TBCB tubulin folding cofactor B [Homo sapiens] - Gene

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Summary

Official Symbol: TBCBprovided by HGNC
Official Full Name: tubulin folding cofactor Bprovided by HGNC
Primary source: HGNC:1989
See related: Ensembl:ENSG00000105254; HPRD:03196; MIM:601303; Vega:OTTHUMG00000048143
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CG22; CKAP1; CKAPI; MGC14625

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Genomic context

Location :: 19q13.11-q13.12

Sequence :: Chromosome: 19; NC_000019.9 (36605888..36616849)

See TBCB in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Study demonstrates that, unlike its counterpart TBCE, TBCB only moderately destabilizes microtubules; neither TBCB abundance nor microtubule organization or densities are altered in giant axonal neuropathy mutant fibroblasts.
Title: Gigaxonin controls vimentin organization through a tubulin chaperone-independent pathway.
TBCB functions as a microtubule density regulator in microglia during activation, and provide an insight into understanding of mechanisms controlling microtubule reorganization during microglial transition between phenotypes.
Title: Tubulin cofactor B regulates microtubule densities during microglia transition to the reactive states.
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Title: Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
These findings identified TCoB as the third cytoskeleton protein to be nitrated and suggest a previously undescribed mechanism, whereby growth factor signaling may coordinately integrate nitric oxide signaling in the regulation of microtubule dynamics.
Title: Dynamic interplay between nitration and phosphorylation of tubulin cofactor B in the control of microtubule dynamics.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q99426	Q9H2C0	GAN	HPRD	PubMed
Q99426	P68366	TUBA4A	HPRD	PubMed
Q99426	Q93009	USP7	HPRD	PubMed
BioGRID:107575	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
'de novo' posttranslational protein folding	TAS Traceable Author Statement more info
cell differentiation	IEA Inferred from Electronic Annotation more info
cellular protein metabolic process	TAS Traceable Author Statement more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
nervous system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
microtubule	IEA Inferred from Electronic Annotation more info
microtubule cytoskeleton	TAS Traceable Author Statement more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: tubulin-folding cofactor B

Names: tubulin-folding cofactor B; tubulin-specific chaperone B; cytoskeleton associated protein 1; cytoskeleton-associated protein 1; cytoskeleton-associated protein CKAPI

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001281.2 → NP_001272.2 tubulin-folding cofactor B

Status: VALIDATED

Source sequence(s)

AI126083, AL555345, BC005969, D49738

Consensus CDS

CCDS12488.1

UniProtKB/Swiss-Prot

Q99426

Related

ENSP00000221855, OTTHUMP00000081860, ENST00000221855, OTTHUMT00000156291

Conserved Domains (2) summary

cd01789
Location:10 – 93
Blast Score: 372

Alp11_N; Ubiquitin-like domain of Alp11 tubulin-folding cofactor B

cl08315
Location:161 – 226
Blast Score: 273

CAP_GLY; CAP-Gly domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p5 Primary Assembly

Range

36605888..36616849

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

33111374..33122336

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AD001527.1	AAB51182.1
mRNA	AF013488.1	AAB67716.1
mRNA	AI126083.1	None
mRNA	AL555345.3	None
mRNA	BC005969.1	AAH05969.1
mRNA	BC052812.1	AAH52812.1
mRNA	BT007424.1	AAP36092.1
mRNA	CR541971.1	CAG46769.1
mRNA	D49738.1	BAA08572.1
other-genetic	DQ892900.2	ABM83826.1
other-genetic	DQ896150.2	ABM87149.1