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Agtr2 angiotensin II receptor, type 2 [ Mus musculus (house mouse) ]

Gene ID: 11609, updated on 21-May-2016
Official Symbol
Agtr2provided by MGI
Official Full Name
angiotensin II receptor, type 2provided by MGI
Primary source
MGI:MGI:87966
See related
Ensembl:ENSMUSG00000068122 Vega:OTTMUSG00000017210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI316812; AW107640
Orthologs
Location:
X A2; X 16.71 cM
Exon count:
3
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) X NC_000086.7 (21484549..21488833)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (21061752..21065957)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6938 Neighboring gene nucleolar and coiled-body phosphoprotein 1 pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 14

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
angiotensin type II receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
angiotensin type II receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
angiotensin type II receptor activity ISO
Inferred from Sequence Orthology
more info
 
peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger IDA
Inferred from Direct Assay
more info
PubMed 
aldosterone secretion ISO
Inferred from Sequence Orthology
more info
 
brain renin-angiotensin system IDA
Inferred from Direct Assay
more info
PubMed 
cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cellular response to dexamethasone stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
cerebellar cortex development ISO
Inferred from Sequence Orthology
more info
 
dopamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
exploration behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
kidney morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of icosanoid secretion ISO
Inferred from Sequence Orthology
more info
 
NOT negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of metanephric glomerulus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of renal sodium excretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vasodilation ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of metanephros size IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of systemic arterial blood pressure by circulatory renin-angiotensin IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription factor import into nucleus ISO
Inferred from Sequence Orthology
more info
 
regulation of vasodilation IEA
Inferred from Electronic Annotation
more info
 
renin-angiotensin regulation of aldosterone production ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
vasodilation by angiotensin involved in regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
type-2 angiotensin II receptor
Names
AT2 receptor
angiotensin II type-2 receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007429.5NP_031455.1  type-2 angiotensin II receptor

    See identical proteins and their annotated locations for NP_031455.1

    Status: VALIDATED

    Source sequence(s)
    AK086334, AK140941
    Consensus CDS
    CCDS40889.1
    UniProtKB/Swiss-Prot
    P35374
    UniProtKB/TrEMBL
    Q3US12
    Related
    ENSMUSP00000086592, OTTMUSP00000018718, ENSMUST00000089188, OTTMUST00000041678
    Conserved Domains (1) summary
    pfam00001
    Location:68318
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p3 C57BL/6J

    Range
    21484549..21488833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527555.1XP_006527618.1  

    Conserved Domains (1) summary
    pfam00001
    Location:98348
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate Mm_Celera

Genomic

  1. AC_000042.1 Alternate Mm_Celera

    Range
    19607385..19611595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)