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    RNF166 ring finger protein 166 [ Homo sapiens ]

    Gene ID: 115992, updated on 11-May-2012

    Summary

    Official Symbol
    RNF166provided by HGNC
    Official Full Name
    ring finger protein 166provided by HGNC
    Primary source
    HGNC:28856
    See related
    Ensembl:ENSG00000158717; HPRD:15260; Vega:OTTHUMG00000137863
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MGC2647; MGC14381

    Genomic context

    Location :
    16q24.3
    Sequence :
    Chromosome: 16; NC_000016.9 (88762903..88772829, complement)
    See RNF166 in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene mevalonate (diphospho) decarboxylase Neighboring gene uncharacterized LOC197187 Neighboring gene snail homolog 3 (Drosophila) Neighboring gene cytosolic thiouridylase subunit 2 homolog (S. pombe) Neighboring gene microRNA 4722 Neighboring gene piezo-type mechanosensitive ion channel component 1

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:125465 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125465 BioGRID:113169 UBE2D1    BioGRID  PubMed Two-hybrid 
    BioGRID:125465 BioGRID:113170 UBE2D2    BioGRID  PubMed Two-hybrid 
    BioGRID:125465 BioGRID:113171 UBE2D3    BioGRID  PubMed Two-hybrid 
    BioGRID:125465 BioGRID:119641 UBE2D4    BioGRID  PubMed Two-hybrid 
    BioGRID:125465 BioGRID:113172 UBE2E1    BioGRID  PubMed Two-hybrid 
    BioGRID:125465 BioGRID:113173 UBE2E2    BioGRID  PubMed Two-hybrid 
    BioGRID:125465 BioGRID:115740 UBE2E3    BioGRID  PubMed Two-hybrid 
    BioGRID:125465 BioGRID:113176 UBE2H    BioGRID  PubMed Two-hybrid 
    BioGRID:125465 BioGRID:127156 UBE2U    BioGRID  PubMed Two-hybrid 
    BioGRID:125465 BioGRID:120572 UBE2W    BioGRID  PubMed Two-hybrid 
    BioGRID:125465 BioGRID:122419 UBE2Z    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    RING finger protein 166
    Names
    RING finger protein 166

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171815.1NP_001165286.1  RING finger protein 166 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment of the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC138028, AI800509, AK057106, BI911983
      Consensus CDS
      CCDS54057.1
      UniProtKB/TrEMBL
      H3BTU8
      UniProtKB/Swiss-Prot
      Q96A37
      Related
      ENSP00000457336, OTTHUMP00000250451, ENST00000567844, OTTHUMT00000423211
      Conserved Domains (1) summary
      pfam05605
      Location:66106
      Blast Score: 85
      Di19; Drought induced 19 protein (Di19)
    2. NM_001171816.1NP_001165287.1  RING finger protein 166 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC138028, AI800509, AK057106
      Consensus CDS
      CCDS54056.1
      UniProtKB/Swiss-Prot
      Q96A37
      Related
      ENSP00000440454, OTTHUMP00000250450, ENST00000541206, OTTHUMT00000423210
      Conserved Domains (1) summary
      pfam05605
      Location:3878
      Blast Score: 83
      Di19; Drought induced 19 protein (Di19)
    3. NM_178841.3NP_849163.1  RING finger protein 166 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC138028, AI800509, AK057106, BC013948, DA376321
      Consensus CDS
      CCDS10969.1
      UniProtKB/Swiss-Prot
      Q96A37
      Related
      ENSP00000326095, OTTHUMP00000175194, ENST00000312838, OTTHUMT00000269544
      Conserved Domains (3) summary
      cd00162
      Location:3276
      Blast Score: 124
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam05605
      Location:147187
      Blast Score: 84
      Di19; Drought induced 19 protein (Di19)
      pfam13923
      Location:3073
      Blast Score: 107
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      88762903..88772829, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      74457276..74467225, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC138028.1 (72271..82178) None
    genomic CH471184.2 EAW66781.1
      EAW66782.1
      EAW66783.1
      EAW66784.1
      EAW66785.1
      EAW66786.1
    mRNA AI800509.1 None
    mRNA AK026860.1 None
    mRNA AK057106.1 BAG51865.1
    mRNA AK057201.1 BAB71380.1
    mRNA AK290920.1 BAF83609.1
    mRNA BC013948.2 AAH13948.1
    mRNA BC017226.1 AAH17226.1
    mRNA BI911983.1 None
    mRNA DA376321.1 None
    other-genetic HQ258016.1 ADR82770.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96A37.1 GenPept UniProtKB/Swiss-Prot:Q96A37

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