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OMA1 OMA1 zinc metallopeptidase [ Homo sapiens (human) ]

Gene ID: 115209, updated on 8-May-2016
Official Symbol
OMA1provided by HGNC
Official Full Name
OMA1 zinc metallopeptidaseprovided by HGNC
Primary source
HGNC:HGNC:29661
See related
Ensembl:ENSG00000162600 HPRD:14879; Vega:OTTHUMG00000010068
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAB1; MPRP-1; YKR087C; ZMPOMA1; peptidase; 2010001O09Rik
Orthologs
Location:
1p32.2-p32.1
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (58480719..58546799, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (58881052..59012469, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene DAB1, reelin adaptor protein Neighboring gene ribosomal protein S26 pseudogene 15 Neighboring gene VKORC1 pseudogene 2 Neighboring gene tumor-associated calcium signal transducer 2 Neighboring gene adenylate kinase 2 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: DAB1

Homology

Clone Names

  • FLJ33782

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
cristae formation IEA
Inferred from Electronic Annotation
more info
 
diet induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
misfolded or incompletely synthesized protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to stress IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
metalloendopeptidase OMA1, mitochondrial
Names
OMA1 homolog, zinc metallopeptidase
OMA1 zinc metallopeptidase homolog
metalloprotease related protein 1
metalloprotease-related protein 1
overlapping activity with M-AAA protease
overlapping with the m-AAA protease 1 homolog
zinc metallopeptidase OMA1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145243.4NP_660286.1  metalloendopeptidase OMA1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_660286.1

    Status: VALIDATED

    Source sequence(s)
    AB048348, BC012915, BU191827
    Consensus CDS
    CCDS608.1
    UniProtKB/Swiss-Prot
    Q96E52
    Related
    ENSP00000360270, OTTHUMP00000011756, ENST00000371226, OTTHUMT00000027819
    Conserved Domains (1) summary
    cl12018
    Location:235447
    Peptidase_M48; Peptidase family M48

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    58480719..58546799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    59060902..59127834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)