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Adra2a adrenergic receptor, alpha 2a [ Mus musculus (house mouse) ]

Gene ID: 11551, updated on 30-Jun-2015
Official Symbol
Adra2aprovided by MGI
Official Full Name
adrenergic receptor, alpha 2aprovided by MGI
Primary source
MGI:MGI:87934
See related
Ensembl:ENSMUSG00000033717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adra-2; Adra-2a; alpha2A; AW122659; alpha2-C10; alpha2A-AR; alpha(2A)AR
Orthologs
See Adra2a in Epigenomics, MapViewer
Location:
19 D2; 19 49.04 cM
Exon count:
1
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 19 NC_000085.6 (54045182..54048982)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (54119672..54123472)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene programmed cell death 4 Neighboring gene BBSome interacting protein 1 Neighboring gene soc-2 (suppressor of clear) homolog (C. elegans) Neighboring gene predicted gene, 41864 Neighboring gene predicted gene, 41865 Neighboring gene predicted gene, 41866

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
adrenergic receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
alpha-2C adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
alpha2-adrenergic receptor activity ISO
Inferred from Sequence Orthology
more info
 
alpha2-adrenergic receptor activity TAS
Traceable Author Statement
more info
PubMed 
epinephrine binding ISO
Inferred from Sequence Orthology
more info
 
heterotrimeric G-protein binding ISO
Inferred from Sequence Orthology
more info
 
norepinephrine binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
thioesterase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA replication ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity by adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-inhibiting adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
adenylate cyclase-inhibiting adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adrenergic receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular response to hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
female pregnancy ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin secretion involved in cellular response to glucose stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of norepinephrine secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of uterine smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
phospholipase C-activating adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epidermal growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vasodilation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
thermoception ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
alpha-2A adrenergic receptor
Names
alpha-2A adrenoceptor
alpha-2A adrenoreceptor
alpha-2AAR
alpha2A-adrenergic receptor
subtype alpha2-C10

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007417.4NP_031443.4  alpha-2A adrenergic receptor

    See identical proteins and their annotated locations for NP_031443.4

    Status: VALIDATED

    Source sequence(s)
    AC113491, AW122659, CJ171295
    Consensus CDS
    CCDS29905.1
    UniProtKB/TrEMBL
    Q3URE6
    Related
    ENSMUSP00000036203, ENSMUST00000036700
    Conserved Domains (2) summary
    pfam00001
    Location:71441
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10328
    Location:57185
    7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p3 C57BL/6J

    Range
    54045182..54048982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000041.1 Alternate Mm_Celera

    Range
    56240003..56243840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)