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GBP4 guanylate binding protein 4 [ Homo sapiens (human) ]

Gene ID: 115361, updated on 26-May-2016
Official Symbol
GBP4provided by HGNC
Official Full Name
guanylate binding protein 4provided by HGNC
Primary source
See related
Ensembl:ENSG00000162654 HPRD:13570; MIM:612466; Vega:OTTHUMG00000010663
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008]
Exon count:
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (89181148..89198950, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (89646831..89664633, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene guanylate binding protein 2 Neighboring gene uncharacterized LOC105378842 Neighboring gene guanylate binding protein 7 Neighboring gene uncharacterized LOC105378843 Neighboring gene guanylate binding protein family member 6 pseudogene Neighboring gene guanylate binding protein 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of guanylate binding protein 4 (GBP4) expression as compared to untreated control PubMed
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of guanylate binding protein 4 (GBP4) in primary human brain microvascular endothelial cells PubMed
Vif vif HIV-1 Vif upregulates the expression of guanylate binding protein 4 (GBP4) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
    Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...


Potential readthrough

Included gene: GBP5


Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
GTPase activity IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
nucleus IEA
Inferred from Electronic Annotation
more info
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
Preferred Names
guanylate-binding protein 4
GTP-binding protein 4
guanine nucleotide-binding protein 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052941.4NP_443173.2  guanylate-binding protein 4

    See identical proteins and their annotated locations for NP_443173.2

    Status: VALIDATED

    Source sequence(s)
    AC104459, AF288814, BC008421, BC070055, CA309701
    Consensus CDS
    ENSP00000359490, OTTHUMP00000012394, ENST00000355754, OTTHUMT00000029409
    Conserved Domains (2) summary
    GBP_C; Guanylate-binding protein, C-terminal domain
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly


  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    89181148..89198950 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1


  1. NC_018912.2 Alternate CHM1_1.1

    89761894..89779694 complement
    GenBank, FASTA, Sequence Viewer (Graphics)