ZNF689 zinc finger protein 689 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: ZNF689provided by HGNC
Official Full Name: zinc finger protein 689provided by HGNC
Primary source: HGNC:25173
See related: HPRD:14009
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TIPUH1

Genomic context

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Location :: 16p11.2

Sequence :: Chromosome: 16; NC_000016.9 (30614686..30621682, complement)

See ZNF689 in Epigenomics, MapViewer

Chromosome 16 - NC_000016.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results indicate that ZNF689 blocks pro-apoptotic signaling by suppressing the Bak/Bax/Bid pathway, resulting in the progression of liver cancer and resistance to 5-FU. ZNF689 may be a promising chemotherapeutic target against liver cancer.
Title: ZNF689 suppresses apoptosis of hepatocellular carcinoma cells through the down-regulation of Bcl-2 family members.
overexpressed TIPUH1 may play a role in hepatocarcinogenesis by regulating transcription and/or RNA processing of growth control genes
Title: TIPUH1 encodes a novel KRAB zinc-finger protein highly expressed in human hepatocellular carcinomas.
TIPUH1 conferred anchorage independent growth and its knockdown in HCCs resulted in their growth inhibition. Interacts with TIF1beta, hnRNPU, hnRNPF, Nucleolin. May play a role in hepatocarcinogenesis by regulating transcription and/or RNA processing.
Title: TIPUH1 encodes a novel KRAB zinc-finger protein highly expressed in human hepatocellular carcinomas.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
Q96CS4	P52597	HNRNPF	HPRD	PubMed
Q96CS4	Q00839	HNRNPU	HPRD	PubMed
Q96CS4	P19338	NCL	HPRD	PubMed
Q96CS4	Q13263	TRIM28	HPRD	PubMed
BioGRID:125436	BioGRID:117030	CBX5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:125436	BioGRID:109426	HNRNPF	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:125436	BioGRID:109433	HNRNPU	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:125436	BioGRID:110771	NCL	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:125436	BioGRID:121244	SMARCAD1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:125436	BioGRID:115457	TRIM28	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western

Pathways from BioSystems

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Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

General gene information

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Markers

SHGC-61056 (e-PCR)
- UniSTS:89688

D16S2667 (e-PCR)
- UniSTS:152415

RH75465 (e-PCR)
- UniSTS:92355

Homology

Homologs of the ZNF689 gene: The ZNF689 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 689

Names: zinc finger protein 689; transcription-involved protein upregulated in HCC 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138447.2 → NP_612456.1 zinc finger protein 689

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.

Source sequence(s)

AL834299, BC014000, DA485303

Consensus CDS

CCDS10686.1

UniProtKB/Swiss-Prot

Q96CS4

Conserved Domains (4) summary

COG5048
Location:159 – 466
Blast Score: 110

COG5048; FOG: Zn-finger [General function prediction only]

cd07765
Location:29 – 68
Blast Score: 181

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box.

smart00349
Location:29 – 88
Blast Score: 263

KRAB; krueppel associated box

pfam13465
Location:219 – 244
Blast Score: 87

zf-H2C2_2; Zinc-finger double domain

RNA

NR_073480.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.

Source sequence(s)

AK310459, AL834299, DA485303
NR_073481.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.

Source sequence(s)

AL834299, BC014000, CN406120, DA010230
NR_073482.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.

Source sequence(s)

AL834299, BC014000, DB456506

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000016.9 Reference GRCh37.p10 Primary Assembly

Range

30614686..30621682, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000148.1 Alternate HuRef

Range

28178270..28185265, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018927.1 Alternate CHM1_1.0

Range

31615487..31622481, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01042043.1 (5643..12638)	None
genomic	AC093249.4 (96759..103755)	None
genomic	AMYH01007497.1 (744667..751661)	None
genomic	CH471192.1	EAW52228.1
genomic	CQ756574.1	CAF32597.1
genomic	CQ783987.1	CAF86958.1
mRNA	AB065282.1	BAB83744.1
mRNA	AF086510.1	None
mRNA	AK074896.1	BAC11275.1
mRNA	AK310459.1	None
mRNA	AL834299.1	CAH56363.1
mRNA	BC014000.2	AAH14000.1
mRNA	CN406120.1	None
mRNA	DA010230.1	None
mRNA	DA485303.1	None
mRNA	DB456506.1	None