ALPK2 alpha-kinase 2 [Homo sapiens] - Gene

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Summary

Official Symbol: ALPK2provided by HGNC
Official Full Name: alpha-kinase 2provided by HGNC
Primary source: HGNC:20565
See related: Ensembl:ENSG00000198796; HPRD:11019; Vega:OTTHUMG00000132755
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HAK; FLJ34875; FLJ43253

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Genomic context

Location :: 18q21.31

Sequence :: Chromosome: 18; NC_000018.9 (56148479..56296189, complement)

See ALPK2 in Epigenomics, MapViewer

Chromosome 18 - NC_000018.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
kinase activity	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
protein phosphorylation	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: alpha-protein kinase 2

Names: alpha-protein kinase 2; heart alpha-kinase; heart alpha-protein kinase

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_052947.3 → NP_443179.3 alpha-protein kinase 2

Status: VALIDATED

Source sequence(s)

AC104971, AC105105

Consensus CDS

CCDS11966.2

UniProtKB/Swiss-Prot

Q86TB3

Related

ENSP00000354991, OTTHUMP00000163641, ENST00000361673, OTTHUMT00000256126

Conserved Domains (3) summary

cd00096
Location:29 – 96
Blast Score: 131

Ig; Immunoglobulin domain

cl03728
Location:1905 – 2125
Blast Score: 519

Alpha_kinase; Alpha-kinase family

cl11960
Location:1802 – 1874
Blast Score: 112

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000018.9 Reference GRCh37.p5 Primary Assembly

Range

56148479..56296189, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000150.1 Alternate HuRef

Range

52856619..53004353, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC104971.5 (68522..147138)	None
genomic	AC105105.10	None
genomic	CH471096.1	EAW63077.1
mRNA	AK092133.1	BAC03812.1
mRNA	AK092194.1	None
mRNA	AK125243.1	None
mRNA	AL832018.2	CAD89922.1
mRNA	AY044450.1	AAK95952.1
mRNA	BX647446.1	None
mRNA	BX647639.1	None
mRNA	BX647796.1	None
other-genetic	BC172418.1	AAI72418.1