CKB creatine kinase, brain [Homo sapiens] - Gene

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Summary

Official Symbol: CKBprovided by HGNC
Official Full Name: creatine kinase, brainprovided by HGNC
Primary source: HGNC:1991
See related: Ensembl:ENSG00000166165; HPRD:00423; MIM:123280; Vega:OTTHUMG00000171786
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: B-CK; CKBB
Summary: The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 14q32

Sequence :: Chromosome: 14; NC_000014.8 (103985996..103989170, complement)

See CKB in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cigarette smoke induced carbonylation and subsequent degradation of creatine kinase B are involved in the regulation of senescence in bronchial epithelial cells.
Title: Involvement of creatine kinase B in cigarette smoke-induced bronchial epithelial cell senescence.
The results suggested that the intra- and inter-subunit domain interactions modified the behavior of kinetic refolding.
Title: Dissimilarity in the folding of human cytosolic creatine kinase isoenzymes.
Data demonstrate that the downregulation of CKB may play an important role in colon cancer progression by promoting EMT.
Title: Creatine kinase brain overexpression protects colorectal cells from various metabolic and non-metabolic stresses.
CKB was up-regulated in women older than 38 years, and its expression in cumulus cells was associated with embryo quality
Title: Association of creatin kinase B and peroxiredoxin 2 expression with age and embryo quality in cumulus cells.
These observations suggested that the ability to generate the oxidized form could protect BBCK against the intracellular oxidative stress.
Title: Generation of the oxidized form protects human brain type creatine kinase against cystine-induced inactivation.
Report the effects of prior calcium channel blocker therapy on creatine kinase-MB (myocardial form) levels after percutaneous coronary interventions.
Title: The effects of prior calcium channel blocker therapy on creatine kinase-MB levels after percutaneous coronary interventions.
A single troponin I value at 3 days from symptom onset is a better predictor of infarct size compared to peak values and CK-MB.
Title: Predictive value of cardiac troponin-I compared to creatine kinase-myocardial band for the assessment of infarct size as measured by cardiac magnetic resonance.
Phosphocreatine metabolism in the normal appearing white matter in multiple sclerosis is impaired due to decreased CK-B levels.
Title: Reduced creatine kinase B activity in multiple sclerosis normal appearing white matter.
The correlation of CK-BB as a disease biomarker in both CNS and peripheral tissues from Huntington's disease mice and patients may provide a powerful means to assess disease progression and prognosis.
Title: Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease.
This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia.
Title: Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation.

Submit: New GeneRIF Correction See all (22)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P12277	Q96DX5	ASB9	HPRD	PubMed
P12277	P06732	CKM	HPRD	PubMed
P12277	Q8N6R1	SERP2	HPRD	PubMed
BioGRID:107572	BioGRID:126615	ASB9	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Two-hybrid
BioGRID:107572	BioGRID:115331	HDAC5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107572	BioGRID:109824	ILK	BioGRID	PubMed	Two-hybrid
BioGRID:107572	BioGRID:204968	Mapk13	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107572	BioGRID:111493	PPP1CA	BioGRID	PubMed	Two-hybrid
BioGRID:107572	BioGRID:111657	PSMA3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107572	BioGRID:132508	SERP2	BioGRID	PubMed	Two-hybrid
BioGRID:107572	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107572	BioGRID:115717	TAB1	BioGRID	PubMed	Two-hybrid
BioGRID:107572	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:107572	BioGRID:115283	USP15	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107572	BioGRID:115503	USPL1	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
creatine kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
brain development	IEA Inferred from Electronic Annotation more info
cellular chloride ion homeostasis	IEA Inferred from Electronic Annotation more info
cellular nitrogen compound metabolic process	TAS Traceable Author Statement more info
creatine metabolic process	TAS Traceable Author Statement more info
small molecule metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: creatine kinase B-type

Names: creatine kinase B-type; creatine kinase-B; creatine kinase B chain

NP_001814.2

EC 2.7.3.2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001823.4 → NP_001814.2 creatine kinase B-type

Status: REVIEWED

Source sequence(s)

AK312282, BM684665, BP213119

Consensus CDS

CCDS9981.1

UniProtKB/Swiss-Prot

P12277

Related

ENSP00000299198, OTTHUMP00000246847, ENST00000348956, OTTHUMT00000415111

Conserved Domains (1) summary

cd00716
Location:16 – 373
Blast Score: 1787

creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes.

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p5 Primary Assembly

Range

103985996..103989170, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

84164415..84167531, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL133367.4 (13457..16631)	None
genomic	CH471061.1	EAW81820.1
		EAW81821.1
		EAW81822.1
genomic	DQ333313.1	ABC67465.1
genomic	M21236.1 (400..482)	None
genomic	M21243.1	AAC31758.1
genomic	M22354.1 (178..254)	None
genomic	M22356.1	AAA52024.1
genomic	X15334.1	CAA33389.1
mRNA	AK290101.1	BAF82790.1
mRNA	AK298198.1	BAG60468.1
mRNA	AK312282.1	BAG35211.1
mRNA	BC001190.1	AAH01190.1
mRNA	BC004914.2	AAH04914.1
mRNA	BC008323.1	AAH08323.1
mRNA	BC010002.2	AAH10002.1
mRNA	BC019259.1	AAH19259.1
mRNA	BC019281.1	AAH19281.1
mRNA	BG720434.1	None
mRNA	BM684665.1	None
mRNA	BP213119.1	None
mRNA	CR542268.1	CAG47064.1
mRNA	L47647.1	AAA76852.1
mRNA	M16364.1	AAA76850.1
mRNA	M16451.1	AAA76851.1
other-genetic	JF432538.1	ADZ15755.1