CKS1B CDC28 protein kinase regulatory subunit 1B [Homo sapiens] - Gene

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Summary

Official Symbol: CKS1Bprovided by HGNC
Official Full Name: CDC28 protein kinase regulatory subunit 1Bprovided by HGNC
Primary source: HGNC:19083
Locus tag: RP11-307C12.6
See related: Ensembl:ENSG00000173207; HPRD:00299; MIM:116900; Vega:OTTHUMG00000037413
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CKS1; ckshs1; PNAS-16; PNAS-18
Summary: CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]

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Genomic context

Location :: 1q21.2

Sequence :: Chromosome: 1; NC_000001.10 (154947118..154951725)

See CKS1B in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In hepatoma cells, Cks1 controlled IL-8 expression by targeting the NF-kappaB regulator IkappaBalpha, which led to NF-kappaB activation, via a p27-independent regulation of IkappaB kinase complex components.
Title: Cell-cycle regulator Cks1 promotes hepatocellular carcinoma by supporting NF-κB-dependent expression of interleukin-8.
Over-expression of CKS1B activates both MEK/ERK and JAK/STAT3 signaling pathways and promotes myeloma cell drug-resistance.
Title: Over-expression of CKS1B activates both MEK/ERK and JAK/STAT3 signaling pathways and promotes myeloma cell drug-resistance.
A significant CKS1B overexpression was observed in oral squamous cell carcinoma and lymph node metastases samples than in oral lichen planus or oral leukoplakia.
Title: CDC28 protein kinase regulatory subunit 1B (CKS1B) expression and genetic status analysis in oral squamous cell carcinoma.
In addition to having a pivotal role in the up-regulation of IL-2 and IL-2RA gene expression, IKK controls the expression of cyclin D3, cyclin E and CDK2, and the stability SKP2 and its co-factor CKS1B, through mechanisms independent of IL-2.
Title: In CD28-costimulated human naïve CD4+ T cells, I-κB kinase controls the expression of cell cycle regulatory proteins via interleukin-2-independent mechanisms.
Association between CKS1B protein overexpression and both polysomy and amplification was demonstrated in cutaneous squamous cell carcinoma
Title: CKS1B amplification is a frequent event in cutaneous squamous cell carcinoma with aggressive clinical behaviour.
CKS-1B is commonly expressed in mantle cell lymphoma, particularly in aggressive histologic variants, and may be involved in pathogenesis.
Title: Differential expression of CKS-1B in typical and blastoid variants of mantle cell lymphoma.
Data report that endogenous cyclin B1-Cdk1 is recruited in a Cks-dependent manner to checkpoint-inhibited, phosphorylated APC/C in prometaphase independently of Cdc20 or the cyclin B1 D box.
Title: The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
CKS1B overexpression implicates clinical aggressiveness of hepatocellular carcinomas but not p27(Kip1) protein turnover.
Title: CKS1B overexpression implicates clinical aggressiveness of hepatocellular carcinomas but not p27(Kip1) protein turnover: an independent prognosticator with potential p27 (Kip1)-independent oncogenic attributes?
Data show that mtSSB bound both CKS1 and CKS2 and underwent CDK-dependent phosphorylation.
Title: CKS proteins protect mitochondrial genome integrity by interacting with mitochondrial single-stranded DNA-binding protein.

Submit: New GeneRIF Correction See all (25)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P61024	P24941	CDK2	HPRD	PubMed
P61024	P46527	CDKN1B	HPRD	PubMed
P61024	P61024	CKS1B	HPRD	PubMed
P61024	P33552	CKS2	HPRD	PubMed
P61024	Q13309	SKP2	HPRD	PubMed
BioGRID:107582	BioGRID:107331	CCNA2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:107582	BioGRID:107431	CDC27	BioGRID	PubMed	Reconstituted Complex
BioGRID:107582	BioGRID:107452	CDK2	BioGRID	PubMed	Affinity Capture-Western; Co-crystal Structure
BioGRID:107582	BioGRID:107461	CDKN1B	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:107582	BioGRID:116176	COPS6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107582	BioGRID:198624	Cdk1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107582	BioGRID:108176	DUSP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107582	BioGRID:111687	PSMD9	BioGRID	PubMed	FRET
BioGRID:107582	BioGRID:112393	SKP2	BioGRID	PubMed	Affinity Capture-Western; FRET; Reconstituted Complex

