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Agrp agouti related neuropeptide [ Mus musculus (house mouse) ]

Gene ID: 11604, updated on 28-May-2016
Official Symbol
Agrpprovided by MGI
Official Full Name
agouti related neuropeptideprovided by MGI
Primary source
MGI:MGI:892013
See related
Ensembl:ENSMUSG00000005705 Vega:OTTMUSG00000050255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Art; Agrt
Summary
This gene encodes a protein that regulates feeding behavior and plays a key role in the control of body weight. The encoded protein acts as an antagonist of melanocortin receptor signaling. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2012]
Orthologs
Location:
8; 8 D1-D2
Exon count:
6
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (105566695..105579845, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (108090598..108092198, complement)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene hydroxysteroid 11-beta dehydrogenase 2 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit D1 Neighboring gene predicted gene, 39237 Neighboring gene family with sequence similarity 65, member A Neighboring gene microRNA 1966 Neighboring gene predicted gene 5914 Neighboring gene CCCTC-binding factor

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
    Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
    Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...

Markers

Potential readthrough

Included gene: Gm5914

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
neuropeptide hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
neuropeptide hormone activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adult feeding behavior IDA
Inferred from Direct Assay
more info
PubMed 
eating behavior ISO
Inferred from Sequence Orthology
more info
 
hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
 
regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi lumen ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
agouti-related protein
Names
agouti related protein
orexigenic neuropeptide

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271806.1NP_001258735.1  agouti-related protein precursor

    See identical proteins and their annotated locations for NP_001258735.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC151573, AK138796, BC079902
    Consensus CDS
    CCDS22605.1
    UniProtKB/Swiss-Prot
    P56473
    UniProtKB/TrEMBL
    Q3UU47
    Related
    ENSMUSP00000141783, OTTMUSP00000068842, ENSMUST00000194654, OTTMUST00000127666
    Conserved Domains (1) summary
    smart00792
    Location:1121
    Agouti; Agouti protein
  2. NM_007427.3NP_031453.1  agouti-related protein precursor

    See identical proteins and their annotated locations for NP_031453.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK138796, BC079902, CO044337
    Consensus CDS
    CCDS22605.1
    UniProtKB/Swiss-Prot
    P56473
    UniProtKB/TrEMBL
    Q3UU47
    Related
    ENSMUSP00000005849, OTTMUSP00000068840, ENSMUST00000005849, OTTMUST00000127664
    Conserved Domains (1) summary
    smart00792
    Location:1121
    Agouti; Agouti protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

    Range
    105566695..105579845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    109789927..109803342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)