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Adcy6 adenylate cyclase 6 [ Mus musculus (house mouse) ]

Gene ID: 11512, updated on 8-May-2016
Official Symbol
Adcy6provided by MGI
Official Full Name
adenylate cyclase 6provided by MGI
Primary source
MGI:MGI:87917
See related
Ensembl:ENSMUSG00000022994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AC6; mKIAA0422
Orthologs
Location:
15; 15 F
Exon count:
24
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 15 NC_000081.6 (98589978..98610140, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (98420409..98438064, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene cyclin T1 Neighboring gene RIKEN cDNA 9330020H09 gene Neighboring gene RIKEN cDNA 4930415O20 gene Neighboring gene calcium channel, voltage-dependent, beta 3 subunit Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
SNARE binding ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
calcium- and calmodulin-responsive adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
calcium- and calmodulin-responsive adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adenylate cyclase-activating G-protein coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
cAMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular response to catecholamine stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to forskolin IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
 
cellular response to prostaglandin E stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to vasopressin IMP
Inferred from Mutant Phenotype
more info
PubMed 
cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
maintenance of protein location in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of urine volume IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of vasodilation ISO
Inferred from Sequence Orthology
more info
 
renal water homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
cilium IEA
Inferred from Electronic Annotation
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intrinsic component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
microvillus membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with sarcolemma ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
adenylate cyclase type 6
Names
ATP pyrophosphate-lyase 6
adenylate cyclase type VI
adenylyl cyclase 6
ca(2+)-inhibitable adenylyl cyclase
NP_031431.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007405.2NP_031431.2  adenylate cyclase type 6

    See identical proteins and their annotated locations for NP_031431.2

    Status: VALIDATED

    Source sequence(s)
    AK147516, BU611374, M93422
    Consensus CDS
    CCDS27799.1
    UniProtKB/Swiss-Prot
    Q01341
    UniProtKB/TrEMBL
    F8VQ52
    Related
    ENSMUSP00000093939, ENSMUST00000096224
    Conserved Domains (3) summary
    cd07302
    Location:9781162
    CHD; cyclase homology domain
    smart00044
    Location:332529
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam06327
    Location:578669
    DUF1053; Domain of Unknown Function (DUF1053)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p3 C57BL/6J

    Range
    98589978..98610140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520307.2XP_006520370.1  

    Conserved Domains (3) summary
    cd07302
    Location:389564
    CHD; cyclase homology domain
    smart00044
    Location:346541
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam06327
    Location:590681
    DUF1053; Domain of Unknown Function (DUF1053)
  2. XM_006520306.2XP_006520369.2  

    See identical proteins and their annotated locations for XP_006520369.2

    Conserved Domains (3) summary
    cd07302
    Location:375550
    CHD; cyclase homology domain
    smart00044
    Location:332527
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam06327
    Location:576667
    DUF1053; Domain of Unknown Function (DUF1053)
  3. XM_006520315.1XP_006520378.1  

    See identical proteins and their annotated locations for XP_006520378.1

    Conserved Domains (3) summary
    cd07302
    Location:375550
    CHD; cyclase homology domain
    smart00044
    Location:332527
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam06327
    Location:576667
    DUF1053; Domain of Unknown Function (DUF1053)
  4. XM_006520314.2XP_006520377.1  

    See identical proteins and their annotated locations for XP_006520377.1

    Conserved Domains (3) summary
    cd07302
    Location:375550
    CHD; cyclase homology domain
    smart00044
    Location:332527
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam06327
    Location:576667
    DUF1053; Domain of Unknown Function (DUF1053)
  5. XM_006520303.2XP_006520366.2  

    Conserved Domains (3) summary
    cd07302
    Location:412587
    CHD; cyclase homology domain
    smart00044
    Location:369564
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam06327
    Location:613704
    DUF1053; Domain of Unknown Function (DUF1053)

RNA

  1. XR_383971.2 RNA Sequence

  2. XR_875221.1 RNA Sequence

  3. XR_383972.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000037.1 Alternate Mm_Celera

    Range
    100737585..100755761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)