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Parp1 poly (ADP-ribose) polymerase family, member 1 [ Mus musculus (house mouse) ]

Gene ID: 11545, updated on 29-May-2016
Official Symbol
Parp1provided by MGI
Official Full Name
poly (ADP-ribose) polymerase family, member 1provided by MGI
Primary source
MGI:MGI:1340806
See related
Ensembl:ENSMUSG00000026496 Vega:OTTMUSG00000050450
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PARP; PPOL; ARTD1; Adprp; Adprt1; C80510; parp-1; sPARP-1; AI893648; 5830444G22Rik
Orthologs
Location:
1 84.44 cM; 1 H5
Exon count:
23
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (180568975..180601254)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (182499106..182531385)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6330403A02 gene Neighboring gene predicted gene, 31986 Neighboring gene microRNA 6904 Neighboring gene lin-9 homolog (C. elegans) Neighboring gene Mix1 homeobox-like 1 (Xenopus laevis)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA ligase (ATP) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
NAD binding ISO
Inferred from Sequence Orthology
more info
 
NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD+ ADP-ribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
NAD+ ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
SMAD binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein ADP-ribosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring glycosyl groups IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA damage response, detection of DNA damage ISO
Inferred from Sequence Orthology
more info
 
DNA ligation involved in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
 
DNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA repair TAS
Traceable Author Statement
more info
PubMed 
base-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to beta-amyloid ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to superoxide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
double-strand break repair IGI
Inferred from Genetic Interaction
more info
PubMed 
double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
lagging strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrial DNA metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
mitochondrial DNA repair ISO
Inferred from Sequence Orthology
more info
PubMed 
mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion organization ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of telomere maintenance via telomere lengthening IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of SMAD protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of myofibroblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
protein ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
protein autoprocessing ISO
Inferred from Sequence Orthology
more info
 
protein modification process ISO
Inferred from Sequence Orthology
more info
PubMed 
protein poly-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein poly-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
regulation of DNA methylation ISO
Inferred from Sequence Orthology
more info
 
regulation of SMAD protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of cellular protein localization ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of growth rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of single strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
signal transduction involved in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
nuclear chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
poly [ADP-ribose] polymerase 1
Names
ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1
ADP-ribosyltransferase diphtheria toxin-like 1
ADPRT 1
NAD(+) ADP-ribosyltransferase 1
msPARP
poly(ADP-ribose) polymerase
poly[ADP-ribose] synthase 1
poly[ADP-ribose] synthetase 1
NP_031441.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007415.2NP_031441.2  poly [ADP-ribose] polymerase 1

    See identical proteins and their annotated locations for NP_031441.2

    Status: PROVISIONAL

    Source sequence(s)
    BC012041
    Consensus CDS
    CCDS15569.1
    UniProtKB/TrEMBL
    Q921K2
    Related
    ENSMUSP00000027777, OTTMUSP00000068942, ENSMUST00000027777, OTTMUST00000128005
    Conserved Domains (6) summary
    cd08001
    Location:543645
    WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
    PLN03123
    Location:91010
    PLN03123; poly [ADP-ribose] polymerase; Provisional
    cd00027
    Location:393462
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cd01437
    Location:6621006
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    pfam00645
    Location:1290
    zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
    pfam08063
    Location:280333
    PADR1; PADR1 (NUC008) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    180568975..180601254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    187634811..187667071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)