Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Agtprovided by MGI
Official Full Name: angiotensinogen (serpin peptidase inhibitor, clade A, member 8)provided by MGI
Primary source: MGI:87963
See related: Ensembl:ENSMUSG00000031980
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AngI; AngII; Aogen; AI265500; Serpina8

Genomic context

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Location :: 8 E2; 8 72.81 cM

Sequence :: Chromosome: 8; NC_000074.6 (124556587..124569707, complement)

See Agt in Epigenomics, MapViewer

Chromosome 8 - NC_000074.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Severe acute pancreatitis is associated with upregulation of the ACE2-angiotensin-(1-7)-Mas axis and promotes increased circulating angiotensin-(1-7).
Title: Severe acute pancreatitis is associated with upregulation of the ACE2-angiotensin-(1-7)-Mas axis and promotes increased circulating angiotensin-(1-7).
Angiotensin II drives the production of tumor-promoting macrophages.
Title: Angiotensin II drives the production of tumor-promoting macrophages.
Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II.
Title: Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II.
Cross-talk between inflammation and angiotensin II: studies based on direct transfection of cardiomyocytes with AT1R and AT2R cDNA.
Title: Cross-talk between inflammation and angiotensin II: studies based on direct transfection of cardiomyocytes with AT1R and AT2R cDNA.
Ang II participates in wound repair
Title: [The change of angiotensin II production and its receptor expression during wound healing: possible role of angiotensin II in wound healing].
Overall, these data suggest that Nox2 plays a relatively prominent role in mediating Ang II-induced oxidative stress and cerebral endothelial dysfunction, with a minor role for Nox1.
Title: Role of Nox isoforms in angiotensin II-induced oxidative stress and endothelial dysfunction in brain.
endothelial Gab1 deletion accelerates AngII-dependent vascular inflammation and atherosclerosis on ApoE-null background presumably in association with downregulation of KLF2 and KLF4.
Title: Endothelial Gab1 deletion accelerates angiotensin II-dependent vascular inflammation and atherosclerosis in apolipoprotein E knockout mice.
The enhanced expression of bone renin and angiotensin II plays an important role in the pathology of age-related osteoporosis.
Title: Involvement of the skeletal renin-angiotensin system in age-related osteoporosis of ageing mice.
Ang II stimulates vascular endocannabinoid formation, which attenuates its vasoconstrictor effect, suggesting that endocannabinoid release from the vascular wall and CB(1)R activation reduces the vasoconstrictor and hypertensive effects of Ang II.
Title: Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors.
a critical role for H(2)O(2) in angiotensin-II signaling to the endothelial cytoskeleton in a novel pathway that is critically dependent on MARCKS, Rac1, and c-Abl.
Title: Angiotensin-II and MARCKS: a hydrogen peroxide- and RAC1-dependent signaling pathway in vascular endothelium.

Submit: New GeneRIF Correction See all (109)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (3) 1 citation
Targeted (knock-in) (1) 1 citation

Pathways from BioSystems

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ACE Inhibitor Pathway, organism-specific biosystem (from WikiPathways)
ACE Inhibitor Pathway, organism-specific biosystemThe renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representatio...
Adipogenesis, organism-specific biosystem (from WikiPathways)
Adipogenesis, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
G alpha (q) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystem (from REACTOME)
Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted inter...
PPARA Activates Gene Expression, organism-specific biosystem (from REACTOME)
PPARA Activates Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
Peptide hormone metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
Peptide ligand-binding receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Renin-angiotensin system, organism-specific biosystem (from KEGG)
Renin-angiotensin system, organism-specific biosystem
Renin-angiotensin system
Renin-angiotensin system, conserved biosystem (from KEGG)
Renin-angiotensin system, conserved biosystem
Renin-angiotensin system
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