Function	Evidence Code	Pubs
cyclin-dependent protein kinase regulator activity	IEA Inferred from Electronic Annotation more info
kinase activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
G1 phase of mitotic cell cycle	TAS Traceable Author Statement more info
G1/S transition of mitotic cell cycle	TAS Traceable Author Statement more info
S phase of mitotic cell cycle	TAS Traceable Author Statement more info
cell cycle	IEA Inferred from Electronic Annotation more info
cell division	IEA Inferred from Electronic Annotation more info
cell proliferation	TAS Traceable Author Statement more info	PubMed
mitotic cell cycle	TAS Traceable Author Statement more info
regulation of cyclin-dependent protein kinase activity	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
nucleoplasm	TAS Traceable Author Statement more info

General protein information

Preferred Names: cyclin-dependent kinases regulatory subunit 1

Names: cyclin-dependent kinases regulatory subunit 1; CKS-1; PNAS-143; CDC28 protein kinase 1; CDC28 protein kinase 1B; CDC2-associated protein CKS1; cell division control protein CKS1; NB4 apoptosis/differentiation related protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001826.2 → NP_001817.1 cyclin-dependent kinases regulatory subunit 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the protein-coding variant.

Source sequence(s)

BQ883992, CN347951

Consensus CDS

CCDS1077.1

UniProtKB/Swiss-Prot

P61024

UniProtKB/TrEMBL

Q5T178

Related

ENSP00000311083, OTTHUMP00000035541, ENST00000308987, OTTHUMT00000091078

Conserved Domains (1) summary

cl03104
Location:5 – 66
Blast Score: 291

CKS; Cyclin-dependent kinase regulatory subunit

RNA

NR_024163.1 RNA Sequence

Description

Transcript Variant: This variant (2) uses a different splice site at the 3' end of the first exon compared to variant 1. There is no evidence that this variant encodes a protein.

Source sequence(s)

BQ883992, CB161621, CN347951

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

154947118..154951725

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

126308863..126313470

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL451085.20	CAI13255.1
		CAI13256.1
		CAI13257.1
genomic	CH471121.2	EAW53160.1
		EAW53161.1
		EAW53162.1
		EAW53163.1
		EAW53164.1
		EAW53165.1
		EAW53166.1
mRNA	AF274941.1	AAK07518.1
mRNA	AF274943.1	AAK07520.1
mRNA	AF279897.1	AAK07553.1
mRNA	AK307066.1	None
mRNA	AK311769.1	BAG34712.1
mRNA	BC007751.2	AAH07751.1
mRNA	BC015629.2	AAH15629.1
mRNA	BC070319.1	AAH70319.1
mRNA	BC070320.1	AAH70320.1
mRNA	BQ883992.1	None
mRNA	BT007196.1	AAP35860.1
mRNA	CB161621.1	None
mRNA	CN347951.1	None
mRNA	X54941.1	CAA38702.1
other-genetic	DQ890700.2	ABM81626.1
other-genetic	DQ892972.2	ABM83898.1
other-genetic	DQ893884.2	ABM84810.1
other-genetic	DQ895958.2	ABM86884.1
other-genetic	EU176486.1	ABW03287.1
other-genetic	EU176487.1	ABW03288.1

Protein Accession	Links
Protein Accession	GenePept Link	UniProtKB Link
P61024.1	GenPept	UniProtKB/Swiss-Prot:P61024
Q5T178	GenPept	UniProtKB/TrEMBL:Q5T178
Q9BZU3	GenPept	UniProtKB/TrEMBL:Q9BZU3