits 1 and 2 in hepatocellular carcinoma.
Results suggest that the cell cycle regulator CKS2 might be deeply involved in gastric cancer progression.
Title: Upregulation of the cycline kinase subunit CKS2 increases cell proliferation rate in gastric cancer.
Data show that cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells.
Title: Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells.
Elevated expression of Cks1 may contribute to prostate tumorigenesis by promoting proliferation, anchorage-independent growth and migration of the cells, and elevated expression of Cks2 by protecting cells from undergoing programmed cell death.
Title: Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death.
p53, rather than its homologues p63 and p73, may contribute to control of the first metaphase/anaphase transition of mammalian meiosis by downregulation of Cks2 expression
Title: Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001818.1	NP_114172.1	CCNB1	BIND	PubMed	Cks2 interacts with Cyclin B1.
NP_001818.1	NP_036423.3	ESPL1	BIND	PubMed	Separase interacts with Cks2.
P33552	P06493	CDK1	HPRD	PubMed
P33552	P61024	CKS1B	HPRD	PubMed
P33552	P33552	CKS2	HPRD	PubMed
P33552	P68104	EEF1A1	HPRD	PubMed
P33552	Q9Y3Q8	TSC22D4	HPRD	PubMed
P33552	Q13432	UNC119	HPRD	PubMed
BioGRID:107583	BioGRID:114417	CCNA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107583	BioGRID:107331	CCNA2	BioGRID	PubMed	Biochemical Activity
BioGRID:107583	BioGRID:107332	CCNB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107583	BioGRID:114581	CCNB2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107583	BioGRID:116312	CDC37	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107583	BioGRID:107420	CDK1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107583	BioGRID:107452	CDK2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107583	BioGRID:107583	CKS2	BioGRID	PubMed	Co-crystal Structure
BioGRID:107583	BioGRID:198624	Cdk1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107583	BioGRID:108237	EEF1A1	BioGRID	PubMed	Two-hybrid
BioGRID:107583	BioGRID:109552	HSP90AA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107583	BioGRID:110137	LDHB	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107583	BioGRID:112620	SSBP1	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:107583	BioGRID:123563	TSC22D4	BioGRID	PubMed	Two-hybrid
BioGRID:107583	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107583	BioGRID:114548	UNC119	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
cyclin-dependent protein kinase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cell cycle	NAS Non-traceable Author Statement more info	PubMed
cell division	IEA Inferred from Electronic Annotation more info
cell proliferation	TAS Traceable Author Statement more info	PubMed
meiosis I	IEA Inferred from Electronic Annotation more info
phosphatidylinositol-mediated signaling	NAS Non-traceable Author Statement more info	PubMed
regulation of cyclin-dependent protein kinase activity	TAS Traceable Author Statement more info	PubMed
spindle organization	NAS Non-traceable Author Statement more info	PubMed

General protein information

Preferred Names: cyclin-dependent kinases regulatory subunit 2

Names: cyclin-dependent kinases regulatory subunit 2; CKS-2; CDC28 protein kinase 2; CKS1(S. cerevisiae Cdc28/Cdc2 kinase subunit) homolog-2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001827.1 → NP_001818.1 cyclin-dependent kinases regulatory subunit 2

Status: REVIEWED

Source sequence(s)

X54942

Consensus CDS

CCDS6682.1

UniProtKB/Swiss-Prot

P33552

UniProtKB/TrEMBL

Q6FGI9

Related

ENSP00000364976, OTTHUMP00000021616, ENST00000314355, OTTHUMT00000052988

Conserved Domains (1) summary

cl03104
Location:5 – 74
Blast Score: 318

CKS; Cyclin-dependent kinase regulatory subunit

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000009.11 Reference GRCh37.p5 Primary Assembly

Range

91926113..91931618

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000141.1 Alternate HuRef

Range

61759015..61764519

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF506708.1	AAM22232.1
genomic	AL160054.14	CAI41365.1
genomic	CH471089.1	EAW62762.1
genomic	CS185526.1	CAJ42707.1
genomic	HI519560.1	CBX54361.1
mRNA	BC006458.1	AAH06458.1
mRNA	BC020345.1	None
mRNA	BT006630.1	AAP35276.1
mRNA	CR407630.1	CAG28558.1
mRNA	CR542118.1	CAG46915.1
mRNA	X54942.1	CAA38703.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P33552.1	GenPept	UniProtKB/Swiss-Prot:P33552
Q6FGI9	GenPept	UniProtKB/TrEMBL:Q6FGI9
Q6LET5	GenPept	UniProtKB/TrEMBL:Q6LET5