PANX3 pannexin 3 [Homo sapiens] - Gene

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Summary

Official Symbol: PANX3provided by HGNC
Official Full Name: pannexin 3provided by HGNC
Primary source: HGNC:20573
See related: Ensembl:ENSG00000154143; HPRD:16334; MIM:608422; Vega:OTTHUMG00000165925
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PX3
Summary: The protein encoded by this gene belongs to the innexin family. Innexin family members are known to be the structural components of gap junctions. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 11q24.2

Sequence :: Chromosome: 11; NC_000011.9 (124481453..124490252)

See PANX3 in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Panx3 functions to switch the chondrocyte cell fate from proliferation to differentiation by regulating the intracellular ATP/cAMP levels
Title: Pannexin 3 regulates intracellular ATP/cAMP levels and promotes chondrocyte differentiation.
although Panx1 and Panx3 share a common endoplasmic reticulum to Golgi secretory pathway to Cx43, their ultimate cell surface residency appears to be independent of cell contacts and the need for intact microtubules
Title: Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions.
These studies show that Panx1 and Panx3 have many characteristics that are distinct from Cx43 and that these proteins probably play an important biological role as single membrane channels.
Title: Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:125498	BioGRID:107076	BCL6		BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
gap junction hemi-channel activity	ISS Inferred from Sequence or Structural Similarity more info
ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cell-cell signaling	IEA Inferred from Electronic Annotation more info
ion transport	IEA Inferred from Electronic Annotation more info
protein hexamerization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
cell junction	IEA Inferred from Electronic Annotation more info
gap junction	IEA Inferred from Electronic Annotation more info
integral to membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: pannexin-3

Names: pannexin-3; gap junction protein pannexin 3

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_052959.2 → NP_443191.1 pannexin-3

Status: REVIEWED

Source sequence(s)

AA456140, AF406650

Consensus CDS

CCDS8447.1

UniProtKB/Swiss-Prot

Q96QZ0

Related

ENSP00000284288, OTTHUMP00000231522, ENST00000284288, OTTHUMT00000387064

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p5 Primary Assembly

Range

124481453..124490252

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

120423913..120432711

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AP001524.4 (86527..95326)	None
genomic	CH471065.1	EAW67588.1
mRNA	AA456140.1	None
mRNA	AF406650.1	AAK95655.1
other-genetic	BC152944.1	AAI52945.1