PMC162290P1 (e-PCR)
- UniSTS:271471

AI265500 (e-PCR)
- UniSTS:179845

Agt (e-PCR), detects polymorphism
- UniSTS:532414

RH65641 (e-PCR)
- UniSTS:18170

Agt (e-PCR), detects polymorphism
- UniSTS:141052

Homology

Homologs of the Agt gene: The Agt gene is conserved in human, chimpanzee, Rhesus monkey, dog, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
acetyltransferase activator activity	ISO Inferred from Sequence Orthology more info
angiotensin receptor binding	ISO Inferred from Sequence Orthology more info
hormone activity	ISO Inferred from Sequence Orthology more info
serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
type 1 angiotensin receptor binding	IDA Inferred from Direct Assay more info	PubMed
type 1 angiotensin receptor binding	ISO Inferred from Sequence Orthology more info
type 2 angiotensin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
type 2 angiotensin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
G-protein coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
activation of NF-kappaB-inducing kinase activity	IDA Inferred from Direct Assay more info	PubMed
activation of phospholipase C activity	ISO Inferred from Sequence Orthology more info
angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure	IDA Inferred from Direct Assay more info	PubMed
angiotensin-mediated drinking behavior	ISO Inferred from Sequence Orthology more info
artery smooth muscle contraction	ISO Inferred from Sequence Orthology more info
astrocyte activation	IMP Inferred from Mutant Phenotype more info	PubMed
blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
brain renin-angiotensin system	IDA Inferred from Direct Assay more info	PubMed
branching involved in ureteric bud morphogenesis	IDA Inferred from Direct Assay more info	PubMed
NOT branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
catenin import into nucleus	ISO Inferred from Sequence Orthology more info
cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
cellular sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
cytokine secretion	ISO Inferred from Sequence Orthology more info
drinking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
establishment of blood-nerve barrier	IMP Inferred from Mutant Phenotype more info	PubMed
excretion	IMP Inferred from Mutant Phenotype more info	PubMed
extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
fibroblast proliferation	ISO Inferred from Sequence Orthology more info
hormone metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
induction of apoptosis	ISO Inferred from Sequence Orthology more info
kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
kidney development	ISO Inferred from Sequence Orthology more info
negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
negative regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of neurotrophin TRK receptor signaling pathway	ISO Inferred from Sequence Orthology more info
negative regulation of tissue remodeling	ISO Inferred from Sequence Orthology more info
ovarian follicle rupture	IMP Inferred from Mutant Phenotype more info	PubMed
peristalsis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of activation of JAK2 kinase activity	ISO Inferred from Sequence Orthology more info
positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
positive regulation of branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
positive regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
positive regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
positive regulation of cellular protein metabolic process	ISO Inferred from Sequence Orthology more info
positive regulation of cholesterol esterification	ISO Inferred from Sequence Orthology more info
positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of extracellular matrix constituent secretion	ISO Inferred from Sequence Orthology more info
positive regulation of fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of organ growth	IDA Inferred from Direct Assay more info	PubMed
positive regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of phosphatidylinositol 3-kinase cascade	ISO Inferred from Sequence Orthology more info
positive regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
positive regulation of renal sodium excretion	ISO Inferred from Sequence Orthology more info
positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
regulation of inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
regulation of norepinephrine secretion	ISO Inferred from Sequence Orthology more info
regulation of proteolysis	IBA Inferred from Biological aspect of Ancestor more info
regulation of renal output by angiotensin	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of renal sodium excretion	ISO Inferred from Sequence Orthology more info
regulation of systemic arterial blood pressure by circulatory renin-angiotensin	IMP Inferred from Mutant Phenotype more info	PubMed
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
renin-angiotensin regulation of aldosterone production	IMP Inferred from Mutant Phenotype more info	PubMed
renin-angiotensin regulation of aldosterone production	ISO Inferred from Sequence Orthology more info
response to cold	IMP Inferred from Mutant Phenotype more info	PubMed
response to muscle activity involved in regulation of muscle adaptation	ISO Inferred from Sequence Orthology more info
response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
smooth muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
smooth muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
uterine smooth muscle contraction	ISO Inferred from Sequence Orthology more info
vasoconstriction	ISO Inferred from Sequence Orthology more info
vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
cytoplasmic part	ISO Inferred from Sequence Orthology more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: angiotensinogen

Names: angiotensinogen; serpin A8; angiotensin I; angiotensin ll

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007428.3 → NP_031454.3 angiotensinogen

Status: VALIDATED

Source sequence(s)

AK139179, BB869708, BM899343

Consensus CDS

CCDS40513.1

UniProtKB/TrEMBL

Q3UTR7

Related

ENSMUSP00000066488, ENSMUST00000063278

Conserved Domains (1) summary

cl00137
Location:102 – 478
Blast Score: 1025

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000074.6 Reference GRCm38.p1 C57BL/6J

Range

124556587..124569707, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000030.1 Alternate Mm_Celera

Range

128860995..128873954, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01075446.1 (50787..63746)	None
genomic	AC126930.4 (13991..27087)	None
genomic	AF045883.1	None	BALB/c
genomic	AF045884.1	AAC01765.1	BALB/c
genomic	AF045885.1	AAC01765.1	BALB/c
genomic	AF045886.1	AAC01765.1	BALB/c
genomic	AF045887.1	AAC01765.1	BALB/c
genomic	CH466525.1	EDL11771.1	mixed
mRNA	AK005354.1	None	C57BL/6J
mRNA	AK018763.1	None	C57BL/6J
mRNA	AK139179.1	BAE23913.1	C57BL/6J
mRNA	BB869708.1	None	C57BL/6
mRNA	BC019496.1	AAH19496.1	FVB/N
mRNA	BC028877.1	AAH28877.1	FVB/N
mRNA	BC054387.1	AAH54387.1	FVB/N
mRNA	BM899343.1	None	C57BL/6
other-genetic	BC156111.1	AAI56112.1
other-genetic	BC156904.1	AAI56905.1