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Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 [ Mus musculus (house mouse) ]

Gene ID: 11504, updated on 28-May-2016
Official Symbol
Adamts1provided by MGI
Official Full Name
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1provided by MGI
Primary source
MGI:MGI:109249
See related
Ensembl:ENSMUSG00000022893 Vega:OTTMUSG00000019935
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C3-C5; METH1; ADAMTS; METH-1; ADAM-TS1; ADAMTS-1
Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family and preproprotein that is proteolytically processed to generate a mature protein product. This secreted protein product plays an important role in ovulation, likely through its cleavage of the extracellular matrix component versican. The encoded protein may enhance tumorigenesis in a mouse model of breast cancer. Homozygous knockout mice for this gene exhibit enhanced perinatal lethality, impaired growth and adipose tissue development, and impaired ovulation in females. [provided by RefSeq, Oct 2015]
Orthologs
Location:
16 48.2 cM; 16 C3-C5
Exon count:
9
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 16 NC_000082.6 (85793827..85803115, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (85794072..85803360, complement)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 6 pseudogene Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene RIKEN cDNA 4930556C24 gene Neighboring gene a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
metalloendopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
heart trabecula formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
ovulation from ovarian follicle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
proteinaceous extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 1
Names
ADAM-TS 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009621.5NP_033751.3  A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein

    See identical proteins and their annotated locations for NP_033751.3

    Status: REVIEWED

    Source sequence(s)
    AC126936, AK161409, AK163622, BP764139, CF738767
    Consensus CDS
    CCDS28287.1
    UniProtKB/Swiss-Prot
    P97857
    UniProtKB/TrEMBL
    Q3TQF7, Q3TTE6
    Related
    ENSMUSP00000023610, OTTMUSP00000021492, ENSMUST00000023610, OTTMUST00000047513
    Conserved Domains (6) summary
    smart00209
    Location:563615
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:259464
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:259468
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:62174
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:726843
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:469549
    ADAM_CR; ADAM cysteine-rich

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p3 C57BL/6J

    Range
    85793827..85803115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000038.1 Alternate Mm_Celera

    Range
    86012366..86021639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)