Format

Send to:

Choose Destination

Adrb2 adrenergic receptor, beta 2 [ Mus musculus (house mouse) ]

Gene ID: 11555, updated on 29-May-2016
Official Symbol
Adrb2provided by MGI
Official Full Name
adrenergic receptor, beta 2provided by MGI
Primary source
MGI:MGI:87938
See related
Ensembl:ENSMUSG00000045730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Badm; Gpcr7; Adrb-2
Summary
This intronless gene belongs to the G-protein-coupled receptor superfamily, which includes transmembrane proteins that play a role in signal transduction across biological membranes resulting in a variety of physiological responses. The encoded protein is a beta-2 adrenergic receptor which is activated by catecholamine ligands such as adrenaline and epinephrine. The protein participates in the classical signaling pathway involving G protein, adenylyl cyclase, cAMP (3'-5'-cyclic adenosine monophosphate) and protein kinase A (PKA). In humans, this gene is implicated in susceptibility to nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Apr 2013]
Orthologs
Location:
18 E1; 18 35.1 cM
Exon count:
1
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 18 NC_000084.6 (62177713..62179981, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (62337470..62339613, complement)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41750 Neighboring gene predicted gene, 41749 Neighboring gene predicted gene, 36003 Neighboring gene predicted gene 9949 Neighboring gene predicted gene, 36124

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenoceptors, organism-specific biosystem (from REACTOME)
    Adrenoceptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Amine ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Amine ligand-binding receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Monoamine GPCRs, organism-specific biosystem (from WikiPathways)
    Monoamine GPCRs, organism-specific biosystem
    Monoamine GPCRs
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Non-odorant GPCRs, organism-specific biosystem (from WikiPathways)
    Non-odorant GPCRs, organism-specific biosystemListing of non-odorant Mouse GCPRs by coupling.
  • Regulation of lipolysis in adipocytes, organism-specific biosystem (from KEGG)
    Regulation of lipolysis in adipocytes, organism-specific biosystemLipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs as energy substrates, is a unique function of white adipose tissue. ...
  • Renin secretion, organism-specific biosystem (from KEGG)
    Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin secretion, conserved biosystem (from KEGG)
    Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Salivary secretion, organism-specific biosystem (from KEGG)
    Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Salivary secretion, conserved biosystem (from KEGG)
    Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
B2 bradykinin receptor binding ISO
Inferred from Sequence Orthology
more info
 
G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase binding IDA
Inferred from Direct Assay
more info
PubMed 
adrenergic receptor activity IEA
Inferred from Electronic Annotation
more info
 
beta2-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
beta2-adrenergic receptor activity ISO
Inferred from Sequence Orthology
more info
 
dopamine binding ISO
Inferred from Sequence Orthology
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
epinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
epinephrine binding ISO
Inferred from Sequence Orthology
more info
 
ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
norepinephrine binding ISO
Inferred from Sequence Orthology
more info
 
potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-activating G-protein coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
associative learning ISO
Inferred from Sequence Orthology
more info
 
bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
brown fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
desensitization of G-protein coupled receptor protein signaling pathway by arrestin ISO
Inferred from Sequence Orthology
more info
 
diaphragm contraction ISO
Inferred from Sequence Orthology
more info
 
diet induced thermogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
heat generation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
negative regulation of platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of urine volume ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ATPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of autophagosome maturation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipophagy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitophagy in response to mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
positive regulation of skeletal muscle tissue growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of the force of heart contraction by epinephrine ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of vasodilation ISO
Inferred from Sequence Orthology
more info
 
receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
regulation of smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of systemic arterial blood pressure by norepinephrine-epinephrine IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of vasodilation IEA
Inferred from Electronic Annotation
more info
 
response to cold IGI
Inferred from Genetic Interaction
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure IGI
Inferred from Genetic Interaction
more info
PubMed 
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
caveola ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
beta-2 adrenergic receptor
Names
beta 2-AR
beta-2 adrenoceptor
beta-2 adrenoreceptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007420.3NP_031446.2  beta-2 adrenergic receptor

    See identical proteins and their annotated locations for NP_031446.2

    Status: REVIEWED

    Source sequence(s)
    AC124430, BB844430, BC032883
    Consensus CDS
    CCDS29289.1
    UniProtKB/Swiss-Prot
    P18762
    Related
    ENSMUSP00000062256, ENSMUST00000053640
    Conserved Domains (2) summary
    pfam00001
    Location:57326
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:48340
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p3 C57BL/6J

    Range
    62177713..62179981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000040.1 Alternate Mm_Celera

    Range
    63462701..63464971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)